@article { author = {Wardana, Tirta and Gunawan, Lisa and Herawati, Cita and Oktriani, Risky and Anwar, Sumadi and Astuti, Indwiani and Aryandono, Teguh and Mubarika, Sofia}, title = {Circulation EBV Mir-Bart-7 Relating to Clinical Manifestation in Nasopharyngeal Carcinoma}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {21}, number = {9}, pages = {2777-2782}, year = {2020}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2020.21.9.2777}, abstract = {Objective: Nasopharyngeal Carcinoma (NPC) is an endemic head and neck malignancy in Asia Pacific regions that is associated with chronic infection by Epstein-Barr virus (EBV). EBV miR-BART-7 is a microRNA (miRNA) encoded by EBV that regulates malignant behavior of NPC. However, the role and function of miR-BART7 are not clear, particularly the relation of circulating levels and patient’s clinical presentation. Methods: Circulating miR-BART-7 levels were measured by using qRT-PCR and were correlated with clinical and pathological data. Result: Of 52 NPC patients included in this study, 85% were diagnosed in the late stages (Stage III-IV). 73% of tumors were non-keratinizing undifferentiated NPC, 92% of tumors were WHO class III histology and all cases were EBV-IgA positive. Over-expression of miR-BART7-3p was correlated with positive regional lymph nodes in newly diagnosed (4.61 fold changes, p <0.05). Conclusion: Over-expression of circulating EBV miR-BART7 correlated with positive regional lymph nodes reflecting the diagnostic and prognostic values of circulating miR-BART7 for patients with NPC.}, keywords = {EBV,MicroRNA,BART7,Nasopharyngeal carcinoma,circulation}, url = {https://journal.waocp.org/article_89283.html}, eprint = {https://journal.waocp.org/article_89283_923ca9a14fe1a2c6b3684f528267b71f.pdf} }