eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1151
1154
10.22034/APJCP.2018.19.5.1151
63012
Indicators of Evaluating Research at Article Level:Recommendation for Effective Evaluation of APJCP’ Scientific Performances
Alireza Mosavi-Jarrahi
journal@waocp.org
1
Porya Keihani
2
Esmaeil Vaziri
evaziri@ut.ac.ir
3
Mansoureh Feizabadi
feizabadi_mns@yahoo.com
4
School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
Department of Computer Science and Research Branch, Islamic Azad University, Mashhad, Iran.
Department of Information Science and Knowledge Studies, Faculty of Literature and Humanities, University of Zabol, Zabol, Iran.
Information Science and Knowledge Studies, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Today, research is seen as an investment to promote innovation and maintain sustainable social-economic developmentin all societies. The growth of scientific products and the expansion of knowledge in different scientific fields haveentailed more attention to assessments and the impact evaluation of both outcome and process of researchers in all fields.In light of this need, policymakers in the medical field have paid more attention to evaluating the outcomes of researchin terms of its impact on the society using many different indicators. In this short communication, the performance ofscholarly published scientific products are discussed and the indicators that measure such impacts are evaluated andrecommendation is given to APJCP’ editorial board on how to align its activities toward achieving better impact andscientometric measures for the journal.
https://journal.waocp.org/article_63012_a7d4ad42cf8bf8eede40d15a1121b2e4.pdf
research evaluation
Altmetrics
Article level metrics
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1155
1155
10.22034/APJCP.2018.19.5.1155
60725
Increased Risk of Penile Cancer among Men Working in Agriculture: Some Methodological Issues
Mostafa Dianatinasab
dianati.epid@gmail.com
1
Mahmoud Khodadost
mahmodkhodadost@yahoo.com
2
Aria Dianatinasab
dianati.aria@gmail.com
3
Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran.
Department of Epidemiology, Faculty of Health, Iran University of Medical Sciences, Tehran, Iran.
Department of Biochemistry, Student research committee, Shiraz University of Medical Sciences, Shiraz, Iran.
https://journal.waocp.org/article_60725_0a7d57d27e94ba9f64983189e3d44798.pdf
Penile cancer
Epidemiology
risk factors
Methodological Issue
descriptive studies
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1157
1160
10.22034/APJCP.2018.19.5.1157
62619
NCI Summer Curriculum in Cancer Control and Prevention – A Practice Changing Course for Oncologists from Limited Resource Country Like India
Abhishek Shankar
doc.abhishankar@gmail.com
1
Rakesh Thakur
2
Nandu Meshram
3
Keduovinuo Keditsu
4
Priya Srinivas
5
Department of Preventive oncology, Dr B R Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Delhi, India.
Toronto Public Health, Toronto, Canada.
Society for Oral Cancer and Health, Bramhapuri, India.
Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.
Cancer has become an important public health issue in India. Oncologists in India spends most of their time indiagnosis and treatment of cancer patients. There is a large disparity geographically as far as cancer treatment facilitiesare concerned. Cancer control and cancer prevention is not a point of concern for most of the practicing oncologist.Although things are changing in India, but orientation, passion and dedication towards cancer prevention is still missing.There is no program on basic principles and practice of cancer control and prevention in India which addresses theessence of cancer control and prevention. Center for Global Health of National Cancer Institute, USA initiated summercurriculum is an excellent academic program to teach health care professionals working in cancer care in different partsof world. This covers all aspect of cancer care i.e. cancer education, epidemiology, screening, diagnosis, treatmentand the before world palliative care with dedicated session on upcoming molecular prevention in cancer. This givesan unique opportunity for learning and can be practice changing curriculum for many of the attendees who want topursue a career in cancer control and prevention a before practice.
https://journal.waocp.org/article_62619_ecd382ae7b9e12c335270924212b4946.pdf
NCI Summer Curriculum
Cancer Prevention
India
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1161
1167
10.22034/APJCP.2018.19.5.1161
62653
Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and Treatments
Tahereh Nosratzehi
taherehnosratzahi@yahoo.com
1
Dental Research Center and Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
Oral lichen planus (OLP) is an immune-related disorder with unknown exact etiology but established prevalencein females. There are six clinical forms of OLP, ranging from asymptomatic white keratotic lesions to painful erosionsand ulcerations. The aim of the present report is to overview pathologic and therapeutic aspects. Peroxidation products,antioxidants, cortisol, and immunoglobulins are potential biomarkers to predict OLP occurrence. The risk of OLPdevelopment in patients with hepatitis B and C infection is 2-fold greater than in healthy individuals, while there is nosignificant relation with diabetes mellitus. Corticosteroids are common drugs to treat OLP and their combination withother agents can be most effective. Folic acid and variants of vitamin B are also potential treatments since they targethematological abnormalities.
