eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1891
1894
28848
Asian Cancer Registry Forum 2014 - Regional Cooperation for Cancer Registration: Priorities and Challenges
In February 6-7th, the Thai National Cancer Institute, the International Agency for Research on Cancerand its Mumbai Hub for Cancer Registration, together with the International Association of Cancer Registriesand the APOCP/APJCP, jointly organized an Asian cancer registry forum to discuss regional cooperation forcancer registration. Held in the Grande Mercure Fortune Hotel, Bangkok, the meeting brought together leadingscientists in cancer registration from South-East and North-East Asia as well as Australia, India and Iran andIARC itself, with coverage of various priorities and challenges of cancer registries regarding cancer controlpolicy, operational parameters, assessment of survival and contributions to screening, for example. The currentsituation was highlighted and future directions and possible expansion of activities were discussed, with especialattention to the necessity for networks to help improve cancer registration across Asia and Africa.
https://journal.waocp.org/article_28848_34b28fa11b333b096c5d7eacf6686d81.pdf
Cancer registration
cancer control policy
regional networks
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1895
1896
28849
What Roles should Population-based Cancer Registries be Playing in the 21st Century? Reflections on the Asian Cancer Registry Forum, Bangkok, February 2014
Cancer registries have fundamental roles in cancer surveillance, research, and health services planning,monitoring and evaluation. Many are now assuming a broader role by contributing data for health-servicemanagement, alongside data inputs from other registries and administrative data sets. These data are beingintegrated into de-identified databases using privacy-protecting data linkage practices. Structured pathologyreporting is increasing registry access to staging and other prognostic descriptors. Registry directions need tovary, depending on local need, barriers and opportunities. Flexibility and adaptability will be essential to optimizeregistry contributions to cancer control.
https://journal.waocp.org/article_28849_7b2bd49e7bec85e974a28526e3302c75.pdf
cancer registries
administrative data
data linkage
Cancer control
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1897
1904
28850
Prevention of Prostate Cancer with Vitamins - Current Perspectives
Cancer prostate is the most common solid malignancy in males of developed countries. With increasingknowledge of the aetiology, pathogenesis and natural history of the disease, influences of dietary factors onprostate cancer development have become more evident. There is ample evidence in the literature of significanceof dietary constituents for prostate cancer including vitamins A, D and E. Different vitamins have been foundto effect the growth and proliferation of prostate cancer cells as evident in epidemiological, experimental andclinical studies. Various factors play the major role in determining the relationship between these vitamins andprostate cancer in terms of environmental, pharmacological, or genetic aspects. To explore these aspects, thepresent article reviews the literature on the present status of vitamin use for prevention and management ofprostate cancer.
https://journal.waocp.org/article_28850_4b7ad120e321ecfd2c5f8c761dd9d478.pdf
Prostate Cancer
vitamins A
Vitamin D
Vitamin E
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1905
1907
28851
Ionizing Radiations Induce Apoptosis in TRAIL Resistant Cancer Cells: in vivo and in vitro Analysis
Increasingly it is being realized that despite considerable advancements in therapeutic interventions relatedto treatment of cancer, satisfactory results are still difficult to achieve. Rapidly accumulating evidence has startedto shed light on the fact that cancer cells escape from death via constitutive activation of pro-survival signalingcascades. Cell biology and genetics have extensively enhanced our current understanding of the molecularmechanisms that underlie loss of apoptosis in cancer cells. This review is focused on ionizing radiation mediatedrestoration of TRAIL mediated apoptosis as evidenced by cell culture and animal model studies. Moreover, wealso bring to the limelight radiation induced expression of miRNAs and how miRNAs further control responseof cancer cells to radiation.
https://journal.waocp.org/article_28851_f2ac140020d76e5236cff59f440ede85.pdf
ionizing radiation
TRAIL
Apoptosis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1909
1912
28852
miR-421, miR-155 and miR-650: Emerging Trends of Regulation of Cancer and Apoptosis
It is becoming progressively more understandable that between transcription and translation there liesanother versatile regulator that quantitatively controls the expression of mRNAs. Identification of miRNAs askey regulators of wide ranging signaling cascades and modulators of different cell-type and context dependentactivities attracted basic and clinical scientists to study modes and mechanisms in details. In line with thisapproach overwhelmingly increasing in vivo and in vitro studies are deepening our understanding regardingmiR-421, mir-155 and miR-650 mediated regulation of cellular activities. We also attempt to provide an overviewof long non coding RNAs.
https://journal.waocp.org/article_28852_fbea5be887d5f1aa67e5569d8ee8e0b4.pdf
miRNA
cancer
Apoptosis
signaling
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1913
1918
28853
Effectiveness of an Intervention Program on Knowledge of Oral Cancer among the Youth of Jazan, Saudi Arabia
Background: The study is the first of its kind to be conducted in Saudi Arabia (KSA), aiming to analyze theeffectiveness of an intervention program in improving the knowledge of oral cancer among the youth. Materialsand Methods: A total of 1,051 young Saudis (57% males and 43% females with a mean age of 20.4±1.98) wereselected using multi-stage cluster sampling. Knowledge assessment was accomplished using a closed-endedquestionnaire which was subjected to reliability tests. Prevalence of risk factors in relation to gender wasanalyzed using the chi-squared test. Effectiveness was calculated by comparing the pre- and post-interventionmeans, using the two-tailed paired t-test. Multiple logistic regression was employed in order to determine factorsassociated with awareness of risk habits, signs/symptoms and prevention of oral cancer. The significance level inthis study was set at 0.05. Results: Females were seen to be more into the habit of sheesha smoking (3.3% ratherthan the use of other forms of risk factors. Prevalence of diverse risk factors such as cigarette smoking (20%),sheesha (15.3%), khat (27%) and shamma (9%) was seen among males. Gender and the use of modifiable riskfactors among the study sample were significantly (p<0.001) associated with effectiveness of the intervention.The intervention program was highly effective (p<0.001) in improving the knowledge of oral cancer amongthe youth in Jazan, KSA. Multivariate analysis revealed that age and gender are the most significant factorsaffecting knowledge. Conclusions: The study gives a direction for further public health initiatives in this oralcancer prone region.
https://journal.waocp.org/article_28853_a52625000640a73121d68e8fbf5372cb.pdf
oral cancer
Prevention
knowledge assessment
Youth
Saudi Arabia
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1919
1924
28854
Screening for Breast Cancer in a Low Middle Income Country: Predictors in a Rural Area of Kerala, India
Background: In India, breast cancer is the leading malignancy among women in a majority of the cancerregistries. Therefore it is important to understand screening practices and its predictors, including in ruralareas with high female literacy and good health indices. Materials and Methods: A cross-sectional study withmultistage sampling was conducted in Vypin Block, Ernakulam district, Kerala, India. Four Panchayats (selfadministration units) were randomly chosen and a woman in every second household was invited to participatefrom the tenth ward of each. Thus a total of 809 women were interviewed. Results: The majority of the repondents(82.1%) were not aware of risk factors and about a third (37.9%) were not aware of symptoms of breast cancer.About half of the population studied (46.6%) had undergone screening. Age (35-50 years), being married, healthprofessionals as source of information and working were significant predictors of screening. Logistic regressionshowed that older women (35-50 yrs) were more likely to practice screening. Out of the never screened, about athird (35%) were desirous of doing it, but had not for various reasons and 53.5% were not willing to screen. Thereasons identified for not screening among those desirous of doing it were grouped into knowledge 66 (43.4%),resources 23 (15.1%) and psychosocial 32(21.1%) factors. Unmarried women were significantly more likely toexpress factors related to all the three domains. Conclusions: This study showed that in spite of the absence of apopulation-based screening program, about half of the study population had undergone some type of screening.The older women (35-50 years) in particular were significantly more likely to practice screening. At this criticaljuncture, a high quality breast cancer awareness and screening initiative can help to consolidate the gains andtackle knowledge, resource and psychosocial barriers.
https://journal.waocp.org/article_28854_ea6ab84020ec6295bd1133367e162606.pdf
Screening
breast cancer
Predictors
Rural India
Kerala
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1925
1929
28855
Comprehensive Analysis of Vascular Endothelial Growth Factor-C Related Factors in Stomach Cancer
Background: Vascular endothelial growth factor-C (VEGF-C), which contributes to lymphatic metastasis (LM)in malignant disease, is one of the most important factors involved in physical and pathological lymphangiogenesis.Some VEGF-C related factors such as sine oculis homeobox homolog (SIX) 1, contactin (CNTN) 1 and dualspecificity phosphatase (DUSP) 6 have been extensively studied in malignancies, but their expression levels andassociations have still to be elucidated in stomach cancer. Methods: We detected their expression levels in 30paired stomach cancer tissues using quantitative real-time reverse transcription-PCR (qRT-PCR). The expressionand clinical significance of each factor was analyzed using Wilcoxon signed rank sum test. The correlationamong all the factors was performed by Spearman rank correlation analysis. Results: The results suggest thatVEGF-C and CNTN1 are significantly correlated with tumor size, SIX1 with the age and CNTN1 also with thecTNM stage. There are significant correlations of expression levels among VEGF-C, SIX1, CNTN1 and DUSP6.Conclusions: There exists an important regulatory crosstalk involving SIX1, VEGF-C, CNTN1 and DUSP6 instomach cancer.
https://journal.waocp.org/article_28855_afa7f39376e0a04c6d15c0b025fd4efc.pdf
Stomach neoplasms
VEGFC
SIX1
CNTN1
DUSP6
crosstalk
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1931
1936
28856
Increased Expression of P2RY2, CD248 and EphB1 in Gastric Cancers from Chilean Patients
Background: Gastric cancer (GC) ranks as one of the major causes of mortality due to cancer worldwide.In Chile, it is currently the leading cause of cancer death. Identification of novel molecular markers that mayhelp to improve disease diagnosis at early stages is imperative. Materials and Methods: Using whole-genomeDNA microarrays we determined differential mRNA levels in fresh human GC samples compared to adjacenthealthy mucosa from the same patients. Genes significantly overexpressed in GC were validated by RT-PCR ina group of 14 GC cases. Results: The genes CD248, NSD1, RAB17, ABCG8, Ephb1 and P2RY2 were detected asthe top overexpressed in GC biopsies. P2RY2, Ephb1 and CD248 showed the best sensitivity for GC detectionwith values of 92.9%, 85.7% and 64.3% (p<0.05), respectively. Specificity was 85.7%, 71.4% and 71.4% (p<0.05),for each respectively.
https://journal.waocp.org/article_28856_23a57c5b8ca455e806e03c96accc14b0.pdf
Gastric cancer
Microarray
Molecular markers
P2RY2
EphB1
CD248
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1937
1941
28857
Asparagus Racemosus Leaf Extract Inhibits Growth of UOK 146 Renal Cell Carcinoma Cell Line: Simultaneous Oncogenic PRCCTFE3 Fusion Transcript Inhibition and Apoptosis Independent Cell Death
Aims: To evaluate anti-cancer activity of Asparagus racemosus (AR) leaf extract on UOK146, a renal cellcarcinoma cell line, and explore its mechanism of action. Materials and Methods: Dried AR leaves were extractedwith chloroform and dissolved in DMSO. This extract was applied to UOK146 and cell death was estimated byMTT assay. In addition PRCC-TFE3 fusion transcripts were detected by real time PCR. Results: Extract wasfound to be cytotoxic with an IC50 of 0.9 mg/ml as estimated by dose response curve. Antitumor activity of thepermissible doses of the extract was assessed by the down regulation of PRCC-TFE3 fusion transcript (38%)responsible for oncogenicity of the UOK146 cell line. No increment in the BAX, a proapoptotic marker levelwas observed. Conclusions: Evidence of antiproliferative effect, PRCC-TFE3 fusion transcript inhibition andstatic BAX level clearly indicate that AR extract provides or elicits an apoptosis independent anticancer effecton RCC cells by some specific mechanism of regulation.
https://journal.waocp.org/article_28857_edfeb4f52b5d447f1114181a6e851a3b.pdf
Immunomodulatory
PRCCTFE3
phytoestrogenic
Cytotoxicity
UOK 146
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1943
1948
28858
Clinical Determinants of Weight Loss in Patients with Esophageal Carcinoma During Radiotherapy: a Prospective Longitudinal View
Purpose: The prevalence of weight loss in esophageal carcinoma patients is high and associated withimpairment of physical function, increased psychological distress and low quality of life. It is not known whichfactors may contribute to weight loss in patients with esophageal carcinoma during radiotherapy in China. Theobjective of this study was to identify the associated demographic and clinical factors influencing weight loss.Methods: We evaluated 159 esophageal carcinoma patients between August 2010 and August 2013 in a crosssectional,descriptive study. Patient characteristics, tumor and treatment details, psychological status, adverseeffects, and dietary intake were evaluated at baseline and during radiotherapy. A multivariate logistic regressionanalyss was performed to identify the potential factors leading to weight loss. Results: 64 (40.3%) patients hadweight loss ≥5% during radiotherapy. According to logistic regression analysis, depression, esophagitis, and lossof appetite were adverse factors linked to weight loss. Dietary counseling, early stage disease and total energyintake ≥1441.3 (kcal/d) were protective factors. Conclusions It was found that dietary counseling, TNM stage,total energy intake, depression, esophagitis, and loss of appetite were the most important factors for weight loss.The results underline the importance of maintaining energy intake and providing dietary advice in EC patientsduring RT. At the same time, by identifying associated factors, medical staff can provide appropriate medicalcare to reduce weight loss. Further studies should determine the effect of these factors on weight loss and proposea predictive model.
https://journal.waocp.org/article_28858_184fada17fd4fc26e5f6047de1250567.pdf
Esophageal carcinoma
weight loss
radiotherapy
energy intake
Adverse effects
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1949
1953
28859
Modification of Cutoff Values for HE4, CA125, the Risk of Malignancy Index, and the Risk of Malignancy Algorithm for Ovarian Cancer Detection in Jakarta, Indonesia
Background: CA125 and HE4 are used in calculating Risk of Malignancy Algorithm (ROMA); and Riskof Malignancy Index (RMI). However, studies showed that normal levels of CA125, and HE4 differ amongethnicities such as between Asians and Caucasians, thus affecting the accuracy of the RMI score and ROMA inpredicting ovarian malignancy. This study aimed to determine whether new or modified cutoff values for Ca-125, HE4, the RMI score, and ROMA resulted in a better prediction of malignancy compared with the previousor standard ones. Materials and Methods: Serum level of CA125 and HE4 from 128 patients with diagnosis ofovarian tumor that had been collected before surgery at Cipto Mangunkusumo General Hospital (CMH) inJakarta from November 2010 until May 2011 were reviewed and analysed. The standard cutoff values of thesebiomarkers, RMI, and ROMA were modified by using logistic regression model. The modified cutoff values werecompared to the standard cutoff values in terms of sensitivity, specificity, and accuracy. Results: The modifiedcutoff value of CA125, HE4, RMI score and ROMA were 165.2 U/mL, 103.4 pM, 368.7, 28/54. The sensitivityand specificity of the modified cutoff values CA125, HE 4, RMI score and ROMA in differentiating benign frommalignant and borderline were 67% and 75,4%; 73.1% and 85.2%; 73.1% and 80.3%; and 77.6% and 86.9%.While the sensitivity and specificity of the standard cutoff value of CA125; HE4; RMI score; and ROMA were91% and 24.6%; 83.6% and 65%; 80.6% and 65.6%; and 91.0% and 42.6%. The accuracy of modified cutoffvalues compared with standard cutoff values were: 71.2% vs 59.3%, 78.9% vs 75% vs, 76.5% vs 73.4%, and82% vs 67.9%. Conclusions: The new or modified cutoff values of Ca125, HE4, RMI score and ROMA resultedin higher accuracy compared to the previous or standard ones, at the cost of reduced sensitivity.
https://journal.waocp.org/article_28859_90b5df54a30857de44b8858b4ad644cf.pdf
Ovarian Cancer
CA125
human epidydimis protein 4
ROMA
RMI
tumor marker cutoff values
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1955
1960
28860
Experiences of Nursing Students in Caring for Pediatric Cancer Patients
Background: This study was performed to determine the experiences of nursing students in caring forpaediatric cancer patients and their families. Materials and Methods: This qualitative survey was carried outwith 14 students studying in the nursing department of the Faculty of Health Sciences of a university in Edirne,Turkey. Data were obtained through focus group interviews and evaluated based on a qualitative content analysis.Results: It was determined that students, for the most part, experienced problems related to communication,sadness, helplessness, fear, anxiety, resentment and anger. In addition, the students were affected most often byeffects of the disease and invasive procedures on paediatric cancer patients and their families during the processof caring for them in the oncology clinic. Conclusions: It would be useful to inform nursing students, prior toclinical practice, about the special needs of paediatric cancer patients and families who stay in oncology clinics,and to follow up with appropriate guidance during the clinical practices.
