@article { author = {Hoang, Yen and Nguyen, Yen and Nguyen, Hai and Le, Anh and Bui, Huong and Vu, Nhung and Nguyen, Ha}, title = {Single Nucleotide Polymorphisms of ADH1B, ADH1C and ALDH2 Genes in 235 People Living in Thai Nguyen Province of Vietnam}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {23}, number = {12}, pages = {4243-4251}, year = {2022}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2022.23.12.4243}, abstract = {Objective: ADH1B, ADH1C and ALDH2 genes are mainly responsible for alcohol metabolism in the body. Severalsingle nucleotide polymorphisms (SNPs) of these genes have been reported to be associated with alcohol dependenceand are considered risk factors for various human diseases. This study aims to identify the prevalence of three SNPs ofADH1B (rs1229984), ADH1C (rs698) and ALDH2 (rs671) in 235 unrelated individuals living in Thai Nguyen province,the northeast region of Vietnam. Methods: The target genotypes were identified by using PCR direct sequencing, andtheir frequencies were compared to previous reports. Result: Our data showed that allele frequencies of ADH1B*2(rs1229984), ADH1C*2 C (rs698) and ALDH2*2 (rs671) were 68.8%, 8.3% and 20.4%, respectively. The ADH1B*2and ADH1C*2 frequencies were similar to those of the Kinh ethnic individuals living in the south region of Vietnam,while the ALDH2*2 frequency was higher. Compared to data from other countries, ADH1B*2 frequency is similar tothe Philippines (60.5%) and Mongolia (62.9%) but significantly different from the other populations. The ADH1C*2frequency is not so different compared to Japanese (5.7%) and Chinese (7.1%) but is quite different in other populations.ALDH2*2 frequency was lower than Japanese (29.3%), Indonesian (30%) and higher than other countries. Regardingthe risk of alcoholism, the percentage of Vietnamese people in this study with genotypes related to alcohol dependenceis 8.1%. In contrast, the carrier has genotypes protecting against alcoholism with high frequency, 91.9%. Among them,the individuals can cause high acetaldehyde accumulation accounting for 33.2%. Conclusion: This study helps tounderstand the genetic polymorphisms of alcohol metabolism genes in the community living in Thai Nguyen province,northeast of Vietnam, and provides valuable scientific data relating to alcohol consumption behavior as well as publichealth protection.}, keywords = {ADH1B,ADH1C,ALDH2,genetic polymorphisms,Thai Nguyen-Vietnamese}, url = {https://journal.waocp.org/article_90414.html}, eprint = {https://journal.waocp.org/article_90414_806e196b3fd0120fe819fe3627b2fc1c.pdf} }