@article { author = {Al-Shawi, Ali A A and Hameed, Mustafa Fadhil and Ali, Nashwan Hussein and Hussein, Kawkab Ali}, title = {Investigations of Phytoconstituents, Antioxidant and Anti-Liver Cancer Activities of Saueda monoica Forssk Extracted by Microwave-Assisted Extraction}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {21}, number = {8}, pages = {2349-2355}, year = {2020}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2020.21.8.2349}, abstract = {Background: Wild edible plants are good sources for bioactive compounds, vitamins, and minerals with various applications. They can play a role in supporting the immune system and are highly beneficial as resources. Suaeda monoica Forssk is a wild edible plant that grows in Iraq and it’s biological activities have not yet reported. Methods: Saueda monoica Forssk bioactive compounds were extracted by a microwave-assisted extraction method using ethanol as a solvent, and its chemical composition was analyzed by GC-MS. The biological activities were evaluated via antioxidant, anti-liver-cancer, antibacterial, and toxicity tests in vitro. Results: The results of GC-MS analysis showed that there were about 20 bioactive compounds. The most abundant compound was N,N-Dimethylglycine methyl ester, followed by 9,12,15-Octadecatrienoic acid, n-Hexadecanoic acid, and N,N-Dimethylglycine. The antioxidant activity of the ethanol extract of the plant showed a significant IC50. The extract of S. monoica against liver cancer cells (HCAM) showed significant toxicity. Flow cytometric analysis showed a significant induced apoptosis and cell cycle arrested at G1 phase. Conclusions: The results indicated the significance of the components of Iraqi S. monoica Forssk by MAE method as a potential food supplement in nutrition systems to prevent liver cancer and enhance the liver’s defense against diseases.  }, keywords = {Apoptosis,Cell cycle,Liver cancer,Natural antioxidants,Saueda monoica Forssk}, url = {https://journal.waocp.org/article_89227.html}, eprint = {https://journal.waocp.org/article_89227_2fa07e691e16a56cc302dbf34c52c7f1.pdf} }