https://journal.waocp.org/article_28860_ad34ef3d7dd0f1e51fecc0ce8a08f18d.pdf
Clinical practice
Nursing Student
paediatric cancer patient
experience
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1961
1970
28861
PKM2 Regulates Hepatocellular Carcinoma Cell Epithelialmesenchymal Transition and Migration upon EGFR Activation
Pyruvate kinase isozyme type M2 (PKM2) was first found in hepatocellular carcinoma (HCC), and itsexpression has been thought to correlate with prognosis. A large number of studies have demonstrated thatepithelial-mesenchymal transition (EMT) is a crucial event in hepatocellular carcinoma (HCC) and associatedmetastasis, resulting in enhanced malignancy of HCC. However, the roles of PKM2 in HCC EMT and metastasisremain largely unknown. The present study aimed to determine the effects of PKM2 in EGF-induced HCCEMT and elucidate the molecular mechanisms in vitro. Our results showed that EGF promoted EMT in HCCcell lines as evidenced by altered morphology, expression of EMT-associated markers, and enhanced invasioncapacity. Furthermore, the present study also revealed that nuclear translocation of PKM2, which is regulatedby the ERK pathway, regulated β-catenin-TCF/LEF-1 transcriptional activity and associated EMT in HCCcell lines. These discoveries provide evidence of novel roles of PKM2 in the progression of HCC and potentialtherapeutic target for advanced cases.
https://journal.waocp.org/article_28861_dd0d344dfd0cd60dd9e43991f246f353.pdf
Epithelial growth factor receptor
PKM2
β-catenin
epithelial-mesenchymal transition
HCC
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1971
1975
28862
Profile and Survival of Tongue Cancer Patients in “Dharmais” Cancer Hospital, Jakarta
Background: Tongue cancer is still a major health problem in most developing countries around the world.Statistics shown the number of tongue cancers, especially in early age, to be increasing, with poor survival.Objective: To analyze the characteristic profile of tongue cancer patients in Indonesia as well as the survivalrate. Materials and Methods: A cross sectional study was conducted in Dharmais National Cancer Hospitalby collecting general, clinical, and survival data of tongue cancer patients from medical records for January2009 to April 2012. Results: Tongue cancer incidence increased year by year. The average age of tongue cancerpatients was 47.5 years, and males predominated, accounting for 64.5% of cases. Most patients presented at anadvanced stage (69.6%). The histopathology type was squamous cell carcinoma in the vast majoriy (96.8%).The therapies applied were surgery (45.6%), radiation (63.6%) and chemotherapy (57.6%). The survival rateafter one year is 60.6% and after two years was 12.1%. In addition, median survival of tongue cancer patientswas 20 months (95% confidence interval 9.07-30.9). The significant factor affecting survival was size of tumorwith a hazard ratio of 3.18 (95% CI, 1.02-9.93; p 0.046) for largest versus smallest categories. Conclusions: Ineach year, the number of tongue cancer incidents in Indonesia is increasing. The age of tongue cancer patientsin Indonesia is younger compared to other countries. Moreover, the survival rates are not high.
https://journal.waocp.org/article_28862_8aac72f2137a8837ce427f69cd89850e.pdf
Tongue cancer
patient characteristics
survival
Indonesia
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1977
1980
28863
Fallacies about Water Pipe Use in Turksih University Students - What Might Be the Consequences?
Background: The popularity of the narghile waterpipe, also referred to as hookah, shisha or hubble-bubblehas increased tremendously during the past few decades. The aim of this study was to expose perception ofnarghile among a representative sample of university students in Sakarya University campus. Materials andMethods: Written approval was taken from the local education authority. An anonymous questionnaire which wasprepared by the investigators and contained 17 questions was administered. Nine of the questions were relatedto socio-demographic characteristics and eight were related to the students harm perceptions about waterpipe.A total of 1,320 questionnaries were received and after preliminary evaluation 1,255 (95.7%) were found to besuitable for evaluation. The data was evaluated in SPSS program by using percentages and averages. Results:The mean±SD age of the students was 20.8±2.29 years (min 18, max 32). There were 864 (68.8%) females and391 (31.2%) males. A total of 6.3 % of the students (n=79) believed that waterpipe is not harmful because itssmoke does not burn the lungs. Almost one-third (n=318) think that the carcinogenic chemicals are filtered whilewaterpipe smoke passes from the water; 12.1 % of the students (n=152) checked “true” for the statement of“waterpipe smoke contains no nicotine”. It is seen that 14.0 % of the students (n=176) think waterpipe with fruit/aroma is healthier than plain waterpipe. Conclusions: As a result of this study, it is found out that a substantialnumber of university students have false beliefs on harmful effects of waterpipe smoking.
https://journal.waocp.org/article_28863_422daeaf04eb69c588e98b97976188fa.pdf
University Students
Water pipe
fallacies
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1981
1987
28864
Prevalence and Age, Gender and Geographical Area Distribution of Esophageal Squamous Cell Carcinomas in North China from 1985 to 2006
Objective: To establish the prevalence and distribution profile of esophageal squamous cell carcinomas(ESCCs) over a 22-yr period in North China. Methods: Using endoscopy for primary diagnosis and histologicalanalysis for the further confirmation, a total of 74,854 ESCC patients aged 20-89 between January 1985 andDecember 2006 were investigated to analyze the epidemiological profile including prevalence rates, distributionof age-of-onset, gender and geographical area of ESCC in Luoyang, the highest incidence area of North China.Results: A total of 4092 cases of ESCC were finally diagnosed among 74,854 patients who had their firstendoscopies. The prevalence among males was higher than that among females (p<0.01), resulting in an overallmale:female OR of 1.2 (95%CI, 1.2–1.3). The prevalence in rural areas was higher than in urban areas (p<0.01),resulting in an overall rural:urban OR of 2.6 (95%CI, 2.4–2.9). The rural:urban ORs and the 95% CI increasedcontinuously from 2.6, 2.3-3.0 to 2.7, 2.2-3.3, respectively, for 4 consecutive periods during the 22-yr study period.Moreover, the median age of onset among females was higher than that among males (p<0.01). For both sexesand in both areas, the prevalence rates declined and the median age of onset rose for 4 consecutive periods inthe 22-yrs time frame (p<0.01). Conculsions: These data reveal the epidemiological profile of ESCC in the areaof North China, and suggest that urban areas and rural people account for a growing proportion of the ESCCpatients although the prevalence of ESCC significantly declined and the median age-of-onset postponed overthe 22-yrs period. Moreover, the prevalence status of ESCC in rural areas also underlines the need for publichealth initiatives aimed at reducing risk factors of this fatal disease.
https://journal.waocp.org/article_28864_61a4c1d15434133aa9e0cd6cd70449c1.pdf
Epidemiology
Carcinoma
esophagus
Squamous Cell Carcinoma
endoscopy urban/rural China
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1989
1992
28865
Taxane and Anthracycline Based Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer : Institutional Experience
Background: The aim of this study was to assess the response rates (clinical and pathological ) with docetaxeland epirubicin combination chemotherapy and its effect on outcome. Materials and Methods: We retrospectivelyanalysed locally advanced breast cancer (LABC) patients who received NACT from January 2008 to December2012 in our tertiary care centre. LABC constituted 37% of all breast cancer cases and 120 patients fulfilled theeligibility criteria. The regimens used for NACT were, six cycles of DEC (docetaxel 75 mg/m2, epirubicin 75 mg/m2, cyclophosphamide 500 mg/m2 on Day 1, 3 weekly) and a sequential regimen (4 cycles of FEC, 5-flurouracil600 mg/m², epirubicin 75 mg/m², cyclophosphamide 600 mg/m² followed by 4 cycles of docetaxel 85 mg/m2).Results: The median age was 47 years (range 23-72). Ninety six ( 80 %) had T4 disease and 90% had clinicallypalpable lymph nodes at diagnosis. The median size of primary tumor at presentation was 5.9 cm. Hormonereceptor positivity was seen in 55% and HER2/neu positivity, in 25%. Triple negative breast cancers constituted25 % of the cases. The overall clinical response rate ( complete or partial ) was 85% and pathological completeresponses were obtained in 15%. Four cases defaulted, 5 patients died of treatment related toxicity and 15%developed febrile neutropenia on DEC. The median duration of follow up was 22 months. The median time torelapse was 20 months and the 3 year relapse free and overall survival rates were 50% and 70% respectively.Conclusions: LABC constituted 37% of all breast cancer cases at our institute. With NACT, pCR was seenin 15% of the cases. Sequential chemotherapy was better tolerated than concurrent anthracyline and taxanechemotherapy with a similar pCR.
https://journal.waocp.org/article_28865_1dae918aa601b5c0077282a6a8081353.pdf
Breast cnacer
Chemotherapy
taxane and anthracycline
Response
outcome
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
1993
1999
28866
Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India
Background: This study aimed to explore the role of XRCC1 (Arg399Gln) and XPD (Lys751Gln) genepolymorphisms, lifestyle and environmental factors as well as their possible interactions in propensity to developlung cancer in a population with high incidence from North East India. Materials and Methods: A total of 272lung cancer cases and 544 controls were collected and XRCC1 (Arg399Gln) and XPD (Lys751Gln) genotypes wereanalyzed using a polymerase chain reaction based restriction fragment length polymorphism assay. Conditionalmultiple logistic regression analysis was used to calculate adjusted odds ratios and 95% confidence intervalsafter adjusting for confounding factors. Results: The combined Gln/Gln genotype of XRCC1 and XPD genes(OR=2.78, CI=1.05-7.38; p=0.040) was significantly associated with increased risk for lung cancer. Interactionof XRCC1Gln/Gln genotype with exposure of wood combustion (OR=2.56, CI=1.16-5.66; p=0.020), exposure ofcooking oil fumes (OR=3.45, CI=1.39-8.58; p=0.008) and tobacco smoking (OR=2.54, CI=1.21-5.32; p=0.014) andinteraction of XPD with betel quid chewing (OR=2.31, CI=1.23-4.32; p=0.009) and tobacco smoking (OR=2.13,CI=1.12-4.05; p=0.022) were found to be significantly associated with increased risk for lung cancer. Conclusions:Gln/Gln alleles of both XRCC1 and XPD genes appear to amplify the effects of household exposure, smokingand betel quid chewing on lung cancer risk in the study population.
https://journal.waocp.org/article_28866_2c3b4a55a4ef3c145ed797e8433e54bf.pdf
XRCC1
XPD
Environmental Factors
Interaction
Lung cancer
high risk population
North-East India
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2001
2006
28867
Diagnostic Significance of Combined Detection of Epstein-Barr Virus Antibodies, VCA/IgA, EA/IgA, Rta/IgG and EBNA1/IgA for Nasopharyngeal Carcinoma
The objective of this study was to investigate the diagnostic significance of EBV antibody combined detectionfor nasopharyngeal carcinoma (NPC) in a high incidence region of southern China. Two hundred and elevenuntreated NPC patients, 203 non-NPC ENT patients, and 210 healthy controls were recruited for the study. Thetiters of VCA/IgA and EA/IgA were assessed by immunoenzyme assay, and the levels of Rta/IgG and EBNA1/IgAwere determined by enzyme-linked immunosorbent assay. The levels of VCA/IgA, EA/IgA, Rta/IgG and EBNA1/IgA demonstrated no association with gender or age (p>0.05). The receiver operating characteristic curve andthe area under the curve were used to evaluate the diagnostic value. The sensitivity of VCA/IgA (98.1%) andthe specificity of EA/IgA (98.5%) were the highest. When a logistic regression model was used to combine theresults from multiple antibodies to increase the accuracy, the combination of VCA/IgA+Rta/IgG, whose areaunder the curve was 0.99, had the highest diagnostic efficiency, and its sensitivity, specificity and Youden indexwere 94.8%, 98.0% and 0.93 respectively. The data suggest that the combination of VCA/IgA+Rta/IgG may bemost suitable for NPC serodiagnosis.
https://journal.waocp.org/article_28867_269b975869de5d39e1bd661663bfd28f.pdf
Nasopharyngeal carcinoma
Epstein-Barr Virus
Antibody
Tumor marker
Serodiagnosis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2007
2011
28868
Acceptability of Human Papilloma Virus Vaccination among Women in the United Arab Emirates
Background: Human papilloma virus (HPV) is a common sexually transmitted infectious agent. It is estimatedthat 10% of all women worldwide are infected with HPV, that is some 660 million each year. HPV vaccination hasa reported efficacy of more than 98% for protection against infection in females. In 2008 the Abu Dhabi HealthAuthority in the United Arab Emirates (UAE) introduced free HPV vaccination for all eligible schoolgirls in bothpublic and private schools. Methods: A cross-sectional study of 640 women aged 18-50 years in the Emirate ofAbu Dhabi in UAE from April 2012 to October 2012 was conducted. Results: Thirty-seven percent of the womenin our sample had heard about HPV vaccination, and 80% of these would consider getting vaccinated themselves,and 87% would recommend vaccination to relatives or friends. Most women in the study (69%) had a favorableopinion about the vaccine. Only 17% of the women felt it might not be culturally acceptable, and 1% felt thatthere might be religious objections to HPV vaccination. Vaccine safety and recommendation by a doctor (36%each) were the factors identified most frequently by our sample of women which would enhance the uptake ofthe HPV vaccination. Conclusions: Knowledge about HPV vaccination among women in our sample was belowaverage (37%); however, 80% of those who had heard about HPV vaccination were willing to be vaccinatedthemselves, and 87% would recommend vaccination to relatives and friends.
https://journal.waocp.org/article_28868_d6c57344ad5c535d8614c75ce61e6328.pdf
HPV infection
HPV vaccine
cervical cancer
Women
United Arab Emirates
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2013
2020
28869
ALDH1 in Combination with CD44 as Putative Cancer Stem Cell Markers are Correlated with Poor Prognosis in Urothelial Carcinoma of the Urinary Bladder
Background: The aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is one of the promising markersfor identifying cancer stem cells in many cancer types, along with other markers including CD44. The aim ofthe present study was to evaluate the expression and clinical significance of putative cancer stem cell markers,CD44 and ALDH1A1, in a series of urothelial carcinomas of urinary bladder (UCUB) by tissue microarray(TMA). Materials and Methods: A total of 159 Urothelial Carcinomas (UC) including 96 (60%) low gradeand 63 (40%) high grade carcinomas were immunohistochemically examined for the expression of CD44 andALDH1A1. Correlations of the relative expression of these markers with clinicopathological parameters werealso assessed. Results: High level expression of ALDH1A1 was found in 16% (25/159) of bladder UC which wassignificantly correlated with increased tumor size (p value=0.002), high grade (p value<0.001), pathologic stage(T1, p value=0.007 and T2, p value<0.001) and increased rate of recurrence (p value=0.013). A high level of CD44expression was found in 43% (68/159) of cases, being positively correlated with histologic grade (p value=0.032)and recurrence (p value=0.039). Conclusions: Taken together, our results showed that ALDH1 was concurrentlyexpressed in a fraction of CD44+ tumors and its expression correlated with poor prognosis in UCs. ALDH1A1could be an ideal marker for targeted therapy of UCs in combination with conventional therapies, particularlyin patients with high grade carcinomas. These findings indicate that cells expressing ALDH1A1 along with CD44can be a potential therapeutic target in bladder carcinomas.
https://journal.waocp.org/article_28869_a685e18fd251a10ae24ad78f298fbc93.pdf
ALDH1A1
CD44
TMA
bladder carcinoma
targeted therapy
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2021
2026
28870
Prognostic Role of Nucleophosmin in Colorectal Carcinomas
Aim: Recent research suggests that nucleophosmin (NPM) may be a prognostic marker in colorectalcarcinomas (CRC). We here tested its use to predict the survival of CRC patients. Methods: We investigatedNPM expression by immunohistochemistry in histologically normal to malignant colorectal tissues and evaluatedits association with clinicopathological variables. Overall and disease-free survival after tumor removal werecalculated by the Kaplan-Meier method, and differences in survival curves were analyzed by the log-rank test.The Cox proportional hazards model was used for multivariate analysis of prognostic factors. Results: NPMexpression was found significantly upregulated in CRC compared to adjacent colorectal tissue, villous adenoma,tubular adenoma and normal colorectal mucosa (p<0.05 for all). NPM expression was statistically linked tocancer embolus, lymph node metastasis, differentiation grade, and recurrence of CRC. Overall and disease-freesurvival of NPM-negative CRC patients tended to be better than those for patients with NPM-positive lesions(log-rank statistic, p<0.05 for all). Multivariate analysis indicated NPM expression as an independent prognosticindicator for CRC patients (p<0.05 ). Conclusion: Our results suggest that NPM expression can predict thesurvival of CRC patients. Prognosis of CRC is determined by not only many known prognostic factors but alsoby NPM expression.