https://journal.waocp.org/article_62653_e3dd6cc0e45f8f29c0594e9ea6464ce7.pdf
Lichen Planus
oral
Diagnosis Hepatitis Therapeutics Vitamins
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1169
1173
10.22034/APJCP.2018.19.5.1169
60727
Effectiveness of Platinum-Based Treatment for Triple Negative Metastatic Breast Cancer: a Meta-Analysis
Vildan Kaya
vildansimsir@yahoo.com
1
Mustafa Yildirim
mustafayildirim7@yahoo.com
2
Gozde Yazici
yazicig@gmail.com
3
Şeyda Gunduz
drsgunduz@gmail.com
4
Hakan Bozcuk
hbozcuk@gmail.com
5
Semra Paydaş
sepay@cu.edu.tr
6
Medstar Antalya Hospital, Department of Radiation Oncology, Antalya Education and Research Hospital, Antalya,Turkey.
Bahcesehir University School of Medicine, Department of Internal Medicine, Medical Oncology, Medicalpark Gaziantep Hospital, Gaziantep, Turkey.
Hacettepe University, Department of Radiation Oncology, Ankara, Turkey.
Department of Medical Oncology, Antalya Education and Research Hospital, Antalya,Turkey.
Department of Medical Oncology, Antalya Education and Research Hospital, Antalya,Turkey.
Department of Medical Oncology, Antalya Education and Research Hospital, Antalya,Turkey.
Background: Triple-negative breast cancer (TNBC) is a sub-group of breast cancers with a particularly poorprognosis. The results of studies investigating the role of platinum-based chemotherapy (PBC) in metastatic TNBC(mTNBC) have been conflicting. In this meta-analysis, our aim was to assess the effectiveness of PBCs for mTNBCs.Methods: The PubMed, Cochrane Controlled Trials Register Databases, and EBSCOhost databases were accessed.The English language was used as the search language and only human studies were included. The Newcastle–OttawaQuality Assessment Scale and the Jadad scoring system were used to evaluate the quality of the included randomizedcontrolled studies. Results: Seven studies and 1,571 patients were included in this meta-analysis. The pooled hazardratio (HR) for overall survival (OS), evaluated on the basis of six studies, showed the use of PBC regimes to be relatedto OS in mTNBCs (HR 0.620; 95% CI 0.513-0.749; p:<0.001). Four studies containing HR and abstract statisticsused for HR calculation were included in the meta-analysis for progression-free survival (PFS). The pooled HR againindicated a significant relation (HR, 0.628; 95% CI, 0.501-0.786; p:<0.001). Conclusions: In this meta-analysis, weconfirmed that PBC regimes provide OS and PFS advantages compared to non-PBC regimes. The use of PBC regimescould be a good choice in mTNBC patients for better quality of life and survival.
https://journal.waocp.org/article_60727_ef22b8b2c9f6b40f9a643f689a3fb571.pdf
Triple-negative breast cancer
Metastasis
Chemotherapy
platinum
Prognosis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1175
1180
10.22034/APJCP.2018.19.5.1175
62694
Epidemiology of HPV Infection and HPV-Related Cancers in Kazakhstan: a Review
Gulzhanat Aimagambetova
gulzhanat.aimagambetova@nu.edu.kz
1
Azliyati Azizan
azliyati.azizan@nu.edu.kz
2
Department of Biomedical Sciences, Nazarbayev University School of MedicineKazakhstan.
Department of Biomedical Sciences, Nazarbayev University School of MedicineKazakhstan.
Background: Cancer is one of the most prevalent causes of mortality worldwide. In the cervix it is considered to becaused by different high-risk human papillomavirus (HPV) types. Although many studies have already been conductedworldwide on the epidemiology of HPV infection and their oncogenic properties, limited data are available on HPVprevalence, incidence and genotype specific dissemination in Kazakhstan. Methods: To review the distribution of HPVinfection, electronic databases (e.g. PubMed, Web of Science and Google Scholar) were searched for peer reviewedarticles in English. The study was performed during June-July 2017 with a review of 39 relevant articles, published upto July 31, 2017. The following inclusion criteria were applied: general population data, cytology results available, anduse of polymerase chain reaction (PCR) and/or Hybrid Capture® 2, Digene Corp., USA for HPV detection. Results:As reported in limited studies, the prevalence of HPV infection in Kazakhstan ranges from 43.8% to 55.8%. However,the scenario with regard to epidemiology of HPV related cancers in Kazakhstan is not very clear. One study reported adecline of laryngeal cancer observed during the recent years, whereas cervical cancer incidence has increased to about3000 new cervical cancer cases, and about 1,000 cervical cancer deaths each year. Conclusion: The high incidenceof cervical cancer with a significant mortality rate in Kazakhstan is evidence of HPV infection abundance despite anabsence of HPV screening and low public awareness of the problem. Having a well-informed understanding of the roleof HPV infection could enhance the public’s acceptance of screening and intervention programs to reduce morbidityand mortality in the country due to HPV infection. Thus, the purpose of this review article is to summarize the existingdata, identifying directions for future research on HPV epidemiology and HPV-related diseases in Kazakhstan.
