eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
1
5
25087
Selection of Cases and Controls for the Nested Case-control Study within the JACC Study: the First-wave
In this paper, we describe the methodology of the case and control selection for the first-wave nested casecontrolstudy within the JACC Study. Among the subjects participating in the cohort, serum samples of 42,249subjects (including 39,242 subjects aged between 40 and 79 at the baseline) were suitable for biochemical analysis.We here selected those who had died by 1997 or who were diagnosed with cancer with sera until 1994 as cases.For each case, 3 to 4 controls with sera were randomly selected, with matching for gender, age (as near aspossible) and residential area. As a result, 3,144 cases and 10,661 controls (2,867 cases and 10,351 controls were40 to 79 years old at the baseline) were selected to measure serum IGF-I, IGF-II, IGFBP-3, TGF-β1 and sFasvalues and total SOD activity. Cases were older and more likely to be men than the JACC Study subjects.Moreover, they were much older than controls because of the age-dependence of susceptibility to death, especiallyamong men. There were more smokers among cases compared with controls, though drinkers at the baselinewere fewer. Among deceased cases, cancer was the leading cause of death, followed by cardiovascular diseases.Lung cancer was most frequent among deceased cancer cases and the next most common site was the stomach.The leading cause of cancer incidence was stomach cancer followed by lung cancer. Simple comparison of meansand distribution of IGF-I, IGF-II, IGFBP-3, TGF-β1, sFas and total SOD activity between cases and controlsrevealed total SOD activity and sFas levels of cases to be higher than controls, while for the other componentsthe opposite was found.
https://journal.waocp.org/article_25087_fde47b36e244c399903a7731d7ebf987.pdf
Japan Collaborative Cohort Study
nested case-control study
cancer mortality and incidence
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
7
22
25088
Associations of Food and Nutrient Intakes with Serum IGF-I, IGF-II, IGFBP-3, TGF-1, Total SOD Activity and sFas Levels among Middle-aged Japanese: the JACC Study
No observational study has examined whether cancer-related biomarkers are associated with diet in Japanese.We therefore assessed sex-specific food and nutrient intakes according to serum IGF-I, IGF-II, IGFBP-3, TGF-β1, total SOD activity and sFas levels, under a cross-sectional study of 10,350 control subjects who answered thefood frequency questionnaire in the first-wave nested case-control study within the Japan Collaborative CohortStudy. For both men and women, IGF-I levels were associated with higher intakes of milk, fruits, green tea,calcium and vitamin C. IGF-II levels were associated with higher intakes of milk, yogurt, fruits and miso soup,and lower intakes of rice, coffee and carbohydrate. IGFBP-3 levels were associated with higher intakes of milk,yogurt, fruits and vitamin C, and lower intakes of rice, energy, protein, carbohydrate, sodium and polyunsaturatedfatty acids. TGF-β1 levels were associated with lower intakes of coffee intakes, and higher intakes of miso soupand sodium. Total SOD activity levels were associated with lower intakes of most nutrients other than energy,carbohydrate, iron, copper, manganese, retinol equivalents, vitamin A, B2, B12, niacin, folic acid, vitamin C andfish fat. sFas levels were associated with higher intakes of manganese and folic acids. The results of the presentstudy should help to account for findings on those biomarkers regarding risks of cancer and other lifestylerelateddiseases in terms of dietary confounding as causality.
https://journal.waocp.org/article_25088_b91af9ede9eb9432b205cef5daeb4481.pdf
IGF-I/II
IGFBP-3
TGF- 1
SOD activity
sFas levels
food and nutrient intake
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
23
27
25089
Time Spent Walking or Exercising and Blood Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 (IGFBP-3): A Large-Scale Cross-Sectional Study in the Japan Collaborative Cohort Study
The preventive effects of physical activity against cancer may partly be ascribable to a possible decrease ininsulin-like growth factor-I (IGF-I) induced by the activity. To examine the association of physical activity withIGF-I and IGF-binding protein-3 (IGFBP-3), we analyzed the data for control participants in a case-controlstudy nested in the Japan Collaborative Cohort Study. A total of 3,598 men and 3,359 women throughout Japan,aged 40 to 79 years, were administered a lifestyle questionnaire and provided serum samples. The age- and bodymass index (BMI)- adjusted serum levels of IGF-I and IGFBP-3 were lower among those who walked for longertimes with a significant trend in both sexes (trend P < 0.01). Among participants who walked one hour or moreper day, the mean levels of serum IGF-I and IGFBP-3 were 138.7 ng/ml and 2.87 μg/ml in men and 125.7 ng/mland 3.14 μg/ml in women, respectively. The corresponding figures among those rarely walked were 147.4 ng/mland 2.99 μg/ml in men and 132.3 ng/ml and 3.21 μg/ml in women. For IGF-I, adjustment for serum IGFBP-3 didnot essentially alter such associations although the trend in women did not reach statistical significance. Adecreased level of serum IGF-I was associated with longer exercise time in men even after adjustment for serumIGFBP-3 (trend P = 0.033 after adjustment for age, BMI, and serum IGFBP-3), whereas the time was positivelycorrelated with serum IGF-I in women (trend P = 0.048). Our findings may partly explain the protective effectsof physical activity against several sites of cancer.