https://journal.waocp.org/article_28870_a0b1e2af7bdf3ee10123c4924cb52ed2.pdf
Nucleophosmin
Prognosis
colorectal carcinomas
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2027
2033
28871
Characterization of Wild-Type and Mutated RET Proto-Oncogene Associated with Familial Medullary Thyroid Cancer
Background: We aimed to assess RET proto-oncogene polymorphisms in three different Iranian familieswith medullary thyroid cancer (MTC), and performed molecular dynamics simulations and free energy stabilityanalysis of these mutations. Materials and Methods: This study consisted of 48 patients and their first-degreerelatives with MTC confirmed by pathologic diagnosis and surgery. We performed molecular dynamics simulationsand free energy stability analysis of mutations, and docking evaluation of known RET proto-oncogene inhibitors,including ZD-6474 and ponatinib, with wild-type and mutant forms. Results: The first family consisted of 27people from four generations, in which nine had the C.G2901A (P.C634Y) mutation; the second family consistedof six people, of whom three had the C.G2901T (P.C634F) mutation, and the third family, who included 12individuals from three generations, three having the C.G2251A (P.G691S) mutation. The automated 3D structureof RET protein was predicted using I-TASSER, and validated by various protein model verification programsthat showed more than 96.3% of the residues in favored and allowed regions. The predicted instability indicesof the mutated structures were greater than 40, which reveals that mutated RET protein is less thermo-stablecompared to the wild-type form (35.4). Conclusions: Simultaneous study of the cancer mutations using both insilico and medical genetic procedures, as well as onco-protein inhibitor binding considering mutation-induceddrug resistance, may help in better overcoming chemotherapy resistance and designing innovative drugs.
https://journal.waocp.org/article_28871_8109aabe513ebee97fc516dd288ec73d.pdf
Hereditary MTC
Mutation
RET proto-oncogene
In Silico
inhibitor binding
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2035
2038
28872
Lack of any Association of the CTLA-4 +49 G/A Polymorphism with Breast Cancer Risk in a North Indian Population
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is an important protein involved in the regulation of theimmune system. The +49 G/A polymorphism is the only genetic variation in the CTLA-4 gene that causes anamino acid change in the resulting protein. It is therefore the most extensively studied polymorphism among allCTLA-4 genetic variants and contributions to increasing the likelihood of developing cancer are well known invarious populations, especially Asians. However, there have hiterto been no data with respect to the effect of thispolymorphism on breast cancer susceptibility in our North Indian population. We therefore assayed genomicDNA of 250 breast cancer subjects and an equal number of age-, sex- and ethnicity-matched healthy controlsfor the CTLA-4 +49 G/A polymorphism but no significant differences in either the gene or allele frequency werefound. Thus the CTLA-4 +49 G/A polymorphism may be associated with breast cancer in other Asians, but itappears to have no such effect in North Indians. The study also highlights the importance of conducting geneticassociation studies in different ethnic populations.
https://journal.waocp.org/article_28872_f8c4de21207ecbffe776b0da1e6a5637.pdf
CTLA-4
Immunology
breast cancer
Single Nucleotide Polymorphisms
Ethnic Groups
North Indians
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2039
2044
28873
Risk of Malignancy Associated with a Maternal Family History of Cancer
This study was conducted in order to obtain a screening and early detection reference for children whosemothers had been diagnosed with cancer. Data for 276 mother-child pairs with malignant tumors were analyzed.The distribution of cancers in affected families was generally similar to that of the general Chinese population,and correspondingly breast cancer was the most common malignancy amongst daughters whose mother hadcancer (32.7%). The most prevalent cancer amongst sons with affected mothers was gastric cancer, rather thanlung cancer. Daughters were more likely to have the same kind of malignant tumor as their mother (P<0.05),and were more likely to develop breast cancer than any other malignant disease if their mother had a breasttumor (P<0.0001). Likewise, if the mother was diagnosed with breast or gynecological cancer, the daughter wasmore likely to be diagnosed with breast or gynecological cancer than any other cancer (P<0.01). Daughters andsons developed malignant diseases 11 and 6.5 years earlier than their mothers, respectively (P<0.0001).Womenwith a mother who suffered cancer should be screened for malignancy from 40 years of age especially for breast,lung, and gynecological cancers. For men with affected mothers, screening should start when they are 45 yearsold focusing particularly on lung and digestive system cancers.
https://journal.waocp.org/article_28873_0875f21e8ed10dc653da0e072e1741ed.pdf
cancer
family history
mother
son
daughter
malignant tumor
early detection
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2045
2049
28874
Functional Status in Turkish Women with Gynecological Cancer
Background: Functional status is the ability to perform daily activities. Little is known about quality of lifeand health status of gynaecological cancer patients. The present study therefore aimed to evaluate the functionalstatus of women receiving treatment for gynecological oncological disease while not hospitalised. Materials andMethods: This descriptive study covered 42 patients monitored by the Gynecological Oncology Unit in 2011.Data were collected using the Functional Living Index-Cancer and analysed with the chi square test, independentsamples t-test, Mann-Whitney U test, one-way ANOVA test and the Kruskal-Wallis H test. Results: Of the 42cases, 66.7% had been diagnosed within the previous year and 90.5% were undergoing chemotherapy. The mostsevere symptoms experienced were pain (35.7%), fatigue-weakness (40.5%) and nausea and vomiting (56.5%).Daily activities where the most difficulty was experienced were housework (28.6%), average pace walking(31.0%), carrying more than 5 kg (28.6%). The mean Functional Living Index score was quite high (103.5±24.1).FLIC-C scale scores did not vary with the educational status, diagnosis duration, and family history of cancer(p>0.05). Conclusions: Evaluation of the functional status of gynecological cancer patients and how they copewith problems should indicate to healthcare professionals what help can be given to maintain quality of life.
https://journal.waocp.org/article_28874_9916acd80478949db175f6e3b0953595.pdf
Quality of Life
cancer patients
female genital neoplasms
activities of daily living
Turkey
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2051
2055
28875
Performance of Siriraj Liquid-Based Cytology: a Single Center Report Concerning over 100,000 Samples
Background: To evaluate the performance of Siriraj liquid-based cytology (LBC) for cervical neoplasiascreening after increasing use of this technology. Materials and Methods: Cytological reports of 103,057Siriraj-LBC specimens obtained in 2007-2009 were compared with those of 23,676 specimens obtained in 2006.Results: Comparing with the year 2006, the 2007-2009 patients were slightly older (43.4±12.yr vs 42.7±12.2yr, p <0.001), and their specimens had much lower proportion of unsatisfactory slides (OR=0.06, 95%CI0.04-0.09) with comparable detection rates (3.96% vs 3.70%, p=0.052) but different proportions of variouscytological abnormalities (p<0.001). The 2007-2009 Siriraj-LBC had a negative predictive value (NPV) forcervical intraepithelial neoplasia 2+ (CIN2+) of 97.6% and an overall positive predictive value (PPV) of 43.9%.The PPV for CIN2+ varied with types of abnormal cytology, from 13.7% to 93.8% in atypical squamous cellsof undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), atypical squamouscells cannot exclude HSIL (ASC-H), high-grade squamous intraepithelial lesion (HSIL), atypical glandularcells (AGC), to squamous cell carcinoma (SCC), respectively. The PPVs for CIN2+ in ASCUS and LSIL werecomparable, but the PPV for CIN1 was higher for LSIL than for ASCUS (41.63% vs 16.32%). Conclusions:Siriraj-LBC has demonstrated a stable detection rate and NPV for CIN2+ of >95% since the first year of use.The comparable PPVs for CIN2+ of ASCUS and LSIL suggests that these two conditions may undergo similarmanagement; other cytological abnormalities need immediate evaluation.
https://journal.waocp.org/article_28875_8e3acb51fa431fffaca7f8f4fd34cce9.pdf
Cervix
Liquid-based cytology
Pap smear
squamous intraepithelial lesion
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2057
2060
28876
Lobaplatin Combined Floxuridine/Pirarubicin-based Transcatheter Hepatic Arterial Chemoembolization for Unresectable Primary Hepatocellular Carcinoma
Purpose: To assess the effect and safety of lobaplatin combinated floxuridine /pirarubicin in transcatheterhepatic arterial chemoembolization(TACE) of unresectable primary liver cancer. Patients and Methods: TACEcombined with the chemotherapy regimen was used to treat 34 unresectable primary liver cancer patients. DSA/MRI/CT/blood routine examinations were used to evaluate short term activity and toxicity after 4-5 weeks,the process being repeated if necessary. Results: Among the 34 cases, 1 (2.9%) showed a complete response, 21(61.7%) a partial response, 8 (23.5%) stable disease, and 4 progressive disease, with a total effective rate of 67.6%.The content of alpha fetoprotein dropped by over 50% in 20 cases (58.8%). The rate of recovery was hepatalgia(88.2%), ascites (47.1%), appetite (55.9%), Performance Status(30.4%). The median follow-up time (MFT) was281 days (63-558 days), and median progression-free survival was 118.5 days (95%, CI:88.8-148.2days). Adversereactions (III-IV grade) were not common, with only 4 cases of vomiting and 2 cases of thrombocytopenia (IIIgrade). Conclusions: Lobaplatin-based TACE is an effective and safe treatment for primary liver cancer.
https://journal.waocp.org/article_28876_55d9b33a4354605d5ecb979e95023e66.pdf
primary hepatic carcinoma
Chemoembolization
platinum chemotherapy
clinical response
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2061
2067
28877
Relationship Between Prognosis and Neutrophil: Lymphocyte and Platelet:Lymphocyte Ratios in Patients with Malignant Pleural Mesotheliomas
Background: It has been demonstrated that neutrophil:lymphocyte (NLR) and platelet:lymphocyte (PLR)ratios are associated with prognosis in cancer patients. The aim of this study was to investigate whetherpretreatment white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, basophil and eosinophil counts,LDH level, NLR and PLR are associated with prognosis in patients with malignant pleural mesothelioma (MPM).Materials and Methods: We retrospectively reviewed files of 50 patients who were managed with a diagnosis ofMPM between 2005 and 2010. Demographic and clinical characteristics, treatments, response to treatment andprognostic factors were evaluated, along with relationships between pretreatment blood parameters and prognosis.Results: Overall, 38 men and 12 women were included to the study. Mean age was 61.5±9.4 years (range: 39-83years). There was advanced disease in 86% (n=43) and the histological type was epithelial mesothelioma in themajority (82%). Of the cases, 17 (34%) received radiotherapy, while 42 cases underwent first- and second-linechemotherapy, with cisplatin plus pemetrexed as the most commonly used regimen. In the assessment aftertherapy, it was found that there was complete response in 4 cases (8%), partial response in 10 cases (20%),stable disease in 17 cases (34%) and progression in 19 cases (38%). Median follow-up was 10 months (range: 10day-30 months). Median overall survival was found to be 20.7 months while median progression-free survivalas 10 months. In univariate and multivariate analyses, it was found that factors significantly affecting overallsurvival included stage (p=0.030), response to treatment (p=0.026) and monocyte count (p=0.004), while factorsaffecting disease-free survival included NLR (p=0.018), response to treatment (p=0.001), and PLR score (p=0.003).Conclusions: Overall and disease-free survival was found to be better in cases with a WBC count<8.000, plateletcount<300,000, and low NLR and PLR scores in malignant pleural mesothelioma.
https://journal.waocp.org/article_28877_1f65a816e3a5b39b29c0ed1b38eea720.pdf
Malignant pleural mesothelioma
survival
NLR
PLR
Prognosis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2069
2074
28878
Population-Based Cervical Screening Outcomes in Turkey over a Period of Approximately Nine and a Half Years with Emphasis on Results for Women Aged 30-34
Purpose: To appraise the frequency of cervical cytological abnormalities in a population at normal risk viaanalysing the archive records of cytology for the period of approximately 9,5 years, comparing them with patientdemographic charecteristics, and discuss the results for women under age of 35. Materials and Methods: A totalof 32,578 cases of Pap smears were retrieved and analysed from our archive included the Pap tests performedbetween January 2001 and April 2010 at the Early Cancer Screening, Diagnosing and Education Center by theconsent of three pathologists via utilizing the Bethesda System Criteria 2001 and the results were comparedwith some demographical characteristics. Results: Our rate of the cervical cytological abnormality was 1.83%,with ASCUS in 1.18%, LSIL in 0.39, HSIL in 0.16%, AGUS in 0.07%, squamous cell carcinoma in 0.02%, andadenoarcinoma in 0.006%. Cytological abnormalities were detected mostly in those with higher age, lower parity,and premenopausal period whereas the smoking status was without influence. Bacterial vaginosis (5.6%) wasthe most frequent infectious finding (Candida albicans 2.7%; Actinomyces sp. 1.3%; and Trichomonas vaginalis0.2%) detected on the smears. The rate of abnormal cervical cytology was 9.5% among the women aged between30-34. Conclusions: Early detection of the cervical abnormalities by means of the regular cervical cancer screeningprogrammes is useful to attenuate the incidence, mortality, and morbidity of cervical cancer. Our prevalence ofthe cytological abnormalities was much lower than the one in Western populations in general but very similarto those reported from other Islamic countries that may be explained by the conservative lifestyle and the lowerprevalence of HPV in Turkey. A remarkable rate of abnormal cervical cytology of women aged 30-34 was pointedout in the present study.
https://journal.waocp.org/article_28878_9d8d4aebe0f4ce3b2a59aa0d7256fa2d.pdf
Papanicolaou Smear
cancer screening
HPV
cervical cancer
liquid based cytology
Prevention
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2075
2081
28879
Glutathione-S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Acute Leukemia Risk in Asians: a Meta-analysis
The association between glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1) and riskof acute leukemia in Asians remains controversial. This study was therefore designed to evaluate the preciseassociation in 23 studies identified by a search of PubMed and several other databases, up to December 2013.Using random or fixed effects models odds ratios (ORs) with corresponding 95% confidence intervals (CIs) werecalculated. Heterogeneity across studies was assessed, and funnel plots were constructed to test for publicationbias. The meta-analysis showed positive associations between GST polymorphisms (GSTM1 and GSTT1 butnot GSTP1) and acute leukemia risk [(OR=1.47, 95% CI 1.18-1.83); (OR=1.32, 95% CI 1.07-1.62); (OR=1.01,95% CI 0.84-1.23), respectively] and heterogeneity between the studies. The results suggested that the GSTM1null genotype and GSTT1null genotype, but not the GSTP1 polymorphism, might be a potential risk factors foracute leukemia. Further well-designed studies are needed to confirm our findings.
https://journal.waocp.org/article_28879_22eb4dd3f2d3d361306ba656c71a2c40.pdf
Acute leukemia
Glutathione-S-transferase
GST
Polymorphism
Meta-analysis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2083
2087
28880
Loss of p15INK4b Expression in Colorectal Cancer is Linked to Ethnic Origin
Colorectal cancers remain to be a common cause of cancer-related death. Early-onset cases as well as those ofvarious ethnic origins have aggressive clinical features, the basis of which requires further exploration. The aimof this work was to examine the expression patterns of p15INK4b and SMAD4 in colorectal carcinoma of differentethnic origins. Fifty-five sporadic colorectal carcinoma of Egyptian origin, 25 of which were early onset, and54 cancers of Finnish origin were immunohistochemically stained with antibodies against p15INK4b and SMAD4proteins. Data were compared to the methylation status of the p15INK4b gene promotor. p15INK4b was totally lostor deficient (lost in ≥50% of tumor cell) in 47/55 (85%) tumors of Egyptian origin as compared to 6/50 (12%)tumors of Finnish origin (p=7e-15). In the Egyptian cases with p15INK4b loss and available p15INK4b promotormethylation status, 89% of cases which lost p15INK4b expression were associated with p15INK4b gene promotorhypermethylation. SMAD4 was lost or deficient in 25/54 (46%) tumors of Egyptian origin and 28/48 (58%)tumors of Finnish origin. 22/54 (41%) Egyptian tumors showed combined loss/deficiency of both p15INK4b andSMAD4, while p15INK4b was selectively lost/deficient with positive SMAD4 expression in 24/54 (44%) tumors.Loss of p15INK4b was associated with older age at presentation (>50 years) in the Egyptian tumors (p=0.04). Thesedata show for the first time that p15INK4b loss of expression marks a subset of colorectal cancers and ethnic originmay play a role in this selection. In a substantial number of cases, the loss was independent of SMAD4 butrather associated with p15INK4b gene promotor hypermethylation and old age which could be related to differentenvironmental exposures.
https://journal.waocp.org/article_28880_c44b6702c6c650580c021f33ce5cbc3d.pdf
colorectal cancer
immunohistochemistry
methylation
p15INK4b
SMAD4
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2089
2094
28881
Could the Neutrophil to Lymphocyte Ratio be a Poor Prognostic Factor for Non Small Cell Lung Cancers?
