@article { author = {Molaei, Vahid and Fattahi, Mohammad Reza and Haghshenas, Mohammad Reza and Hosseini, Seyed Younes and Malekhosseini, Seyed Ali and Sarvari, Jamal}, title = {Polymorphism Analysis of Interleukin-18 and Interleukin-37 Genes in Hepatitis B Infections with Different Outcomes: A Preliminary Report from an Iranian Population}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {24}, number = {2}, pages = {411-416}, year = {2023}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2023.24.2.411}, abstract = {Objective: Given the vital role of cytokines in influencing the outcomes of hepatitis B virus (HBV) infections, this study aimed to investigate the association between polymorphisms of interleukin (IL)-18 and IL-37 and the outcomes of HBV infection. Methods: In this study, we enrolled 300 subjects with chronic HBV infection, including those with cirrhosis/hepatocellular carcinoma (C/HCC), chronic active hepatitis B (CAH) infection, or asymptomatic carriers (AC), and 58 individuals whose infection was spontaneously cleared (SC). Genomic DNA was extracted, and IL-18/IL-37 genotyping was performed using PCR-RFLP and ARMS-PCR. Results: The frequency of genotypes and alleles of IL-18 single nucleotide polymorphisms (SNPs) at positions rs1946519, rs1946518, and rs187238 and IL-37 at position rs4241122 were not statistically different among the four studied groups (P>0.05). Furthermore, the frequency of different haplotypes was similar among the studied groups (P>0.05). Conclusions: Polymorphisms of IL-18 SNPs at positions rs1946519, rs1946518, and rs187238 and variation of IL-37 at position rs4241122 do not appear to influence the outcome of HBV infection.}, keywords = {Keywords: HBV,Polymorphism,IL-37,IL-18}, url = {https://journal.waocp.org/article_90516.html}, eprint = {https://journal.waocp.org/article_90516_c56294263d2a1d6c3df2bf73854458b8.pdf} }