https://journal.waocp.org/article_25089_add6785aeff7fd55be17b1072479d2bd.pdf
IGF-I –
IGFBP-3 - physical activity - cancer risk
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
29
35
25090
Association of Serum Retinol and Carotenoids with Insulin-like Growth Factors and Insulin-like Growth Factor Binding Protein-3 among Control Subjects of a Nested Case-control Study in the JACC Study
Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3, modulate cell growth and survival,and thus are thought to be important for tumor development. Carotenoids and retinol have been linked to theprevention of several cancers. We here evaluated associations of serum levels of carotenoids and retinol withIGF-I, IGF-II, and IGFBP-3 within the context of the JACC Study. The study subjects were 924 controls (578men and 346 women) of a nested case-control study of lung and colorectal cancer risk . Using frozen-stored sera,serum levels of α-carotene, β-carotene, lycopene, β-cryptoxanthin, zeaxanthin/lutein, and retinol were separatelydetermined using high-performance liquid chromatography. Serum levels of IGF-I, IGF-II, and IGFBP-3 weremeasured by immuno-radiometric assay. Confounding factors-adjusted least squares mean levels of serum IGFI,IGF-II, and IGFBP-3 for each quartile of serum levels of carotenoids and retinol were estimated. Serum IGFI,IGF-II, and IGFBP-3 levels increased with increasing serum retinol levels. Moreover, serum IGF-I levels weresignificantly higher in highest quartile of serum provitamin A, such as α-carotene, β-carotene, and β-cryptoxanthin, among women. Serum IGFBP-3 levels decreased with increasing serum lycopene levels in womenand with increasing serum zeaxanthin/lutein levels in men. The current study indicates that positive associationsexist for serum retinol levels with serum levels of IGF-I, IGF-II, and IGFBP-3 independent of age, BMI, smokinghabits, drinking habits, and intake of energy and protein among Japanese healthy men and women.
https://journal.waocp.org/article_25090_9f29bae2bd5c7e488bff4267f43683b5.pdf
Japan Collaborative Cohort Study
retinol
Carotenoids
IGF-I/II
IGFBP-3
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
37
40
25091
Relationship of Serum Superoxide Dismutase Activity and Lifestyle of Healthy Japanese Adults
Superoxide dismutase (SOD) is an antioxidant enzyme that acts to degrade superoxide, a major causitivefactor for oxidative stress associated with cancer, cardiovascular disease, and various other ailments. Here, toassess an association between antioxidants and lifestyle factors related to cancer risk, we analyzed serum SODactivity among the subjects within a large-scale cohort study in Japan. As results, significant differences inserum SOD activity were found between the sexes (lower in males), among female age groups (lower in youngerindividuals), and in males with the BMI (lower in those with a high BMI). Linear increase in serum SODactivity with aging and decrease with BMI were observed in females. Significantly low SOD activity was evidentin male heavy smokers. In contrast, elevation was noted in female frequent drinkers. In conclusion, our findingsdo suggest associations between serum SOD activity and lifestyle factors. However, for further study,establishment of a standard measurement method for SOD activity should be a high priority.
https://journal.waocp.org/article_25091_4ade0f52e8a1ae897caa0d61831c0a3d.pdf
Superoxide dismutase
Lifestyle
aging
BMI
smoking
drinking alcohol
antioxidant intake
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
41
44
25092
Relationship of Soluble Fas with Body Mass Index in Healthy Japanese Adults
Recent studies have linked elevated serum sFas levels to atherosclerotic disease among patients. Confirmingan association between obesity and serum sFas levels in healthy subjects would facilitate our understanding ofobesity and its related disorders. We therefore analyzed serum sFas levels of 8,541 subjects selected as controlsfor a nested case-control study within the JACC Study. Body mass index (BMI) was calculated as the indicatorof obesity based on self-reported height and weight. We found a statistically significant positive associationbetween serum sFas levels and BMI among our apparently healthy subjects. Our result suggests that serumsFas rises to down-regulate increased apoptosis in atherogenesis processes caused by obesity.