Background: Although many prognostic factors have been identified for lung cancers, new ones are neededto determine the course of the disease. Recently, a high neutrophil to lymphocyte ratio (NLR) prior to surgeryor treatment has been shown to be an indicator of prognosis for cancer. The aim of this study was to investigatethe value of NLR as a prognostic factor and the correlation between NLR and other probable clinical prognosticfactors in non small cell lung cancer patients prior to treatment. Materials and Methods: Data of patients whowere diagnosed with non-small cell lung cancer in our institution were retrospectively reviewed. Demographicand clinicopathologic characteristics were recorded. NLR was calculated before the application of any treatment.Results: A total of 299 patients, 270 (90%) males and 29 (10%) females, were included in the study. Age (p<0.001)stage (p<0.001), Eastern Cooperative Oncology Group performance status (p<0.001), weight loss (p<0.001),anemia (p<0.001), histopatology (p<0.001), NLR ≥3 (p=0.048), NLR ≥4 (p=0.025) and NLR ≥5 (p=0.018) werefound to be the prognostic factors. Age, anemia, Eastern Cooperative Oncology Group performance status, thestage, NLR (≥5) were an independent prognostic factors. There was a positive correlation between NLR and theEastern Cooperative Oncology Group performance status (0.23, p=0.001), the C reactive protein levels (r=0.36,p<0.001). Conclusions: Prior to treatment high NLR was found as an independent poor prognosis factor. Besides,NLR correlated with Eastern Cooperative Oncology Group performance status and the C reactive protein levels.
https://journal.waocp.org/article_28881_8faa04c6a41e05bb915ab031095e84e3.pdf
Lung cancer
neutrophil to lymphocyte ratio
Prognostic factors
C Reactive Protein
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2095
2100
28882
Fulvestrant 250mg versus Anastrozole 1 mg in the Treatment of Advanced Breast Cancer: a Meta-Analysis of Randomized Controlled Trials
Objective: Most patients with advanced breast cancer experience resistance to endocrine treatment andeventual disease progression. This meta-analysis was designed to compare the efficacy and tolerability offulvestrant 250mg with anastrozole 1mg in postmenopausal women with advanced breast cancer. Methods:Electronic literature databases (Cochrane Library, Medline, and Embase) were searched for randomizedcontrolled trials (RCTs) published prior to August 2013. Only RCTs that compared fulvestrant 250mg toanastrozole 1mg in postmenopausal women with advanced breast cancer were selected. The main outcomeswere time to treatment failure (TTF), time to progression (TTP), duration of response (DOR), clinical benefitrate, and tolerability. Results: Four RCTs covering 1,226 patients (fulvestrant, n=621; anastrozole, n=605)were included in the meta-analysis. Fulvestrant increased the DOR compared to anastrozole (HR =1.31, 95%confidence interval [CI] 1.13–1.51). There was no statistically significant difference between fulvestrant andanastrozole in terms of TTF (HR=1.02, 95%CI 0.89–1.17), complete response (RR=1.79, 95%CI, 0.93–3.43),and partial response (RR=0.91, 95%CI 0.69–1.21). As for safety, there was no statistical significance betweenthe two groups for common adverse events. Conclusion: Fulvestrant 250mg is as effective and well-toleratedas anastrozole 1mg treatment for advanced breast cancer in postmenopausal women whose disease progressedafter prior endocrine treatment. Thus, fulvestrant may serve as a reasonable alternative to anastrozole whenresistance is experienced in breast cancer cases.
https://journal.waocp.org/article_28882_313241339c16bc990bbd9ce8406492e5.pdf
Fulvestrant
anastrozole
Advanced breast cancer
Meta-analysis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2101
2107
28883
Association Analysis of Single Nucleotide Polymorphisms in miR-146a and miR-196a2 on the Prevalence of Cancer in Elderly Japanese: A Case-Control Study
Background: Single nucleotide polymorphisms (SNPs) affecting microRNA (miR) sequences may influencecarcinogenesis. Our current study primarily aimed to confirm previously conducted association studies betweenrs2910164 found on miR-146a, and rs11614913 located on miR-196a2 polymorphisms and cancer phenotypesin the Japanese elderly population. rs2910164 (G/C) and rs11614913 (T/C) polymorphisms were determined bygenotyping on the samples collected from 1,351 consecutive autopsy cases registered in the Japanese SNPs forgeriatric research (JG-SNP) data base. Cancer samples were systematically reviewed, pathologically verified andassessed with respect to miR-146a and miR-196a2 genotypic variation. The current study covered 726 males and625 females with a mean age of 80.3±8.9 years. The study included 524 subjects without cancer and 827 subjectswith at least one type of cancer, such as gastric (n=160), lung (n=148), colorectal (n=116) or others. Males withcancers (n=467) were more numerous than females (n=360). Both rs11614913 (CT: TT adjusted odds ratio (OR)95% confidence interval (95%CI)=0.98 (0.75-1.28), p=0.873, CC: TT adjusted OR (95%CI)=1.06 (0.76-1.47),p=0.737, CT+CC: TT, adjusted OR (95%CI)=0.99 (0.77-1.29), p=0.990), and rs2910164 (CG: CC adjusted OR(95%CI)=1.12 (0.87-1.44), p=0.383, GG: CC adjusted OR (95%CI)=1.03 (0.71-1.48), p=0.887, CG+GG: CCadjusted OR (95%CI)=1.10 (0.87-1.39), p=0.446) polymorphisms did not show significant association with overallcancer in all subjects. However, “CC” genotype in rs11614913 polymorphism was significantly associated withincreased gastric cancer (n=160) in all subjects (CC: CT+TT, adjusted OR (95%CI)=1.50 (1.02-2.22), p=0.040).We found that rs11614913 and rs2910164 do not pose general cancer risk, but rs11614913 may influence gastriccancer in Japanese elderly population. Confirmation of our study results requires further investigations withlarger subject populations.
https://journal.waocp.org/article_28883_ac28e47e0d5362a0fb78b7a7baa7083d.pdf
MicroRNAs
rs2910164
rs11614913 SNPs
Cancer risk
Gastric cancer
elderly Japanese
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2109
2114
28884
Comfort and Anxiety Levels of Women with Early Stage Breast Cancer Who Receive Radiotherapy
Background: The aim of this planned research was to determine the comfort and anxiety levels of women withbreast cancer receiving radiotherapy. Materials and Methods: This descriptive type study covered patients thatapplied to the radiation oncology breast polyclinic of our university hospital between January and May 2011.Patient Identification Form, Radiation Therapy Comfort Questionnaire (RTCQ), Spielberger State Trait AnxietyInventory (STAI) were completed and analysed. Results: The mean age of the women who participated in thestudy was 51.6±10.4 years. Mean scores of women were 3.73±0.31 for RTCQ, 29.1±5.88 for SAI and 37.8±6.91for TAI. While the comfort levels of the women with breast cancer receiving radiotherapy were moderate, theyexperienced only low levels of anxiety. Conclusions: By determining the comfort level of the patient beforeradiotherapy, besides providing comfort in this direction, eliminating/minimizing anxiety and stress will positivelyaffect radiotherapy application. More attention of nurses to this issue is to be recommended.
https://journal.waocp.org/article_28884_66fd8cb530a7015989a3622368b44e75.pdf
breast cancer
radiotherapy
Comfort
Anxiety
Nursing
Turkey
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2115
2121
28885
Preventive Effect of Hydrazinocurcumin on Carcinogenesis of Diethylnitrosamine-induced Hepatocarcinoma in Male SD Rats
The purpose of the present study was to evaluate the preventive effects of hydrazinocurcumin (HZC) ondiethylnitrosamine (DEN)-induced hepatocarcinogenesis in a male Sprague Dawley (SD) rat model. One hundredand twenty male SD rats used in this study were divided into six groups. Those receiving DEN with curcumin(CUR) or HZC were studied compared with the DEN-alone group. The study demonstrated that DEN inducedsevere histological and immunohistochemical changes in liver tissues, significantly increasing the levels of livermarker enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase(ALP), γ-glutamyltransferase (GGT) and total bilirubin level (TBL)). The hepatocarcinoma incidenceswere 100.0%, 36.7% and 20.0% in the DEN-alone, DEN-CUR and DEN-HZC groups, respectively. Althoughmacroscopic and microscopic features suggested that both CUR and HZC were effective in inhibiting DENinducedhepatocarcinogenesis, HZC was exerted a stronger influence. Immunohistochemical analysis with PCNAdemonstrated significantly differences among the groups (all P < 0.05). Taken together, the results suggestedapplication of CUR and HZC could prevent the occurrence of carcinogenesis and HZC may be a more potentcompound for prevention of DEN-induced hepatocarcinogenesis in rats than CUR.
https://journal.waocp.org/article_28885_678406360ccc9d4d2aac2f288b7eecee.pdf
hepatocarcinoma
diethylnitrosamine
hydrazinocurcumin
curcumin
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2123
2128
28886
Ferutinin, an Apoptosis Inducing Terpenoid from Ferula ovina
A current hurdle in cancer management is the intrinsic or acquired resistance of cancer cells to chemical agentsthat restricts the efficacy of therapeutic strategies. Accordingly, there is an increasing desire to discover newnatural compounds with selective toxicity to combat malignancies. In present study, the cytotoxic and apoptosisinducingactivities of ferutinin, a terpenoid derivative from Ferula ovina, were investigated on human breast(MCF7) and bladder (TCC) cancer cells as well as normal fibroblasts (HFF3).The toxicity and DNA damageinducing effects of ferutinin were studied by MTT and comet assays, DAPI and PI staining and DNA laddering.The IC50 values of ferutinin were identified and compared with routine prescribed drugs, doxorubicin andvincristine, by MTT test. Alkaline comet assay and DAPI staining revealed DNA damage due to ferutinin, whichwas significantly (p<0.001) higher in MCF7 and TCC than HFF3 cells. Apoptosis induction was evidenced by PIstaining and DNA laddering. Our results suggest that ferutinin could be considered as an effective anticanceragent for future in vivo and clinical experiments.
https://journal.waocp.org/article_28886_e5b4993ab508f154ab8d57b07dc49f75.pdf
Anticancer
ferutinin
Apoptosis
Ferula ovina
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2129
2132
28887
Assessment of Cervical Cytological Data in Albanian Females
Background: Cervical cancer is one of the most common female malignancies with high mortality ratesin developing countries. Our purpose was to determine the prevalence of cervical cytological abnormalitiesby cervical cytology (CC) and the analysis of risk factors in Albanian population. Materials and Methods: Atotal of 5,416 conventional pap smear tests collected between January 2009 and January 2012 from TiranaUniversity Hospital Obstetrics-Gynecology “Queen Geraldine” were retrospectively analyzed. Results: A totalof 258 (4.8%) cases had epithelial abnormalities. The numbers and rates were as follows: atypical squamous cellof undetermined significance (ASCUS; n=150 [2.76%]); atypical glandular cells of undetermined significance(AGUS; n=8 [0.14%]); low-grade squamous intraepithelial lesion (LSIL; n=87 [1.6%]); high- grade squamousintraepithelial lesion (HSIL; n=10 [0.18%]); and squamous cell carcinoma (SCC; n=3 [0.05%]). Conclusions:The prevalence of cervical cytological abnormality in our study was 4.8%. A larger community-based study mayestablish the exact prevalence of malignant and premalignant lesions, so as to plan for future screening.
https://journal.waocp.org/article_28887_8f3d4c2e53389e6ba06e9e674b5293ab.pdf
Cervical abnormalities
Cytology
Pap smear
Prevalence
Albania
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2133
2139
28888
Mitochondria-mediated Apoptosis in Human Lung Cancer A549 Cells by 4-Methylsulfinyl-3-butenyl Isothiocyanate from Radish Seeds
4-Methylsulfinyl-3-butenyl isothiocyanate (MTBITC) found in the radish (Raphanus sativus L.), is a wellknownanticancer agent. In this study, the mechanisms of the MTBITC induction of cell apoptosis in humanA549 lung cancer cells were investigated. Our PI staining results showed that MTBITC treatment significantlyincreased the apoptotic sub-G1 fraction in a dose-dependent manner. The mechanism of apoptosis induced byMTBITC was investigated by testing the change of mitochondrial membrane potential (ΔΨm), the expressionof mRNAs of apoptosis-related genes by RT-PCR, and the activities of caspase-3 and -9 by caspase colorimetricassay. MTBITC treatment decreased mitochondrial membrane potential by down-regulating the rate of Bcl-2/Bax and Bcl-xL/Bax, and activation of caspase-3 and -9. Therefore, mitochondrial pathway and Bcl-2 gene familycould be involved in the mechanisms of A549 cell apoptosis induced by MTBITC.
https://journal.waocp.org/article_28888_fe501596364e2ebb0e7ce15e276cbaac.pdf
4-Methylsulfinyl-3-butenyl isothiocyanate
Apoptosis
A549 cells
mitochondrial pathways
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2141
2144
28889
A Registry Program for Familial Gastric Cancer Patients Referred to Cancer Institute of Iran
Background: Gastric cancer is the second most common cause of cancer death. It has a poor prognosis withonly 5-10% of hereditary etiology. If it is diagnosed, it could be helpful for screening the other susceptible membersof a family for preventive procedures. Usually it is identified by symptoms such as presence of cancer in differentmembers of family, some special type of pathology such as diffused adenocarcinoma, having younger age andmultiple cancer syndromes. Hence, designing a registry program can be a more practical way to screen highrisk families for a preventive program. Materials and Methods: Based on the inclusion criteria, a questionnairewas prepared. After pilot on a small number of patients, the actual data was collected from 197 patients andprocessed in SPSS 16.0. Results: Totally, 11.8% of the patients were younger than 45 years old. Blood type ‘A’ wasdominant and males had a higher risk behavior with higher consumption of unhealthy food. Adenocarcinomawas reported in majority of cases. 21.8% of the patients had the including criteria for familial gastric cancer(FGC). Conclusions: The high percentage of FGC population compared to the other studies have revealed a needto design an infrastructural diagnostic protocol and screening program for patients with FGC, plus preventiveprogram for family members at risk which could be done by a precise survey related to frequency and foundermutations of FGC in a national registry program.
https://journal.waocp.org/article_28889_56ac6d87a6fb4c3aec16201a9497b84a.pdf
Familial cancer
Gastric cancer
including criteria
cancer registry
cancer institute
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2145
2152
28890
Changed Expression of E-cadherin and Galectin-9 in Oral Squamous Cell Carcinomas but Lack of Potential as Prognostic Markers
Background: The survival rate for oral squamous cell carcinoma (OSCC) has remained generally unchangedin the past three decades, underlining the need for more biomarkers to be developed to aid prognostication andeffective management. The prognostic potential of E-cadherin expression in OSCCs has been variable in previousstudies while galectin-9 expression has been correlated with improved prognosis in other cancers. The aim ofthe present study was to investigate the expression of galectin-9 and E-cadherin in OSCC and their potentialas prognostic biomarkers. Materials and Methods: E-cadherin and Galectin-9 expression was examined byimmunohistochemistry in 32 cases of OSCC of the buccal mucosa (13 with and 19 without lymph node metastasis),as well as 6 samples of reactive lesions and 5 of normal buccal mucosa. Results: The expression of E-cadherin inOSCC was significantly lower than the control tissues but galectin-9 expression was conversely higher. MedianE-cadherin HSCOREs between OSCCs positive and negative for nodal metastasis were not significantly different.Mean HSCOREs for galectin-9 in OSCC without lymph node metastasis (127.7±81.8) was higher than OSCC withlymph node metastasis (97.9±62.9) but this difference was not statistically significant. Conclusions: E-cadherinexpression is reduced whilst galectin-9 expression is increased in OSCC. However, the present results suggestthat E-cadherin and galectin-9 expression may not be useful as prognostic markers for OSCC.
