@article { author = {Guneydas, Goksu and Topcul, Mehmet R}, title = {Antiproliferative Effects of Curcumin Different Types of Breast Cancer}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {23}, number = {3}, pages = {911-917}, year = {2022}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2022.23.3.911}, abstract = {Objective: Breast cancer is one of the most frequently diagnosed malignancy among women. Turmeric is isolated from Curcuma longa. Curcumin is main curcuminoid of the turmeric which is a member of Zingiberaceae. In this current study antiproliferative effects of curcumin were investigated in luminal A breast cancer cell line MCF-7 and triple negative breast cancer cell line MDA-MB-231. Methods: For this purpose cell viability, cell index values by xCELLigence Real-Time Cell Analysis DP instrument, mitotic index and apoptotic index analysis were used. Results: Cell viability and cell index values showed that 75 µM concentration of curcumin was IC50 concentration. When IC50 concentration was applied to both cell lines, a significant decrease was observed in the mitotic index values, while a significant increase was observed in the apoptotic index values (p<0.05). Conclusion: Curcumin, which has antiproliferative effects on breast cancer cells, is thought to be effective in cancer treatment.}, keywords = {curcumin,breast cancer,Cell kinetics,xCelligence}, url = {https://journal.waocp.org/article_90024.html}, eprint = {https://journal.waocp.org/article_90024_34a6cc208b3344583fbb67b180560f18.pdf} }