https://journal.waocp.org/article_25092_f65416445964533be6672f81a73b41aa.pdf
Japan Collaborative Cohort Study
sFas
BMI
healthy controls
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
45
49
25093
Insulin-like Growth Factor (IGF)-I, IFG-II, IGF Binding Protein-3, and Risk of Colorectal Cancer: a Nested Case-control Study in the JACC Study
Insulin-like growth factor (IGF)-I and IGF-II are important mitogen and IGF binding protein-3 (IGFBP-3)exerts opposite effects. However, the results of epidemiological studies on cancer influence are somewhatcontroversial, and mainly from Western countries. In the present study, we therefore examined associations ofserum IGF-I, IGF-II and IGFBP-3 with colorectal cancer risk among participants in the JACC Study in Japan.After matching 3 controls to cases by sex, age, and study area, a total 101 risk sets were examined using aconditional logistic regression model adjusted for body mass index, smoking habit, alcohol consumption andfamily history of colorectal cancer. The odds ratios (and 95% CIs) for colorectal cancer mortality among thehighest tertiles of IGF-I, IGF-II, and IGFBP-3, compared to the lowest tertiles were 1.01 (0.49-2.10), 1.02 (0.55-1.91), and 1.22 (0.63-2.38), respectively. No linear trends were observed. The lack of any association was notaltered after additional adjustment for mutual markers of IGF-I/IGF-II or IGFBP-3, 0.76 (0.34–1.71) for IGFI,0.66 (0.30–1.45) for IGF-II, and 1.11 (0.47-2.66) for IGFBP-3. Our prospective data thus indicated that thereis no association of IGF-I, IGF-II, and IGFBP-3 with colorectal cancer risk in the Japanese population. Althoughthese markers might be etiologically significant in relation to colorectal cancer, we did not obtain evidencesupporting this hypothesis.
https://journal.waocp.org/article_25093_e4be0c957b30edc0631662707f0cbc15.pdf
Japan Collaborative Cohort Study
nested case-control study
colorectal cancer
IGF-I/II
IGFBP-3
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
51
55
25094
Serum Insulin-like Growth Factors I and II, Insulin-like Growth Factor Binding Protein-3 and Risk of Breast Cancer in the JACC Study
The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) was planned in the late1980s as a large-scale cohort study of persons in various areas of Japan. In the present study, we conducted anested case-control study and examined associations of breast cancer risk with serum levels of insulin-like growthfactors I and II (IGF-I, IGF-II), as well as insulin-like growth factor binding protein-3 (IGFBP-3), among womenwho participated in the JACC Study and donated their blood at the baseline. Sixty-three women who died orsuffered from breast cancer were examined. Two or three controls were selected to match each case for age atrecruitment and the study area. Controls were alive and not diagnosed as having breast cancer at the diagnosisdate of the cases. Associations between the serum IGF-I, IGF-II, IGFBP-3 and breast cancer risk were evaluatedusing a conditional logistic regression model. In premenopausal Japanese women, IGF-I showed a marginalnegative dose-dependent association with the breast cancer risk (trend P= 0.08), but any link disappeared ontaking into account IGFBP-3 (trend P= 0.47), which was likely to be inversely associated with the risk. Inpostmenopausal women, IGFBP-3 showed a marginal dose-dependent association with the risk (trend P= 0.06).Further studies are needed to confirm these findings.
https://journal.waocp.org/article_25094_b72e6770e825f0e45e9705a48ac9f67b.pdf
Japan Collaborative Cohort Study
nested case-control study
breast cancer
IGF-I
IGF-II
IGFBP-3
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
57
61
25095
Prostate Cancer Risk in Relation to Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3: A Nested Case-control Study in a Large Scale Cohort Study in Japan (JACC Study)
High levels of insulin-like growth factor (IGF)-I are reported to be associated with an increased risk ofprostate cancer. On the other hand, the insulin-like growth factor binding protein-3 (IGFBP-3) may decreasethe risk. We therefore investigated the influence of serum IGF-I and IGFBP-3 on prostate cancer risk in a casecontrolstudy nested within a large-scale cohort in Japan (the Japan Collaborative Cohort Study). Informationon lifestyles and sera of the subjects were collected in 1988-90. Serum IGF-I, IGF-II and IGFBP-3 were measuredin sera stored at -80°C by immuno-radiometric assay. In 13,508 male subjects of the cohort who donated sera,40 cases and 120 controls (1:3 matched with age and survey area) were identified. Ages of the cases ranged from59 to 79 years, with a mean of 69.8. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated forthe highest and middle tertiles compared with the lowest in controls using a conditional logistic model. NonadjustedORs for the highest tertiles were 0.99 (95% CI, 0.34-2.91) for IGF-I (trend-P = 0.60), 1.91 (95% CI,0.68-5.38) for IGFBP-3 (trend-P = 0.23), 1.73 (95% CI, 0.69–3.47) for IGF-II (trend-P = 0.23), and 0.67 (95% CI,0.26-1.76) for the IGF-I/IGBP-3 ratio (trend-P = 0.83). Serum levels of IGF-I, IGF-II, IGFBP-3, or IGF-I/IGFBP-3 ratio were thus not thought to be associated with risk of prostate cancer.