https://journal.waocp.org/article_28890_8b7e0738275c5ab461be6b6cada7138f.pdf
E-cadherin
Galectin-9
oral squamous cell carcinoma
prognostic markers
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2153
2158
28891
Alternative Messenger RNA Splicing of Autophagic Gene Beclin 1 in Human B-cell Acute Lymphoblastic Leukemia Cells
Beclin 1 is a key factor for initiation and regulation of autophagy, which is a cellular catabolic processinvolved in tumorigenesis. To investigate the role of alternative splicing of Beclin1 in the regulation of autophagyin leukemia cells, Beclin1 mRNA from 6 different types of cell lines and peripheral blood mononuclear cellsfrom 2 healthy volunteers was reversely transcribed, subcloned, and screened for alternative splicing. Newtranscript variants were analyzed by DNA sequencing. A transcript variant of Beclin 1 gene carrying a deletionof exon 11, which encoded a C-terminal truncation of Beclin 1 isoform, was found. The alternative isoform wasassessed by bioinformatics, immunoblotting and subcellular localization. The results showed that this variabletranscript is generated by alternative 3’ splicing, and its translational product displayed a reduced activity ininduction of autophagy by starvation, indicating that the spliced isoform might function as a dominant negativemodulator of autophagy. Our findings suggest that the alternative splicing of Beclin 1 might play important rolesin leukemogenesis regulated by autophagy.
https://journal.waocp.org/article_28891_62bd15d279d11b7c86f620fe2eb08ba4.pdf
Beclin 1
alternative splicing
Autophagy
Acute leukemia
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2159
2163
28892
Dietary Patterns in Relation to Prostate Cancer in Iranian Men: A Case-Control Study
Background: Prostate cancer is the most frequently occurring cancer among males in economically developedcountries. Among the several risk factors that have been suggested, only age, ethnicity, diabetes, and familyhistory of prostate cancer are well-established and primary prevention of this disease is limited. Prior studieshad shown that dietary intake could be modified to reduce cancer risk. We conducted a hospital-based, casecontrolstudy to examine the association between dietary patterns and prostate cancer risk in Iran. Materials andMethods: A total of fifty patients with prostate cancer and a hundred controls underwent face-to-face interviews.Factor analysis was used to determine the dietary patterns. Multivariate logistic regression was used to estimateodds ratios (ORs) and 95% confidence intervals (CIs). Results: We defined two major dietary patterns in thispopulation: ‘western diet’(high in sweets and desserts, organ meat, snacks, tea and coffee, French fries, salt,carbonated drinks, red or processed meat) and ‘healthy diet’ (high in legumes, fish, dairy products, fruits andfruit juice, vegetables, boiled potatoes ,whole cereal and egg). Both Healthy and western pattern scores weredivided into two categories (based on medians). Higher scores on Healthy pattern was marginally significantlyrelated to decreased risk of prostate cancer (above median vs below median, OR =0.4, 95%CI=0.2-1.0). Anincreased risk of prostate cancer was observed with the higher scores on the Western pattern (above median vsbelow median, OR=4.0, 95%CI=1.5-11.0). Conclusions: The results of this study suggested that diet might beassociated with prostate cancer among Iranian males.
https://journal.waocp.org/article_28892_6c30a28a49f5cf1cffa3f58b80d5309f.pdf
Prostate Cancer
Dietary Pattern
Case-control study
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2165
2168
28893
Awareness of Cancer Screening During Treatment of Patients with Renal Failure: A Physician Survey in Turkey
Background: Today, survival rate of patients with chronic renal failure/hemodialysis has increased so thatchronic illnesses are more likely to occur. Cancer is the main cause of morbidity and mortality in such patients.Aim: In this study, physician attitudes were examined about cancer screening in patients with renal failure.Materials and Methods: This study was done by face to face questionnaire in the 27th National NephrologyCongress to determine if the physicians dealing with chronic renal failure, hemodialysis or renal transplantedpatients, recommend cancer screening or not and the methods of screening for cervix, prostate, breast and coloncancer. Results: One hundred and fifty six physicians were included in the survey. A total of 105 (67%) participantswere male and the age of responders was 48±9 years. About 29% were specialists in nephrology, 28% internalmedicine, and 5% were other areas of expertise. Some 48% of participants were hemodialysis certified generalpractitioners. Patients were grouped as compensated chronic renal failure, hemodialysis or renal transplanted.Of the 156 responders, 128 (82%) physicians recommended breast cancer screening and the most recommendedsubgroup was hemodialysis patients (15%). The most preferred methods of screening were combinations ofmammography, self breast examination and physicianbreast examination. 112 (72%) physicians recommendedcervix cancer screening, and the most preferred method of screening was pap-smear. Colon cancer screeningwas recommended by 102 (65%) physicians and prostate screening by 109 (70%) physicians. The most preferredmethods of screening were fecal occult blood test and PSA plus rectal digital test, respectively. Conclusions: Itis not obvious whether cancer screening in renal failure patients is different from the rest of society. There isa variety of screening methods. An answer can be found to these questions as a result of studies by a commonfollow-up protocol and cooperation of nephrologists and oncologists.
https://journal.waocp.org/article_28893_3601f684014be32d288b9ee8fffbbba3.pdf
Renal failure cases
Hemodialysis
cancer screening
physician recommendations
Turkey
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2169
2177
28894
Matrine Reduces Proliferation of Human Lung Cancer Cells by Inducing Apoptosis and Changing miRNA Expression Profiles
Matrine, a main active component extracted from dry roots of Sophora flavecens , has been reported to exertantitumor effects on A549 human non-small lung cancer cells, but its mechanisms of action remain unclear. Todetermine effects of matrine on proliferation of A549 cells and assess possible mechanisms, MTT assays wereemployed to detect cytotoxicity, along with o flow cytometric analysis of DNA content of nuclei of cells followingstaining with propidium iodide to analyze cell cycle distribution. Western blotting was performed to determinedexpression levels of Bax, Bcl-2, VEGF and HDAC1, while a microarray was used to assessed changes of miRNAprofiles. In the MTT assay, matrine suppressed growth of human lung cancer cell A549 in a dose- and timedependentmanner at doses of 0.25-2.5 mg/ml for 24h, 48h or 72h. Matrine induced cell cycle arrest in G0/G1phase and decreased the G2/M phase, while down-regulating the expression of Bcl2 protein, leading to a reductionin the Bcl-2/Bax ratio. In addition, matrine down regulated the expression level of VEGF and HDAC1 of A549cells. Microarray analysis demonstrated that matrine altered the expression level of miRNAs compared withuntreated control A549 cells. In conclusion, matrine could inhibit proliferation of A549 cells, providing usefulinformation for understanding anticancer mechanisms.
https://journal.waocp.org/article_28894_bc38f1374f995817d89e8296c56a2469.pdf
Matrine
A549 lung cancer cells
miRNA profile
Apoptosis
Proliferation
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2179
2183
28895
in vitro Assessment of Antineoplastic Effects of Deuterium Depleted Water
Background: In vitro, in vivo and clinical studies have demonstrated anti-cancer effects of deuterium depletedwater (DDW). The nature of this agents action, cytotoxic or cytostatic, remains to be elucidated. We here aimedto address the point by examining effects on different cell lines. Materials and Methods: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) -based cytotoxicity analysis was conducted for human breast,stomach, colon, prostate cancer and glioblastoma multiforme cell lines as well as human dermal fibroblasts. Thecell lines were treated with decreasing deuterium concentrations of DDW alone, paclitaxel alone and both. Oneway analysis of variance (ANOVA) was used for statistical analysis. Results: Treatment with different deuteriumconcentrations of DDW alone did not impose any significant inhibitory effects on growth of cell lines. Paclitaxelsignificantly decreased the survival fractions of all cell lines. DDW augmented paclitaxel inhibitory effects onbreast, prostate, stomach cancer and glioblastoma cell lines, with influence being more pronounced in breastand prostate cases. Conclusions: DDW per se does not appear to have inhibitory effects on the assessed tumorcell lines as well as normal fibroblasts. As an adjuvant, however, DDW augmented inhibitory effects of paclitaxeland thus it could be considered as an adjuvant to conventional anticancer agents in future trials.
https://journal.waocp.org/article_28895_2f864300ed46f2992fba47319bb8b427.pdf
Deuterium depleted water
cancer cell lines
In vitro
Paclitaxel
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2185
2190
28896
Gonadotrophin Releasing Hormone Analogues for Ovarian Function Preservation in Young Females Undergoing Chemotherapy
Chemotherapy has significantly improved the prognosis of cancer patients with various malignancies. However,female patients, especially those whoich are premenopausal, suffer from significant chemotherapy induced ovarianfunction impairment, which decreases their quality of life. Many new techniques for ovarian preservation havebeen established in recent years. Although the use of gonadotrophin releasing hormone analogues (GnRHa)for this purpose is not a new concept, its effectiveness in protection of ovarian function is still debatable. Thisarticle deals with studies and metaanalyses which have been undertaken in the past, demonstrating the impactof GnRHa in ovarian function preservation, and whether their use can be implemented in routine practice.
https://journal.waocp.org/article_28896_bf025a15d554163a2054d32d7618a9b9.pdf
Hemotherapy
gonadotrophin releasing hormone analogues
ovarian failure
gonadotoxicity
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2191
2194
28897
A Systemic Analysis of S-1 Regimens for Treatment of Patients with Colon Cancer
Background: Fluorouracil-based regimens have been widely accepted and recommended in the guidelinesfor treating patients with early or advanced staged colon cancer, although results are controversial. Here weperformed a systemic analysis to evaluate the impact of S-1 based regimens on response and survival of patientswith colon cancer. Methods: Clinical studies evaluating the impact of S-1 based regimens on response andsurvival of patients with colon cancer were identified using a predefined search strategy. Summary responserates (RRs) to treatment were calculated. Results: Six clinical studies which including 227 patients with advancedcolorectal cancer were considered eligible for inclusion. Two studies were conducted using combination of S-1and Oxaliplatin, and four studies featured S-1 and irinotecan. Systemic analysis showed that, in all patients,pooled RRs was 43.17%. Major adverse effects were hematological toxicities, gastrointestinal disturbance,neurosensory toxicity. No treatment related death occurred. Conclusion: This systemic analysis suggests thatS-1 based regimens, both with oxaliplatin or irinotean are associated with acceptable response and toxicity inpatients with colon cancer.
https://journal.waocp.org/article_28897_3c6937cad3532932f96f7a41447cb316.pdf
Systemic analysis
S-1
Colon cancer
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2195
2199
28898
Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors
Background: Despite being rare in incidence, malignant tumors of major salivary glands show diversehistological variation. There are limited data on major salivary gland tumor management and outcome fromPakistan. The objective of this study was to share our experience with management of malignant tumors ofmajor salivary glands. Materials and Methods: Patients who received treatment at Shaukat Khanum CancerHospital and Research Center from July 2002 to June 2011 with an underlying diagnosis of a major salivarygland malignancy were included. Patient characteristics and treatment modalities were assessed. Local, regionaland distant failures were determined. Disease free survival (DFS) and overall survival (OS) were calculatedusing Kaplan Meier curves and the Log rank test was used to determine statistical significance. Univariate andmultivariate analyses were performed using Cox proportional hazard regression. Results: The parotid glandwas the primary site of origin in 104 (80%) patients. Mucoepidermoid carcinoma (43%) and adenoid cysticcarcinoma (24%) were the most common histological types. Surgery followed by adjuvant radiation remained themainstay treatment modality with 81 (62%) patients. Nineteen (15%) patients were treated with surgery aloneand 30 (23%) patients with locally advanced surgically inoperable tumors received radiation only. Forty one(32%) patients failed the treatment (local 12, regional 11, locoregional 5, distant 13). The expected 5 year DFSand OS were 65% and 74% respectively. On multivariate analysis, grade was the only independent predictorof DFS and nodal involvement was the only independent predictor of overall survival. Conclusions: Employingexisting standards of treatment, comparable survival can be achieved in Pakistani population with major salivarygland malignancies as elsehwere in the world.
https://journal.waocp.org/article_28898_2995ebd56b1ab76e4cd5c39d2a9b563b.pdf
salivary gland tumor
survival
Surgery
Radiation
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2201
2204
28899
Melanoma Incidence Mortality Rates and Clinico-Pathological Types in the Siberian Area of the Russian Federation
Russian rates for melanoma incidence and mortality are relatively low as compared to some other whitepopulations but the tumor is of increasing importance. In this paper, data are based on a retrospective descriptiveanalysis of melanoma epidemiology and clinicopathological characteristics in Krasnoyarsk Territory belongingto the Siberian Federal District of the Russian Federation. The age-adjusted incidence and mortality rates forthe period 1996-2009 were determined with subsequent retrospective analysis of clinicopathological data of 103primary melanoma cases. Our results showed that incidence and mortality rates in the region under considerationmatch the Russian national trends and correspond to epidemiological data of the countries of Eastern Europe.Stratification of melanoma cases by age, sex, clinicopathological state and localization revealed a prevalence oflesions on the trunk and lower extremities. Most melanomas diagnosed were of superficial spreading type andthe third Clark’s level of tumor invasion and stage II according to AJCC. In spite of comparatively low ratesof incidence and mortality the trend to increase of melanoma cases in the region under consideration obviouslycalls for more attention and further investigation.
https://journal.waocp.org/article_28899_906bf5f62a2751bacde4ec69eb5fa0ed.pdf
Melanoma
Incidence
mortality
Siberia
Russian Federation
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2205
2210
28900
Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors
Objective: To retrospectively review the clinical characteristics and analyze the prognostic factors of Chinesepatients with pulmonary neuroendocrine tumors. Materials and Methods: The clinical data of 176 patientswith pulmonary neuroendocrine tumors in Chinese PLA General Hospital from Mar., 2000 to Oct., 2012 wereretrospectively analyzed. The parameters were evaluated by univariate and multivariate analysis, including thegender, age, smoking history, family history, TNM staging, localization (central or peripheral), tumor size, nodalstatus, histological subtype and treatment (operation or non-operation). Results: There were 23 patients withtypical carcinoids (TC) (13.1%), 41 with atypical carcinoids (AC) (23.3%), 10 with large cell neuroendocrinecarcinoma (LCNEC) (5.7%) and 102 with small cell lung cancer (SCLC) (57.9%). The median follow-up time was64.5 months for AC, 38 months for LCNEC and 27 months for SCLC. The typical carcinoid censored data was 18(more than 50% of the patients), so the median follow-up time was not obtained, and actuarial 5-year survivalsfor TC, AC, LCNEC and SCLC were 75.1%, 51.7%, 26.7% and 38.8%, respectively. COX univariate analysisrevealed that the age (P=0.001), histological subtype (P=0.005), nodal status (P=0.000), treatment (P=0.000) andTNM staging (P=0.000) were the prognostic factors of the patients with pulmonary neuroendocrine tumors,whereas its multivariate analysis showed that only the age(P=0.001), TNM staging (P=0.002) and treatment(P=0.000) were independent prognostic factors. Conclusions: Radical surgery remains the treatment of choice,and is the only curative option. The age, TNM staging and treatment are confirmed to be the independentprognostic factors in multivariable models for pulmonary neuroendocrine tumors.
https://journal.waocp.org/article_28900_886fa0ae9f2f52e2a59479d2cec2f81b.pdf
Neuroendocrine tumors
carcinoid
Prognosis
small cell lung cancer
large cell neuroendocrine carcinoma
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2211
2215
28901
Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix
Background: To examine the incidence of positive vaginal surgical margins and determine the predictingfactors following radical hysterectomy for stage IB1 carcinoma of the cervix. Materials and Methods: The clinicaland histological data of 656 FIGO stage IB1 cervical cancer patients who had radical hysterectomy with bilateralpelvic lymphadenectomy (RHPL) from January 2003 to December 2012 were retrospectively reviewed andwere analyzed for their association with a positive vaginal surgical margin. A p-value of < 0.05 was consideredsignificant. Results: Thirty-five patients (5.3%) had positive vaginal surgical margins following RHPL; 24(3.7%) for intraepithelial lesions and 11 (1.7%) for carcinoma. On multivariate analysis, microscopic vaginalinvolvement by high-grade squamous intraepithelial lesion and/or carcinoma (adjusted odd ratio (OR) 186.8;95% confidence interval (CI) 48.5-718.5) and squamous histology (OR 8.7; 95% CI 1.7-44.0), were significantlyassociated with positive vaginal surgical margin. Conclusions: Microscopic vaginal involvement by HSIL and/or carcinoma are strong predictors for positive vaginal surgical margins for stage IB1 cervical cancer patientsundergoing radical hysterectomy. Preoperative ‘mapping’ colposcopy or other strategies should be consideredto ensure optimal vaginal resection.