https://journal.waocp.org/article_62694_e93a38d57d99018e4ea6df3e8e83d1c0.pdf
Keywords: Human papillomavirus
Cervical cancer
HPV epidemiology
HPV-related cancers
Kazakhstan
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1181
1184
10.22034/APJCP.2018.19.5.1181
60678
Clinical Response to CHOP vs. R-CHOP in Adult Patients with Diffuse Large B-Cell Lymphomas
Ayesha Tariq
ayeshatariq592@gmail.com
1
Muhammad Tahir Aziz
tahir@skm.org.pk
2
Yasir Mehmood
3
Shehroz Ali Asghar
4
Azhar Khurshid
dr.ak1515@yahoo.com
5
University of Central Punjab, Lahore, Pakistan.
Department of Pharmacy, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
Department of Pharmacy, Government College University Faisalabad, Lahore, Pakistan.
Basic Health Unit Mureedky, Lahore, Pakistan.
Department of Pharmacy, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
Purpose: The purpose of this study was to address the question of “superiority of R-CHOP versus CHOP”, withaddition of Rituximab to CHOP, regarding survival of patients suffering from DLBCL. Patients and methods: A cohortretrospective design was used to conduct this study in a tertiary care hospital. A total of 100 patients (50 in each group)were randomly selected. The primary and secondary end points were EFS, OS, PFS and DFS. Kaplan Meier survivalcurve analysis (log rank, Breslow and Tarone ware tests) was employed to compare probability of survival for the twogroups (CHOP/ R-CHOP). Results: The mean primary and secondary clinical indicators were estimated for each group(EFS, 1.7; 3.09 with a p value P=0.02), (OS, 0.60; 0.43 with a p value P=0.40), (PFS, 1.73; 3.57 with a p value P=0.002), (DFS, 0.02; 0.48 with a p value of P=0.00). Conclusion:The results for differences in clinical response were statistically significant in favor of the R-CHOP group.
https://journal.waocp.org/article_60678_cbc6144ea30ca946dac773031ce96323.pdf
Keywords: CHOP
RCHOP
clinical response evaluation
DLBCL
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1185
1188
10.22034/APJCP.2018.19.5.1185
60717
Significant Pattern of Promoter Hypermethylation of UNC5C Gene in Colorectal Cancer and Its Implication in Late Stage Disease
Sartaj A Guroo
drsartajguroo@gmail.com
1
Ajaz A Malik
ajazamalik@yahoo.com
2
Dil Afroze
afrozedil@gmail.com
3
Shazia Ali
w.shazia@gmail.com
4
Arshad A Pandith
arshaajiz@gmail.com
5
Adfar Yusuf
adfaryusuf@gmail.com
6
Department of General And Minimal Invasive Surgery, Sher-I-Kashmir Institute of Medical Sciences (SKIMS) Srinagar, Kashmir, India.
Department of General And Minimal Invasive Surgery, Sher-I-Kashmir Institute of Medical Sciences (SKIMS) Srinagar, Kashmir, India.
Department of Immunology and Molecular Medicine, SKIMS, India.
Advanced Centre for Human Genetics, SKIMS, India.
Advanced Centre for Human Genetics, SKIMS, India.
Department of Immunology and Molecular Medicine, SKIMS, India.