https://journal.waocp.org/article_25095_004546e7e2216cee7211d2121ddd6447.pdf
Japan Collaborative Cohort Study
nested case-control study
Prostate Cancer
IGF system
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
63
67
25096
Lack of Association between Risk of Biliary Tract Cancer and Circulating IGF (Insulin-like Growth Factor) -I, IGF-II or IGF-binding Protein-3: A Nested Case-control Study in a Large Scale Cohort Study in Japan (JACC Study)
Biliary tract cancer, encompassing gallbladder and bile duct cancers, has a poor prognosis, but little is knownof the etiology. A nested case-control study was here conducted to evaluate the association between serum levelsof IGF-I, IGF-II and IGFBP-3 and death from biliary tract cancer. In a large scale cohort study, 35 gallbladderand 42 bile duct cancers were observed during the follow-up. For each subject in the case group, 1-3 controlsubjects (228 in total) were selected randomly, matched for sex, age (as near as possible) and residential area.The subjects were divided into tertiles by circulating levels of IGF-I, IGF-II or IGFBP-3. Using conditionallogistic regression, risks among the tertiles were compared adjusted for defecation, smoking and drinking habits.No remarkable differences in risks of gallbladder or bile duct cancer were observed among tertiles of IGF-I orIGF-II, and no remarkable trend was observed. Circulating IGFBP-3 showed an inverse U-shape associationwith gallbladder cancer and a U-shaped one with bile duct cancer. Associations between IGF-I or IGF-II andgallbladder or bile duct cancer thus were lacking or very weak. The observed U- and inverse U-shaped associationof IGFBP-3 with the cancers is not suggestiveof any meaningful relationships.
https://journal.waocp.org/article_25096_4bbac87afeaf9b1426f83a8d57096f24.pdf
Japan Collaborative Cohort Study
nested case-control study
biliary tract cancer
IGF
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
69
73
25097
Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Cancer Mortality: Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study
Superoxide dismutases (SODs) are antioxidant enzymes that play a role in the defense system of the body.They may be involved in protection against carcinogenesis processes. In the present study, we investigate theassociation between serum SOD activity and the risk of deaths due to all cancers combined, based on a nestedcase-control study within the Japan Collaborative Cohort Study of 914 cancer deaths and 2,739 matched controls.Blood samples were obtained at the baseline and stored at -80ºC until analysis for SOD levels. Serum levels ofSODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model wasused to estimate odds ratios (ORs) for total cancer mortality associated with serum SOD quartile levels. Theadjusted ORs and 95% confidence intervals (CIs) for the second, third and fourth SOD quartiles were 0.96(95%CI: 0.77-1.19), 1.18 (0.92-1.51), and 1.32 (1.04-1.69), respectively. In analyses stratified by observationperiod, the adjusted ORs of the respective quartiles were 0.81 (95%CI: 0.60-1.08), 0.98 (0.70-1.37), and 1.28(0.92-1.79) for the period from the baseline to 1994; and the adjusted ORs were 1.18 (95%CI: 0.85-1.63), 1.47(1.04-2.10), and 1.41 (1.00-2.04) for the period after 1994. To conclude, we found a slightly positive associationbetween serum SOD level and the risk of all cancer mortality in the present study. Elevated serum SOD levelsmight reflect a response to oxidative stress, and then may predict a state of excess reactive oxygen species in thecarcinogenesis process. Detailed studies of associations between serum SOD levels and cancers in specific sitesshould now be performed, with attention to particular tumour types.