https://journal.waocp.org/article_28901_16638bb600fef060ad6f7bbead507f3c.pdf
cervical cancer
positive vaginal margin
Radical hysterectomy
vaginal involvement
vaginal metastasis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2217
2220
28902
Survival Rate of Early Stage Endometrioid Adenocarcinoma of Endometrium Treated at Srinagarind Hospital
Purpose: To evaluate the survival outcome of early stage endometrioid adenocarcinoma of the endometriumwith risk factors for locoregional recurrence treated with combined pelvic external beam radiotherapy (EBRT)and vaginal brachytherapy (VBT) after comprehensive surgery. Materials and Methods: Post-operativeradiotherapy by pelvic EBRT and VBT for early stage endometrioid endometrial carcinoma resulted in excellentpelvic control with acceptable complications. This study showed no significant relationships between age, stage,histologic grade and LVSI and overall survival rate. Results: The 5-year overall survival rate (OS) of early stageendometrioid type of endometrial carcinoma was 85.7%. Acute toxicity occurred in 38.1% of the patients, all ofwhom were grade 1 or 2. Total late toxicity developed in 42.9% of study group, in which 36.99% of them weregrade 1-2 and 4.76% were grade 3-4. Conclusions: Post-operative radiotherapy by pelvic EBRT and VBT isacceptable for early stage endometrioid endometrial carcinoma, independent of age, stage, histologic grade andLVSI.
https://journal.waocp.org/article_28902_cec54e5b4228874730bfa24620c9fe68.pdf
Endometrial adenocarcinoma
survival
radiotherapy
Brachytherapy
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2221
2224
28903
Correlation Between Expression of Cell Adhesion Molecules CD44 v6 and E-cadherin and Lymphatic Metastasis in Nonsmall Cell Lung Cancer
Objective: To explore the relationship between expressions of cell adhesion molecules CD44 v6 and E-cadherin(E-cad) and lymphatic metastasis in non-small cell lung cancer (NSCLC). Materials and Methods: Eightyseventissue samples obtained from patients with primary NSCLC were collected in our hospital from Dec.,2007 to Dec., 2012, and the expressions of CD44 v6 and E-cad gene proteins in these samples were detected byimmunohistochemical method. Results: In the tissue without lymphatic metastasis, the positive expression rateof CD44 v6 was significantly lower, whereas the normal expression rate of E-cad was notably higher than thatwith lymphatic metastasis (55.6% vs. 78.4%, 47.2% vs. 21.6%), and both differences had statistical significance(P<0.05). Besides, CD44 v6 and E-cad expressions had a significant correlation in the NSCLC tissue with lymphaticmetastasis (P<0.05). Conclusions: The positive expression of CD44 v6 and abnormal expression of E-cad mayplay a very important role in promoting lymphatic metastasis of NSCLC, with synergistic effect. Hence, detectionof CD44 v6 and E-cad expressions is conductive to judging the lymphatic metastasis in NSCLC.
https://journal.waocp.org/article_28903_6041455ca20057d4cbbc2d66f26ab21d.pdf
CD44 v6
E-cad
non-small cell lung cancer
lymphatic metastasis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2225
2229
28904
Carcinoma of the Tongue: A Case-control Study on Etiologic Factors and Dental Trauma
Background: Carcinoma of the tongue is the most common intra-oral malignancy in Western countries.Incidence and mortality rates have increased in recent years, and survival has not improved. This study aimedto determine etiologic factors for tongue cancer with age-sex matched case-control data. Materials and Methods:47 patients with carcinoma of the tongue referred to our oral medicine clinic between years 2005-2006 wereanalyzed and compared with control group data. The medical records , including family history of cancer,dental trauma, and history of abuse of alcohol and tobacco products was recorded for all subjects. Chi squarecomparison tests and linear regression analysis were performed using the SPSS program for statistics. Results:Patient and randomly selected control groups each consisted of 30 male and 17 female subjects with mean ages53.2 (±12.6) and 52.6 (±11.5) years respectively. Smoking and alcohol abuse proportions were significantly higherin the patient group (p=0.0001, p<0.0001 respectively). Chronic mechanical trauma was observed in 44.7% of thepatients and 17.0% of the control group (p=0.004). Similarly, family history of cancer of any type (for the firstdegree relatives) was found to be more common in the patient group (p=0.009). On regression analysis, alcoholabuse, family history of cancer, smoking, chronic mechanical traumas appeared as significant etiologic factors(p=0.0001). Conclusions: We believe that field cancerization may become evident in oral and oropharyngealmucosa with multiple steps of molecular changes starting from the first sign of dysplasia with chronic exposureto etiological factors. Chronic trauma cases need particular attention to search for very early signs of cancer.
https://journal.waocp.org/article_28904_55f371cf0983ec80d149475fc57fa6c6.pdf
Tongue cancer
etiologic factors
dental trauma
field cancerization
dysplasia
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2231
2238
28905
Associations of Self-rated Health and Socioeconomic Status with Information Seeking and Avoiding Behavior among Post-Treatment Cancer Patients
This study investigated how self-rated health and socioeconomic status are associated with behaviour ofcancer survivors regarding desire for information. For this association, we compared survivors who did notseek information about cancer with those who did. We examined how sociodemographic, socioeconomic, cancerrelated,and health information factors are associated with self-rated health (SRH) by health information seeking/avoiding behavior in a survey of 502 post-treatment cancer patients. In the information seeking group, all fourfactors exhibited significant relationships with SRH. SRH values were significantly high for women (p<0.05),non-Hispanic White (p<0.05), and educated (p<0.01) participants, and for those who had high self-efficacy to usehealth information by themselves (p<0.01). Furthermore, in the information avoiding group, not only were thereno significant relationships between socioeconomic status (SES) and SRH, but there were negative associationsbetween their attitude/capacity and the SRH. In terms of communication equity, the promotion of informationseeking behavior can be an effective way to reduce health disparities that are caused by social inequalities.Information avoiding behavior, however, does not exhibit a negative contribution toward the relationship betweenSRH and SES. Information seeking behavior was positively associated with SRH, but avoiding behavior wasnot negatively associated. We thus need to eliminate communication inequalities using health intervention tosupport information seeking behavior, while simultaneously providing support for avoiders.
https://journal.waocp.org/article_28905_b2cf1115b1362be129fc6587b2f5cf0b.pdf
Health information seeking
health information avoidance
self-rated health
health communication
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2239
2244
28906
Effects of Secondary Left-sided Portal Hypertension on the Radical Operation Rate and Prognosis in Patients with Pancreatic Cancer
Objective: To investigate the effects of secondary left-sided portal hypertension (LSPH) on the radical operationrate of patients with pancreatic cancer and systemically evaluate the prognosis of patients with LSPH secondaryto pancreatic cancer after radical surgery. Materials and Methods: The data of patients with pancreatic cancerwho underwent laparotomy over a 15-year period in Department of Hepatobiliary Surgery of Chinese PLA AirForce General Hospital from Jan. 1, 1997, to Jun. 30, 2012 was retrospectively reviewed. Results: A total of 362patients with pancreatic cancer after laparotomy were selected, including 73 with LSPH and 289 without LSPH.Thirty-five patients with LSPH (47.9%) and 147 without non-LSPH (50.9%) respectively underwent radicaloperations. No significant difference was found between these two groups regarding the total resection rate andstratified radical resection rate according to different pathological types and cancer locations. The mean andmedian survival time of patients after radical operation in LSPH group were 13.9±1.3 months and 14.8 months,respectively, while those in non-LSPH group were 22.6±1.4 months and 18.4 months, respectively(P<0.05).Conclusions: Radical operations for pancreatic cancer and secondary LSPH are safe and effective. Becausehigh-grade malignancy and poor prognosis are closely associated, the decision for radical surgery should bemade more meticulously for the patients with pancreatic cancer.
https://journal.waocp.org/article_28906_800b2f31a7f40479f5796b5166dcdf93.pdf
Left-sided portal hypertension
Pancreatic cancer
radical operation
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2245
2249
28907
Detection of Human Papillomavirus DNA in Routine Cervical Scraping Samples: Use for a National Cervical Cancer Screening Program in a Developing Nation
Background: Human papillomavirus is a well-established cause of the development of a variety of epitheliallesions in the cervix. However, as yet, incorporation of HPV testing into cervical cancer screening either as anadjunct or stand alone test is limited due to its cost. We therefore here ascertained the presence and type specificityof human papilloma virus (HPV) DNA in routine cervical scrapings. Materials and Methods: Cervical scrapingswere collected from women attending clinics for routine Pap smear screening. HPV-DNA was detected by PCRusing MY09/11 and GP5+/GP6+ primer sets and genotyping was accomplished by cycle-sequencing. Results: Atotal of 635 women were recruited into the study with mean±SD age of 43±10.5 years. Of these 92.6% (588/635)were reported as within normal limits (WNL) on cytology. The presence of HPV infection detected by nestedMY/GP+-PCR was 4.4% (28/635). The overall prevalence of high-risk HPV (HR-HPV) in abnormal Pap smearswas 53.8% (7/13). HPVs were also seen in 3.1% (18/588) of smears reported as WNL by cytology and 5.9%(2/34) in smears unsatisfactory for evaluation. Conclusions: The overall percentage of HPV positivity in routinecervical screening samples is comparable with abnormal findings in cytology. Conventional Pap smear ‘missed’a few samples. Since HPV testing is expensive, our results may provide valuable information for strategisingimplementation of effective cervical cancer screening in a country with limited resources like Malaysia. If Papsmear coverage could be improved, HPV testing could be used as an adjunct method on cases with ambiguousdiagnoses.
https://journal.waocp.org/article_28907_ba82c263bcc5ae58dc80d1b13c522a39.pdf
HPV-DNA detection
Cytology
PCR
cervical cancer screening
Developing country
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2251
2255
28908
Clinical Value of Dividing False Positive Urine Cytology Findings into Three Categories: Atypical, Indeterminate, and Suspicious of Malignancy
Background: The aim of this study was to evaluate 10 years of false positive urine cytology records, alongwith follow-up histologic and cytologic data, to determine the significance of suspicious urine cytology findings.Materials and Methods: We retrospectively reviewed records of urine samples harvested between January 2002and December 2012 from voided and catheterized urine from the bladder. Among the 21,283 urine samplesobtained during this period, we located 1,090 eligible false positive findings for patients being evaluated for thepurpose of confirming urothelial carcinoma (UC). These findings were divided into three categories: atypical,indeterminate, and suspicious of malignancy. Results: Of the 1,090 samples classified as false positive, 444 (40.7%)were categorized as atypical, 367 (33.7%) as indeterminate, and 279 (25.6%) as suspicious of malignancy. Patientswith concomitant UC accounted for 105 (23.6%) of the atypical samples, 147 (40.1%) of the indeterminatesamples, and 139 (49.8%) of the suspicious of malignancy samples (p<0.0001). The rate of subsequent diagnosisof UC during a 1-year follow-up period after harvesting of a sample with false positive urine cytology initiallydiagnosed as benign was significantly higher in the suspicious of malignancy category than in the other categories(p<0.001). The total numbers of UCs were 150 (33.8%) for atypical samples, 213 (58.0%) for indeterminatesamples, and 199 (71.3%) for samples categorized as suspicious of malignancy. Conclusions: Urine cytologyremains the most specific adjunctive method for the surveillance of UC. We demonstrated the clinical value ofdividing false positive urine cytology findings into three categories, and our results may help clinicians bettermanage patients with suspicious findings.
https://journal.waocp.org/article_28908_009a612fea1a6dab9cf672148e116f85.pdf
Urine cytology
false positive
Urothelial carcinoma
Diagnosis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2257
2262
28909
C1420T Polymorphism of Cytosolic Serine Hydroxymethyltransferase and Risk of Cancer: a Meta-analysis
A series of studies have explored the role of cytosolic serine hydroxymethyltransferase (SHMT1) C1420Tpolymorphism in cancer risk, but their results were conflicting rather than conclusive. To derive a moreprecise estimation of the association between C1420T and cancer risk, the present meta-analysis of 28 availablestudies with 15,121 cases and 18,023 controls was conducted. The results revealed that there was no significantassociation between the polymorphism and cancer risk overall. In stratified analysis by cancer type (breast cancer,gastrointestinal cancer, leukemia, lymphoma, and others), the results showed that 1420T allele was associatedwith decreased risk in leukemia (CT vs. CC: OR= 0.825, 95% CI =0.704-0.966; and CT+TT vs. CC: OR= 0.838,95% CI = 0.722-0.973), but the same results were not present for other cancer types. When subgroup analysiswas performed by source of control (population-based [PB] and hospital-based [HB]), a borderline inverseassociation was observed for the HB subgroup (CT vs. CC: OR= 0.917, 95% CI = 0.857-0.982) but not for thePB subgroup. Stratifying by geographic area (America, Asia and Europe), significant inverse association wasonly found in Asia subgroup (CT vs. CC: OR= 0.674, 95% CI = 0.522-0.870). In summary, the findings suggestthat SHMT1 C1420T polymorphism is not associated with overall cancer development, but might decreasecancer susceptibility of Asians as well as reduce leukemia risk. Large well-designed epidemiological studies willbe necessary to validate the risk identified in the current meta-analysis.
https://journal.waocp.org/article_28909_65002a4427d98917aaa882039fe2006e.pdf
Cancer - meta-analysis - C1420T - SHMT1 –
polymorphism - susceptibility
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2263
2266
28910
Efficacy of Postoperative Bladder Irrigation with Water for Injection in Reducing Recurrence Rates of Non Muscle Invasive Bladder Cancer
The aim of the study was to investigate the results of bladder irrigation with Water for Injection (WFI)after transurethral resection of bladder tumours for comparison with those for adjuvant use of BCG. A total of239 patients (158 with single tumours, group A, and 81 with multiple tumours, group B) received continuousintravesical postoperative irrigation with WFI. Some 128 patients received intravesical irrigation with WFI,followed by weekly instillations of BCG (group C). Recurrence-free rate (RFR) and recurrence-free intervals(RFI) were recorded. RFR for those patients who received only intravesical irrigation with WFI (groups A andB) was 75.8%, 66.2% and 63.2% at the 1st, 2nd and 3rd year of follow up, respectively. Corresponding ratesfor group C were 61.7%, 55.4% and 49%. Median RFI in group B were 18, 11, 15, 15 and 12 months for Ta, T1,grade 1, grade 2 and grade 3 tumours, respectively. In group C corresponding intervals were 20, 33, 8, 20 and 42months. BCG improved RFR only in T1 (p=0.014) and grade 3 tumours (p=0.007). In conclusion, postoperativebladder irrigation with WFI could increase RFR during the first and second year of follow up.
https://journal.waocp.org/article_28910_a275007eabcce48c5d29c9e6a8acfc91.pdf
Bladder Tumors
BCG
tumor recurrence
bladder irrigation
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2267
2272
28911
Breast, Cervix and Colorectal Cancer Knowledge among Nurses in Turkey
Background: Cancer is one of the most common causes of death in Turkey. Nurses are essential providersof preventive care for patients, especially breast, cervical and colorectal cancer screening as part of routinepreventive practice. The aim of this study was to assess knowledge of these cancers among nurses in KarabukState Hospital. Materials and Methods: This cross-sectional and descriptive study was performed from April 1to July 30, 2013. The study sample consisted of 226 nurses working in Karabuk State Hospital. Results: Meanage of the nurses was 32.07±8.39. 62.4% of nurses practiced breast self examination when they remembered it,while 39.8% of them did not take a Pap smear test since they did not think it was necessary. 64.2% of nurseswould like to receive information about cancer and screening tests. Majority of them had given true answersto questions on breast, cervical and colorectal cancer. There were significant relationships between cancerknowledge scores and marital status, working experience, and level of education. Conclusions: Nurses possessadequate knowledge about breast cancer but they need more information on cancer risk estimation. Awarenessmay be raised in nurses by establishing continuing education programs regarding the risk factors, symptoms,protection methods, early diagnosis, and scanning of breast, cervix and colon cancers.
