@article { author = {El-Deeb, Mona Mohamed K and El-Sheredy, Heba Gaber and Mohammed, Ayman Farouk}, title = {The Possible Role of Interleukin (IL)-18 and Nitrous Oxide and Their Relation to Oxidative Stress in the Development and Progression of Breast Cancer}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {20}, number = {9}, pages = {2659-2665}, year = {2019}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2019.20.9.2659}, abstract = {Background: Cancer breast is the most common malignant tumor in females globally. Mechanisms linkinginflammatory cytokines and tumour growth and progression have not been established. Interleukin (IL)-18 has amodifying role in the immune defense against tumor cells. It induces production of IFN-γ. It also increases the immunecells cytotoxic activity and enhances the production of other proinflammatory cytokine. Nitric oxide (NO) has bothpromoting and inhibiting effects on tumorigenesis. Oxidative stress is a phenomenon that leads to oxidative damageof biomolecules, mutagenesis and carcinogenesis. Objective: The purpose of this research is to identify the potentialrole of IL18 and NO and their relation to oxidative stress in the development of cancer breast. Patients and Methods:This study included 120 women split into two groups ; control group and patient groups that divided into: group B (30patients with benign breast tumors), group N (30newly diagnosed cancer breast patients) ; and group M (30 metastaticcancer breast patients). Results: Serum total anti-oxidant capacity was significant high in both cancer breast groups.Total oxidative capacity was significantly higher level in metastatic group. NO levels were significantly higher valuesin the three cancer breast patients groups compared to control group.IL18 was significantly high in the metastaticgroup. Conclusions: Serum IL-18 and NO activity can be used as a marker for evaluating disease activity in patientswith cancer breast.}, keywords = {Interleukin -18,nitric oxide,breast cancer,oxidative stress}, url = {https://journal.waocp.org/article_88747.html}, eprint = {https://journal.waocp.org/article_88747_ab8efe25d641cf85550f8082b528f66c.pdf} }