https://journal.waocp.org/article_25097_c565f9028643e6fb523c1c192a2ce54b.pdf
cancer mortality
JACC study
nested case-control study
superoxide dismutase activity
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
75
79
25098
Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Lung Cancer Mortality: Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study
The expression of superoxide dismutases (SODs) has been shown to differ between lung tumor and tumorfreetissues. In the present study, we investigated the association between serum SOD activity and the risk oflung cancer mortality, based on a nested case-control design study within the Japan Collaborative Cohort Study,with a sample of 193 lung cancer patients and 573 matched controls. Blood samples were obtained at the baselineand stored at -80ºC until analysis for SOD levels. Serum levels of SODs were divided into quartiles, with the firstquartile used as the reference. A conditional logistic model was used to estimate odds ratios (ORs) for lungcancer mortality associated with serum SOD quartile levels. The adjusted ORs and 95% CIs for the second,third; and fourth SOD quartiles were 0.80 (95%CI: 0.49-1.29), 1.32 (0.78-2.25), and 1.07 (0.60-1.89), respectively.In analyses stratified by observation period, the adjusted ORs of the respective quartiles were 0.56 (95%CI:0.30-1.07), 1.16 ( 0.57-2.37), and 1.11 (0.52-2.35) for the period from the baseline to 1994; and the adjusted ORsof 1.36 (95%CI: 0.65-2.85), 1.71 (0.75-3.87), and 1.06 (0.44-2.53) for the period after 1994. To conclude, wefound no significant association between serum SOD level and the risk of deaths from lung cancer in the presentstudy.
https://journal.waocp.org/article_25098_c6a692d4252688163e3748d4012ade5d.pdf
Superoxide dismutase
SOD
Lung cancer
nested case-control study
cohort study
JACC study
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
81
85
25099
Serum Soluble Fas Levels and Superoxide Dismutase Activity and the Risk of Death from Pancreatic Cancer: a Nested Case-control Study within the JACC Study
In a search for novel circulating biomarkers for pancreatic cancer, we examined the association betweenserum soluble Fas (sFas) levels and superoxide dismutase (SOD) activity and the risk of death from pancreaticcancer in a nested case-control study within the Japanese Collaborative Cohort Study. Case subjects were 68persons who were free of morbidity, had provided a blood sample at baseline (1988-1990), and subsequentlydied from pancreatic cancer before December 31, 1997. Control subjects were 199 matched persons who wereselected from the remaining participants in the cohort. Conditional logistic regression models were used toestimate age-adjusted and multivariate-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs).No statistically significant differences were noted in mean sFas levels (p=0.11) and SOD activity (p=0.42) betweencases and controls. Overall, neither serum sFas levels nor SOD activity were associated with the risk of pancreaticcancer deaths, after adjustment for area, BMI, cigarette smoking, and history of diabetes. Furthermore, nosignificant risk trends were noted. Our results do not support the hypothesis that serum sFas levels and SODactivity are associated with pancreatic cancer risk.
https://journal.waocp.org/article_25099_2f148a03786bc082e26e6a039224faaf.pdf
JACC study
nested case-control study
Pancreatic cancer
Soluble Fas
SOD
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2009-12-01
10
Supplement
87
90
25100
Serum Adiponectin Multimer Complexes and Liver Cancer Risk in a Large Cohort Study in Japan
Evidence suggests a link between adiponectin, an adipocytokine, and liver tumorigenesis. Different multimercomplexes of adiponectin, with low-molecular weight (LMW), middle-molecular weight (MMW) and highmolecularweight (HMW), may have different roles. Therefore the present study was performed with the aim ofassessing associations between these multimers and liver cancer development. A nested case-control study (59liver cancer cases [mean age=63.5 years] and 334 controls [62.7 years]) was conducted as a part of the JapanCollaborative Cohort (JACC) Study recruiting healthy participants, aged 40-79 years, for the follow-up periodfrom 1988-1990 to 1999. The end point was liver cancer occurrence/death. Serum levels of HMW, MMW andLMW adiponectin were determined at baseline using an ELISA assay. Multivariate-adjusted logistic regressionanalyses comparing the tertile levels of adiponectin multimers showed that the groups stratified with the highestpercentage of LMW tended to have lower odds ratios (ORs) than the lowest group (OR adjusted for sex, ageand area=0.54 [95%CI: 0.26-1.11] and adjusted for sex, age, area, body mass index, smoking, alcohol, coffeeconsumption, diabetes history and HCV-antibody positivity =0.50 [95%CI: 0.22-1.15]), albeit without statisticalsignificance (set at p<0.05). Higher percentages of circulating LMW adiponectin may lead to a reduction of livercancer risk and relationships with multimer composition may merit further study.
https://journal.waocp.org/article_25100_3246619b3fa7114ac34d164d192a42c5.pdf
Japan Collaborative Cohort Study
cancer
liver disease
adipocytokine