https://journal.waocp.org/article_28911_4d16fc28b6d4ac448a0e7f975acf5118.pdf
breast cancer
cervical cancer
colorectal cancer
cancer screening programs
Knowledge
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2273
2278
28912
Bioinformatics Analysis Reveals Significant Genes and Pathways to Targetfor Oral Squamous Cell Carcinoma
Purpose: The purpose of our study was to explore the molecular mechanisms in the process of oral squamouscells carcinoma (OSCC) development. Method: We downloaded the affymetrix microarray data GSE31853 andidentified differentially expressed genes (DEGs) between OSCC and normal tissues. Then Gene Ontology (GO)and Protein-Protein interaction (PPI) networks analysis was conducted to investigate the DEGs at the functionlevel. Results: A total 372 DEGs with logFC| >1 and P value < 0.05 were obtained , including NNMT, BAX,MMP9 and VEGF. The enriched GO terms mainly were associated with the nucleoplasm, response to DNAdamage stimuli and DNA repair. PPI network analysis indicated that GMNN and TSPO were significant hubproteins and steroid biosynthesis and synthesis and degradation of ketone bodies were significantly dysregulatedpathways. Conclusion: It is concluded that the genes and pathways identified in our work may play critical rolesin OSCC development. Our data provides a comprehensive perspective to understand mechanisms underlyingOSCC and the significant genes (proteins) and pathways may be targets for therapy in the future.
https://journal.waocp.org/article_28912_9f8d439a7f9872b835e4ff95a54ac05b.pdf
Bioinformatics
Oral SCC
differentially expressed genes
protein-protein interactions
pathways
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2279
2285
28913
Long Term Outcomes of Patients with Endometrial Carcinoma Treated with Radiation - Siriraj Hospital Experience
Background: To evaluate treatment outcomes of patients with stage I-III endometrial cancer treated withpostoperative radiation. Materials and Methods: A retrospective review of 166 endometrial cancer patients,undergoing surgery and postoperative radiotherapy at Siriraj Hospital from 2005-2008 was performed. Pathologywas reviewed. Results of treatment were reported with 5-year loco-regional recurrence free survival (LRRFS),5-year overall survival (OS), patterns of failure and toxicity, and according to stage and risk groups. Results:Median follow up time was 62.8 months. Pathological changes were found in 36.3% of the patients after centralreviews, leading to 19% changes in risk groups. Most of the patients (83.7%) received pelvic radiation (PRT)and vaginal brachytherapy (VBT). Five-year LRRFS and OS of all patients were 94.9% and 85.5%, respectively.There was no recurrence or death in low and low-intermediate risk groups. For the high-intermediate risk group,5-year LRRFS and OS were 96.2% and 90.8%, respectively, and for the high risk group 90.5% and 71%. Lategrade 3 and 5 gastrointestinal toxicity was found in 3% and 1.2% of patients, respectively. All of them receivedPRT 5,000 cGy in 25 fractions. Conclusions: Low and intermediate risk patients had good results with surgeryand adjuvant radiation therapy. For high risk patients, postoperative radiation therapy alone appeared to beinadequate as the most common pattern of failure was distant metastasis.
https://journal.waocp.org/article_28913_2dc4caecd646e032a6a7d7774a7fd80f.pdf
endometrial carcinoma
Radiation therapy
survival
central pathological review
FIGO 2009
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2287
2290
28914
Lack of Metformin Effects on Different Molecular Subtypes of Breast Cancer under Normoglycemic Conditions: An in vitro Study
Background: In the past few years, a considerable number of preclinical studies have been proposed metforminas a potential anticancer agent, but some of these studies suffer from a number of methodological limitationssuch as assessment of cytotoxicity in the presence of supraphysiological glucose concentrations or applyingsuprapharmacological levels of the drug. These objections have limited the translation of published preclinicaldata to the clinical setting. The present study aimed to investigate direct anticancer effects of metformin ondifferent molecular subtypes of breast cancer with pharmacological concentrations and under normoglycemicconditions in vitro. Materials and Methods: Breast cancer cell lines from luminal A, luminal B, ErbB2 andtriple-negative molecular subtypes were treated with a pharmacological concentration of metformin (2mM)at a glucose concentration of 5.5mM. Time-dependant cell viability was assessed by dye exclusion assay. MTTbasedcytotoxicity assays were also performed with metformin alone or in combination with paclitaxel. Results:Metformin did not show any growth inhibitory effects or time-dependant cytotoxicity on breast cancer cell linesin the presence of normal glucose concentrations at the therapeutic plasma level. No augmentation of the antineoplasticproperties of paclitaxel was apparent under the tested conditions. Conclusions: Metformin is probablyunable to exert cytotoxic or cytostatic effects on breast cancer subtypes at pharmacological concentrations andnormal plasma glucose levels. These results highlight the importance of establishing a higher steady-state plasmaconcentration of metformin in the clinical setting for assessment of anticancer effects i n normoglycemic patients.
https://journal.waocp.org/article_28914_36aaffa78e09ba8f91241de24aeb5f7b.pdf
breast cancer
Metformin
Cytotoxicity
In vitro
normoglycemia
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2291
2295
28915
In vitro Study of Nucleostemin as a Potential Therapeutic Target in Human Breast Carcinoma SKBR-3 Cells
Although nucleolar protein nucleostemin (NS) is essential for cell proliferation and early embryogenesisand expression has been observed in some types of human cancer and stem cells, the molecular mechanismsinvolved in mediation of cell proliferation and cell cycling remains largely elusive. The aim of the present studywas to evaluate NS as a potential target for gene therapy of human breast carcinoma by investigating NS geneexpression and its effects on SKBR-3 cell proliferation and apoptosis. NS mRNA and protein were both foundto be highly expressed in all detected cancer cell lines. The apoptotic rate of the pcDNA3.1-NS-Silencer group(12.1-15.4±3.8%) was significantly higher than those of pcDNA3.1-NS (7.2-12.0±1.7%) and non-transfectiongroups (4.1-6.5±1.8%, P<0.01). MTT assays showed the knockdown of NS expression reduced the proliferationrate of SKBR-3 cells significantly. Matrigel invasion and wound healing assays indicated that the number ofinvading cells was significantly decreased in the pcDNA3.1-NS-siRNA group (P<0.01), but there were no significantdifference between non-transfected and over-expression groups (P>0.05). Moreover, RNAi-mediated NS downregulationinduced SKBR-3 cell G1 phase arrest, inhibited cell proliferation, and promoted p53 pathway-mediatedcell apoptosis in SKBR-3 cells. NS might thus be an important regulator in the G2/M check point of cell cycle,blocking SKBR-3 cell progression through the G1/S phase. On the whole, these results suggest NS might be atumor suppressor and important therapeutic target in human cancers.
https://journal.waocp.org/article_28915_4c52f5f36a13d2745c75ea0c906d21cc.pdf
Nucleostemin
RNA interference
SKBR-3 cells
Proliferation
Apoptosis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2297
2302
28916
Meta Analysis of Treatment for Stage IE~IIE Extranodal Natural Killer /T Cell Lymphomas in China
Objective: To evaluate early treatment for extranodal natural killer/T cell lymphoma (ENK/TCL) in Chinaand provide reference for clinical treatment of these patients. Methods: Computer-based retrieval was performedin PubMed, CNKI, CBM, VIP and WanFang Data to search for randomized controlled trials (RCTs) of treatmentfor early ENK/TCL, and a meta-analysis was conducted with RevMan 5.0 software. Results: A total of 11 RCTs,including 871 patients, were selected, of which the first radiotherapy had a higher complete response (CR) thanthe first chemotherapy [OR=14.16, 95%CI (8.68, 23.10), P<0.00001] and CR was not different between combinedtreatment group and radiotherapy group [OR=1.86, 95%CI (0.47, 3.58), P=0.61], but long-term survival ratewas higher with combined treatment[OR=1.88, 95%CI (1.09, 3.19), P=0.02]. No difference in survival rate wasobserved between radio-chemotherapy and chemo-radiotherapy groups [OR=1.11, 95%CI (0.73, 1.69), P=0.63].Conclusions: Radiotherapy is of great significance in the treatment of early ENK/TCL, but combined therapycould further enhance long-term survival rate of patients. This conclusion still requires further confirmationusing RCTs with high quality and large sample size.
https://journal.waocp.org/article_28916_d78d347ed295b8318c8606c8c933cae9.pdf
Extranodal natural killer/T cell lymphoma
radiotherapy
Chemotherapy
RCT
Meta Analysis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2303
2307
28917
Clinicopathologic Patterns of Adult Renal Tumors in Pakistan
Background: Renal cancer is a serious public health problem which may be under reported and registeredin our setup, since the Karachi cancer registry documented only 43 cases out of 4,268 incident cancer cases over3 year duration. Therefore we aimed to determine the clinicopathologic characteristics of adult renal tumors inour setup. Materials and Methods: The study was conducted in histopathology department, Liaquat NationalHospital and included total of 68 cases of adult renal tumors over 4 years. Detailed histopathologic characteristicsof tumors were analyzed. Results: Mean age of patients was 56.4 (18-84) years. Renal cell carcinoma (RCC) wasthe most common cell type (78%) cases; followed by transitional/urothelial carcinoma (12.5%), leiomyosarcoma(4.7%), oncocytoma (1.6%), squamous cell carcinoma (1.6%) and high grade pleomorphic undifferentiatedsarcoma (1.6%). Among 50 RCC cases; 62% were conventional/clear cell RCC (CCRCC) type followed bypapillary RCC(PRCC), 24%; chromophobe RCC(CRCC), 6% and sarcomatoid RCC(SRCC), 8%. Mean tumorsize for RCC was 7.2 cm. Most RCCs were intermediate to high grade (60% and 40% respectively). Capsularinvasion, renal sinus invasion, adrenal gland involvement and renal vein invasion was seen in 40%, 18%, 2% and10% of cases respectively. Conclusions: We found that RCC presents at an earlier age in our setup compared toWestern populations. Tumor size was significantly larger and most of the tumors were of intermediate to highgrade. This reflects late presentation of patients after disease progression which necessitates effective measuresto be taken in primary care setup to diagnose this disease at an early stage.
https://journal.waocp.org/article_28917_66b10172844af0c57b95310e723816b7.pdf
Renal tumors
renal cell carcinoma
clear cell RCC
chromophobe RCC
papillary RCC
Pakistan
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2309
2312
28918
Identification of a Novel Fusion Gene (HLA-E and HLA-B) by RNA-seq Analysis in Esophageal Squamous Cell Carcinoma
Esophageal squamous cell carcinoma (ESCC) is the most common histologic subtype of esophageal cancerand is characterized by a poor prognosis. Determining gene changes in ESCCs should improve understandingof putative risk factors and provide potential targets for therapy. We sequenced about 55 million pair-endreads from a pair of adjacent normal and ESCC samples to identify the gene expression level and gene fusion.Sanger sequencing was used to verify the result. About 17 thousand genes were expressed in the tissues, of whichapproximately 2400 demonstrated significant differences between tumor and adjacent non tumor tissue. GO andKEGG pathway analysis revealed that many of these genes were associated with cellular adherence and movement,simulation responses and immune responses. Notably we identified and validated one fusion gene, HLA-E andHLA-B, located 1 MB apart. We also identified thousands of remarkably expressed transcripts. In conclusion,a novel fusion gene HLA-E and HLA-B was identified in ESCC via whole transcriptome sequencing, whichwould be a biomarker for ESCC diagnosis and target for therapy, shedding new light for better understandingof ESCC tumorigenesis.
https://journal.waocp.org/article_28918_93a1546aea42f86e6d665e173b9521cf.pdf
RNA-Seq
ESCC
gene fusion
HLA-E
HLA-B
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2313
2318
28919
Ubiquitination of p53 is Involved in Troglitazone Induced Apoptosis in Cervical Cancer Cells
Peroxisome proliferator-activated receptor gamma (PPAR-γ), a ligand-dependent nuclear transcription factor,has been found to widely exist in tumor tissues and plays an important role in affecting tumor cell growth. Inthis study, we investigated the effect of PPAR-γ on aspects of the cervical cancer malignant phenotype, such ascell proliferation and apoptosis. Cell growth assay, Western blotting, Annexin V and flow cytometry analysisconsistently showed that treatment with troglitazone (TGZ, a PPAR-γ agonist) led to dose-dependent inhibition ofcervical cancer cell growth through apoptosis, whereas T0070907 (another PPAR-γ antagonist???) had no effecton Hela cell proliferation and apoptosis. Furthermore, we also detected the protein expression of p53, p21 andMdm2 to explain the underlying mechanism of PPAR-γ on cellular apoptosis. Our work, finally, demonstratedthe existence of the TGZ-PPAR-γ-p53 signaling pathway to be a critical regulator of cell apoptosis. These resultssuggested that PPAR-γ may be a potential therapeutic target for cervical cancer.
https://journal.waocp.org/article_28919_80b3040766bd96aba9e4798180661e1c.pdf
Cervix
PPAR-γ
troglitazone
p53
ubiquitination of p53
Apoptosis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2319
2321
28920
GSTT1 is Deregulated in Left Colon Tumors
Our aim was to determine GSTT1 expression levels in left colon tumors and paired normal tissue in orderto identify specific alterations in GSTT1 mRNA levels. Alterations in GSTT1 expression in twenty-four leftsidedcolon tumors and paired cancer free tissue were determined by qRT-PCR. Significant fold changes weredetermined with t-test. When compared with cancer free tissue, left colon cancers showed a significant decreasein GSTT1 expression. However, GSTT1 mRNA levels among different grades increased gradually in correlationwith tumor grade. Our results suggest that downregulation of GSTT1 in left-sided colon cancers is an early eventand is reversed with cancer progression, probably due to cellular defense mechanisms as a response to changesin the microenvironment.
https://journal.waocp.org/article_28920_baf23421b76b1bcfd148a0628a969d87.pdf
Deregulation
GSTT1 expression
left colon cancer
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2323
2328
28921
Lack of Effects of Dietary Folate Intake on Risk of Breast Cancer: An Updated Meta-analysis of Prospective Studies
Background: Epidemiological findings are controversial relating to the relationship between dietary folateintake and the risk of breast cancer. We therefore conducted a meta-analysis of prospective cohort studies toclarify this association. Materials and Methods: PUBMED, EMBASE, and MEDLINE databases were searchedfor all relevant literature published in English from January 1, 1966 to August 2013. Summary relative risk(RR) and 95% confidence intervals (CIs) were calculated using a fixed or random effects model. Results: Dietaryfolate intake was not significantly associated with the risk of breast cancer. The combined RR with 95%CI forthe highest vs. lowest category dietary intake of folate [fifteen studies; 1,836,566 participants and 24,083 patientswith breast cancer] was 0.98 (0.90-1.05). Among subgroup analysis by menstrual status, hormonal status andthe consumption of alcohol, methionine and vitamin B12, no significant association was observed for the dietaryintake of folate and the risk of breast cancer. Dose-response analysis showed that a 220 μg/day increment indietary folate intake was not associated with the risk of breast cancer. Conclusions: Our findings indicate thatdietary folate intake has no significant effect on the risk of breast cancer.
https://journal.waocp.org/article_28921_b6bbaf70b89c0e1fad089c4ce7dcb641.pdf
Folate
breast cancer
Meta-analysis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2329
2334
28922
Curcumin Inhibits MHCC97H Liver Cancer Cells by Activating ROS/TLR-4/Caspase Signaling Pathway
Curcumin can inhibit proliferation of liver cancer cells by inducing apoptosis, but the specific signalingpathways involved are not completely clear. Here, we report that curcumin inhibited proliferation of MHCC97Hliver cancer cells by induction of apoptosis in a concentration dependent manner via stimulating intracellularreactive oxygen species (ROS) generation. Also, we showed that increased intracellular ROS formation activatedthe TLR-4/MyD-88 signaling pathway, resulting in activation of caspase-8 and caspase-3, which eventually ledto apoptosis in MHCC97H cells. These results showed that as an prooxidant, curcumin exerts anti-cancer effectsby inducing apoptosis via the TLR-4/MyD-88 signaling pathway.
