@article { author = {Elnaggar, Ghada and El-Hifnawi, Niveen and Ismail, Abeer and Yahia, Maha and Elshimy, Reham}, title = {Micro RNA-148a Targets Bcl-2 in Patients with Non-Small Cell Lung Cancer}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {22}, number = {6}, pages = {1949-1955}, year = {2021}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2021.22.6.1949}, abstract = {Objective: Lung cancer is one of the most prevalent cancers and the leading cause of cancer-related deaths worldwide. MicroRNAs regulate more than 60% of human genes, including tumor suppressor genes and oncogenes. Accordingly, they can affect cancer risk. This study aimed to evaluate the role of serum miR-148a as a non-invasive biomarker in non-small cell lung cancer (NSCLC) patients and to assess the correlation between miR-148a and Bcl-2, as one of its target proteins. Materials and Methods: A total of 50 newly diagnosed NSCLC cases and 30 apparently healthy controls were recruited in this study. MiR-148a level was measured by TaqMan- Real time RT-PCR assay and Bcl-2 level was measured by ELISA. Results: Significant lower expression of serum miR-148a and higher serum Bcl-2 levels were observed in NSCLC patients as compared to the control group (p  }, keywords = {MiR-148a,Bcl-2,NSCLC}, url = {https://journal.waocp.org/article_89649.html}, eprint = {https://journal.waocp.org/article_89649_d2a37607cf24fc094340cb2617b2f1e6.pdf} }