https://journal.waocp.org/article_28922_d9c646f4d0a8827bb3c07e4a290d8fac.pdf
curcumin
Liver cancer
reactive oxygen species
Toll-Like Receptor 4
Apoptosis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2335
2340
28923
Development of Polymeric Nanopaclitaxel and Comparison with Free Paclitaxel for Effects on Cell Proliferation of MCF-7 and B16F0 Carcinoma Cells
Paclitaxel is hydrophobic in nature and is recognized as a highly toxic anticancer drug, showing adverse effectsin normal body sites. In this study, we developed a polymeric nano drug carrier for safe delivery of the paclitaxelto the cancer that releases the drug in a sustained manner and reduces side effects. N-isopropylacrylamide/vinyl pyrrolidone (NIPAAm/VP) nanoparticles were synthesized by radical polymerization. Physicochemicalcharacterization of the polymeric nanoparticles was conducted using dynamic light scattering,transmission electron microscopy, scanning electron microscopy and nuclear magnetic resonance, whichconfirmedpolymerization of formulated nanoparticles. Drug release was assessed using a spectrophotometer andcell viability assays were carried out on the MCF-7 breast cancer and B16F0 skin cancer cell lines. NIPAAm/VP nanoparticles demonstrated a size distribution in the 65-108 nm range and surface charge measured -15.4mV. SEM showed the nanoparticles to be spherical in shape with a slow drug release of ~70% in PBS at 38°Cover 96 h. Drug loaded nanoparticles were associated with increased viability of MCF-7 and B16F0 cells incomparison to free paclitaxel. Nano loaded paclitaxel shows high therapeutic efficiency by sustained releaseaction for the longer period of time, i increasing its efficacy and biocompatibility for human cancer therapy.Therefore, paclitaxel loaded (NIPAAm/VP) nanoparticles may provide opportunities to expand delivery of thedrug for clinical selection.
https://journal.waocp.org/article_28923_6a206594e28cea3371d78edab81e94cf.pdf
NIPAAm/VP nanoparticles
Paclitaxel
sustain drug delivery
cancer cell lines MCF-7
B16F0
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2341
2344
28924
Clinicopathologic and Diagnostic Significance of p53 Protein Expression in Papillary Thyroid Carcinoma
Background: p53 protein expression has been detected immunohistochemically in papillary thyroidcarcinoma(PTC). We investigated the relations between its expression and clinicopathologic features and itssignificance as a diagnostic marker. Materials and Methods: We compared and evaluated 93 patients in whomthyroidectomy with lymph node dissection had been performed to treat PTC for clinicopathologic significanceand 102 patients with 23 papillary thyroid overt carcinomas (POC), 57 papillary thyroid microcarcinomas(PMC),5 follicular adenomas (FA), 5 Hashimoto’s thyroiditis (HT) and 12 nodular hyperplasias (NH) for significanceas a diagnostic marker. Expression of p53 protein was evaluated immunohistochemically in sections of paraffinembeddedtissue. Results: Statistical analysis showed significantly different expression of p53 in PTC versusother benign thyroid lesions (BTL).The diagnostic sensitivity and specificity were 85.0% and 72.7%, respectively.Overexpression of p53 protein was observed in 44 of the 93 PTC cases (47.3%), but no significant correlationbetween p53 protein overexpression and clinicopathologic features (age, size, multiplicity, lymph node metastasis,extrathyroidal extension and vascular invasion) was noted. Conclusions: p53 is valuable to distinguish PTC fromother BTL, but there is no correlation between p53 protein overexpression and clinicopathologic features.
https://journal.waocp.org/article_28924_2b9c05b0e8a4c6b7b9a4ad192a2bad7e.pdf
Papillary Thyroid Carcinoma
p53 protein
clinicopathologic significance
diagnostic marker
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2345
2351
28925
Protein-protein Interaction Network Analyses for Elucidating the Roles of LOXL2-delta72 in Esophageal Squamous Cell Carcinoma
Lysyl oxidase-like 2 (LOXL2), a member of the lysyl oxidase (LOX) family, is a copper-dependent enzyme thatcatalyzes oxidative deamination of lysine residues on protein substrates. LOXL2 was found to be overexpressedin esophageal squamous cell carcinoma (ESCC) in our previous research. We later identified a LOXL2 splicingvariant LOXL2-delta72 and we overexpressed LOXL2-delta72 and its wild type counterpart in ESCC cellsfollowing microarray analyses. First, the differentially expressed genes (DEGs) of LOXL2 and LOXL2-delta72compared to empty plasmid were applied to generate protein-protein interaction (PPI) sub-networks. Comparisonof these two sub-networks showed hundreds of different proteins. To reveal the potential specific roles of LOXL2-delta72 compared to its wild type, the DEGs of LOXL2-delta72 vs LOXL2 were also applied to construct a PPIsub-network which was annotated by Gene Ontology. The functional annotation map indicated the third PPIsub-network involved hundreds of GO terms, such as “cell cycle arrest”, “G1/S transition of mitotic cell cycle”,“interphase”, “cell-matrix adhesion” and “cell-substrate adhesion”, as well as significant “immunity” relatedterms, such as “innate immune response”, “regulation of defense response” and “Toll signaling pathway”. Theseresults provide important clues for experimental identification of the specific biological roles and molecularmechanisms of LOXL2-delta72. This study also provided a work flow to test the different roles of a splicingvariant with high-throughput data.
https://journal.waocp.org/article_28925_e68115418923a970bdbfdc9132129d9e.pdf
LOXL2-delta72
Protein-protein interaction
network comparison
Esophageal SCC
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2353
2358
28926
Influence of Ionizing Radiation on Ovarian Carcinoma SKOV-3 Xenografts in Nude Mice under Hypoxic Conditions
Purpose: We aimed to detect the expression of HIF-1α, VEGF, HPSE-1 and CD31 in SKOV3 xenografts innude mice treated with different doses of ionizing radiation, trying to explore the possible mechanism of hypoxiaand radioresistance. Methods: Nude mice bearing SKOV3 xenografts were randomly divided into 4 groups:Group A (control group, no ionizing radiation), Group B (treated with low dose of ionizing radiation: 50cGy),Group C (treated with high dose of ionizing radiation: 300cGy), Group D ( combined ionizing radiation, treatedwith ionizing radiation from low dose to high dose : 50cGy first and 300cGy after 6h interval). The mRNAlevels of HIF-1 and VEGF in each group were detected by real time polymerase chain reaction, while HPSE-1expression was measured by ELISA. The microvessel density (MVD) and hypoxic cells were determined throughimmunohistochemical (IHC) staining of CD31 and HIF-1a. Results: Significant differences of HIF-1α mRNA levelcould be found among the 4 groups (F=74.164, P<0.001): Group C>Group A>Group D> Group B. The mRNAlevel of VEGF in Group C was significantly higher than in the other three groups (t=-5.267, P=0.000), while nosignificant difference was observed among Group A, B and D (t=1.528, 1.588; P=0.205, 0.222). In addition, theMVD was shown to be the highest in Group C (t=6.253, P=0.000), whereas the HPSE-1 level in Group A waslower than in Group B (t=14.066, P=0.000) and higher than in Group C (t=-21.919, P=0.000), and similar withGroup D (t=-2.066, P=0.058). Through IHC staining of HIF-1a, the expression of hypoxic cells in Group A was(++), Group B was (+), Group C was (+++) and Group D was (+). Conclusion: Ionizing radiation with lowerdosesmight improve tumor hypoxia through inhibiting the expression of HIF-1 and HPSE-1, whereas higherdosesworsen tumor hypoxic conditions by up-regulating HIF-1α, HPSE-1, VEGF and CD31 levels. A protocolof low-dose ionizing radiation followed by a high-dose irradiation might at least partly improve tumor hypoxiaand enhance radiosensitivity.
https://journal.waocp.org/article_28926_e10f307318356a9d0e3c584c8b55211c.pdf
ionizing radiation
hypoxia inducible factor 1
Vascular Endothelial Growth Factor
CD31
HPSE-1
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2359
2362
28927
Effects of Thermotherapy on Th1/Th2 Cells in Esophageal Cancer Patients Treated with Radiotherapy
Background: To investigate the effects of double radiofrequency hyperthermia on Th1/Th2 cells in esophagealcancer patients treated with radiotherapy. Materials and Methods: 22 patients with esophageal cancer weredivided into a radiotherapy group (10 cases) and a combined group (double radiofrequency hyperthermiacombined with radiotherapy group, 12 cases). Both groups received conventional radiotherapy using a cobalt-60therapy apparatus (TD60-66Gy/30-33F). Patients in the combined group also underwent double radiofrequencyhyperthermia (2F/W, 8-10F). Before and after treatment, Th1, Th2, Tc1 and Tc2 cells in peripheral bloodwere determined with flow cytometry. Results: In the radiotherapy group, Th1 cell contents before and afterradiotherapy were 17.5±5.26% and 9.69±4.86%, respectively, with a significant difference (p<0.01). The Th1/Th2ratio was significantly decreased from 28.2±14.3 to 16.5±10.4 (p<0.01). In the combined group, Th1 cell contentbefore radiotherapy was 15.9±8.18%, and it increased to 18.6±8.84 after radiotherapy (p>0.05), the Th1/Th2ratio decreasing from 38.4±36.3 to 28.1±24.0 (p>0.05). Changes in Th2, Tc1 and Tc2 cell levels were not significantin the two groups before and after therapy (p>0.05). Conclusions: Double radiofrequency hyperthermia canpromote the conversion from Th2 to Th1 cells, and regulate the balance of Th1/Th2 cells.
https://journal.waocp.org/article_28927_b6fbd1db5255af82afcef994ad9d0c53.pdf
Esophageal Cancer
double radiofrequency hyperthermia
radiotherapy
Th1
Th2
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2363
2367
28928
The NAD(P)H: Quinine Oxidoreductase 1 (NQO1) Gene 609 C>T Polymorphism is Associated with Gastric Cancer Risk: Evidence from a Case-control Study and a Meta-analysis
The association between the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene C609T polymorphism(rs1800566) and gastric cancer has been widely evaluated, but a definitive answer is so far lacking. We firstconducted a case-control study to assess this association in a large Han Chinese population, and then performeda meta-analysis to further address this issue. Although our case-control association study indicated no significantdifference in the genotype and allele distributions of C609T polymorphism between gastric cancer patientsand controls, in the meta analysis involving 4,000 subjects, comparison of alleles 609T and 609C indicated asignificantly increased risk (46%) for gastric cancer (95% confidence interval (95%CI) for odds ratio (OR)=1.20-1.79) in individuals with the T allele. The tendency was similar to the homozygote (OR=1.81, 95%CI: 1.16-2.84),dominant models (OR=1.41, 95%CI: 1.12-1.79), as well as recessive model (OR=1.58, 95%CI: 1.06-2.35). Stratifiedanalysis by study design demonstrated stronger associations in population-based than in hospital-based studies.And ethnicity-based analysis demonstrated a significant association in Asians. We conclude that the NQO1 geneC609T polymorphism increases the risk for gastric cancer, especially in Asian populations.
https://journal.waocp.org/article_28928_d536a51af2088c8830962a9eabad0801.pdf
Gastric cancer
NQO1 gene
Polymorphism
risk
Meta-analysis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2369
2374
28929
Efficacy and Safety of Selumetinib Compared with Current Therapies for Advanced Cancer: a Meta-analysis
Background and Aim: Selumetinib is a promising and interesting targeted therapy agent as it may reverseradioiodine uptake in patients with radioiodine-refractory differentiated thyroid cancer. We conduct this metaanalysisto compare the efficacy and safety of selumetinib with current therapies in patients with advancedcancer. Methods: An electronic search was conducted using PubMed/ Medicine, EMBASE and Cochrane librarydatabases. Statistical analyses were carried out using either random-effects or fixed-effects models according tothe heterogeneity of eligible studies. Results: Six eligible trials involved 601 patients were identified. Comparedwith current therapies, treatment schedules with selumetinib did not improve progression free survival (hazardratio, 0.91; 95%CI 0.70–1.17, P= 0.448), but did identify better clinical benefits (odds ratio, 1.24; 95%CI 0.69–2.24, P = 0.472) and less disease progression (hazard ratio, 0.72; 95%CI 0.51–1.00, P = 0.052) though its impactwas not statistically significant. Sub-group analysis resulted in significantly improved progression free survival(hazard ratio, 0.61; 95%CI 0.49–0.57, P = 0.00), clinical benefits (odds ratio, 3.04; 95%CI 1.60–5.77, P = 0.001)and reduced disease progression (hazard ratio, 0.35; 95%CI 0.18–0.67, P = 0.001) in patients administratedselumetinib. Dermatitis acneiform (risk ratio, 9.775; 95%CI 3.143–30.395, P = 0.00) and peripheral edema (riskratio, 2.371; 95%CI 1.690–3.327, P = 0.00) are the most frequently observed adverse effects associated withselumetinib. Conclusions: Compared with current chemotherapy, selumetinib has modest clinical activity asmonotherapy in patients with advanced cancer, but combinations of selumetinib with cytotoxic agents in patientswith BRAF or KRAS mutations hold great promise for cancer treatment. Dermatitis acneiform and peripheraledema are the most frequently observed adverse effects in patients with selumetinib.
https://journal.waocp.org/article_28929_dc684a24a60132251751857208240ae2.pdf
MEK1/2 inhibitor
selumetinib
advanced cancer
Meta-analysis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2375
2378
28930
Importance of Volumetric Measurement Processes in Oncology Imaging Trials for Screening and Evaluation of Tumors as Per Response Evaluation Criteria in Solid Tumors
Cancer, like any disease, is a pathologic biological process. Drugs are designed to interfere with the pathologicprocess and should therefore also be validated using a functional screening method directed at these processes.Screening for cancers at an appropriate time and also evaluating results is also very important. Volumetricmeasurement helps in better screening and evaluation of tumors. Volumetry is a process of quantification of thetumors by identification (pre-cancerous or target lesion) and measurement. Volumetric image analysis allowsan accurate, precise, sensitive, and medically valuable assessment of tumor response. It also helps in identifyingpossible outcomes such disease progression (PD) or complete response as per Response Evaluation Criteria inSolid Tumors (RECIST).
https://journal.waocp.org/article_28930_f08478ebd05786ace031272142184ae3.pdf
cancer
Screening
evaluation
volumetric measurements
RECIST
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2379
2381
28931
Anthocyanins: Targeting of Signaling Networks in Cancer Cells
It is becoming progressively more understandable that phytochemicals derived from edible plants haveshown potential in modelling their interactions with their target proteins. Rapidly accumulating in-vitroand in- vivo evidence indicates that anthocyanins have anticancer activity in rodent models of cancer. Moreintriguingly, evaluation of bilberry anthocyanins as chemopreventive agents in twenty-five colorectal cancerpatients has opened new window of opportunity in translating the findings from laboratory to clinic. Confluenceof information suggests that anthocyanins treated cancer cells reveal up-regulation of tumor suppressor genes.There is a successive increase in the research-work in nutrigenomics and evidence has started to shed lighton intracellular-signaling cascades as common molecular targets for anthocyanins. In this review we bring tol imelight how anthocyanins induced apoptosis in cancer cells via activation of extrinsic and intrinsic pathways.
https://journal.waocp.org/article_28931_461e055bbc01eb841e2778463d4935d0.pdf
Apoptosis
Anthocyanins
signaling
cancer
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2383
2391
28932
Tobacco Cessation in India: How Can Oral Health Professionals Contribute?
Tobacco use is described as the single most preventable cause of morbidity and mortality globally, with theWorld Bank predicting over 450 million tobacco-related deaths in the next fifty years. In India, the proportion ofall deaths that can be attributed to tobacco use is expected to rise from 1.4% in 1990 to 13.3% in 2020 of whichsmoking alone will cause about 930,000 adult deaths by 2010. Many studies have shown that counseling froma health professional is an effective method of helping patients quit the tobacco habit. Tobacco cessation needsto be urgently expanded by training health professionals in providing routine clinical interventions, increasingavailability and subsidies of pharmacotherapy, developing wide-reaching strategies such as quitlines, and costeffectivestrategies, including group interventions. The WHO Framework Convention on Tobacco Control(FCTC) emphasizes the vital contribution of participation of health professional bodies, as well as training andhealthcare institutions in tobacco control efforts. Dentists can play an important role in helping patients quitusing tobacco. One of the key strategies to reduce tobacco-related morbidity and mortality is to encourage theinvolvement of health professionals in tobacco-use prevention and cessation counselling. The dental office isan ideal setting for tobacco cessation services since preventive treatment services, oral screening, and patienteducation have always been a large part of the dental practice.
https://journal.waocp.org/article_28932_5a9d4f2ad6d9f8de4fa77de12558fe61.pdf
Morbidity
mortality - framework convention on tobacco control - tobacco cessation services
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2014-05-01
15
5
2393
2394
28933
Has the Neutrophil/Lymphocyte Ratio a Predictive Role in Distinguishing Neoplastic Potential of Colonic Polyps?
https://journal.waocp.org/article_28933_5cec6241f35d1693cce350311bef9937.pdf