Background:The development of Colorectal Cancer (CRC) is a complex multistep process involving an accumulationof multiple genetic and epigenetic alterations. Epigenetic modifications, particularly DNA methylation in selectedgene are recognized as common molecular alterations in human tumors. Netrin-1 receptors are aberrantly methylatedin primary colorectal cancer. Epigenetic alterations in the netrin-1 receptors have been found to be related with themalignant potential of CRC. Purpose: In the present study, we evaluated the role of promoter hypermethylationof UNC5C gene (one of the netrin-1 receptors) in colorectal cancer patients of Kashmiri population (North India).Hypermethylation in tumour tissue was detected by Methylation- Specific Polymerase Chain Reaction (MS-PCR).Results: UNC5C promoter hypermethylation was significantly found to be associated with colorectal cancer caseswhere frequency was 62% (31 of 50) and 38% (19 of 50) patients were unmethylated (p<0.0001).UNC5C methylationwas significantly higher in CRCs with a frequency of 62% than 10% in corresponding normal mucosa of (p<0.0001).Further, UNC5C hypermethylation was found to be significantly associated with stage-III/IV as compared to stage I/IIwith a frequency of 75.8% and 42.8% respectively(p>0.05). Conclusion: We conclude that UNC5C hypermethylationis implicated in CRC which plays a role in its tumorigenesis and may predict the late stage disease.
https://journal.waocp.org/article_60717_33cddcf5b74427fe10f85f85eb1bcf90.pdf
colorectal cancer
hypermethylation
UNC5C
Netrin-1
DCC
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1189
1193
10.22034/APJCP.2018.19.5.1189
62642
Surgeons’ Recommendation is the Factor in Determining the Breast Cancer Surgery Procedures: an Experience from Rural Hospital in Thailand
Ajaree Sattaratnamai
ja.ajaree@gmail.com
1
Noppawat Samankatiwat
noppawat98@yahoo.com
2
Visnu Lohsiriwat
a.sattaratnamai@gmail.com
3
Depatment of Surgery, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Ratchaburi Hospital, Department of Surgery, Ratchaburi, Thailand.
Division of Head-Neck and Breast Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand.
Introduction: The majority of breast cancer patients in rural hospital in developing countries still warrant for totalmastectomy. Surgeon advice regard surgical procedure is one of the most important factors in decision making. Ourstudy aims to compare the rate of breast-conserving surgery (BCS), mastectomy (MT) and mastectomy with immediatebreast reconstruction (MTIBR) between the surgeons who offer only MT (group A) and who offer BCS MT and MTIBR(group B). Method: A retrospective cohort study was conducted at Ratchaburi hospital, Thailand from January 2010to April 2014. We categorized patients into 2 groups (group A and B). Univariated analysis was selected to determinethe factors that associated with the breast surgery procedures. Results: From January 2010 to April 2014, we recruited310 breast cancer patients, 221 patients (71.2%) were treated by surgeons in group A, 89 patients (28.7%) by surgeonsin group B. The choice of breast surgery is significantly different between 2 groups (P<0.001). In group A, 213 (96.3%)patient had MT and only 3 (1.3%) BCS and 5 (2.2%) MTIBR. Whilst in group B, 58 (65.1%) patient had MT and11 (12.3%) BCS and 20(22.4%) MTIBR. Choice of breast surgery in patients with stage 1,2,3 are significantly differentbetween 2 groups (P=0.004, <0.001, 0.025 respectively). Age is the only factor that significantly affects the choiceof surgery in the group B but not in group A. Conclusion: Surgeon’s competency and comprehensive preoperativeconsultation by offering BCS, MT and MTIBR can affect the choice of surgical procedure for breast cancer patient.
https://journal.waocp.org/article_62642_9a41f443a4898054cd523c428346f0aa.pdf
breast conserving surgery
breast reconstruction
breast surgery
mastectomy
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1195
1199
10.22034/APJCP.2018.19.5.1195
62634
Study Protocol: Prospective Study of Concurrent Chemoradiotherapy with S-1 and Hypofractionated Radiotherapy for Outpatients with Early Glottic Squamous Cell Carcinomas
Kana Kimura
nishicherry@med.nagoya-u.ac.jp
1
Yoshiyuki Itoh
itoh@med.nagoya-u.ac.jp
2
Tohru Okada
tohruokada@med.nagoya-u.ac.jp
3
Seiji Kubota
sjkubota@med.nagoya-u.ac.jp
4
Mariko Kawamura
mkawamura@med.nagoya-u.ac.jp
5
Rie Nakahara
rie-naka@kvp.biglobe.ne.jp
6
Yumi Oie
yumi-oie@med.nagoya-u.ac.jp
7
Yuka Kozai
yukas57@med.nagoya-u.ac.jp
8
Yuuki Takase
takase.yuuki@med.nagoya-u.ac.jp
9
Hidenori Tsuzuki
tdk27@med.nagoya-u.ac.jp
10
Naoki Nishio
naokin@med.nagoya-u.ac.jp
11
Mariko Hiramatsu
ma.7.ri.6.ko@gmail.com
12
Yasushi Fujimoto
yasushif@med.nagoya-u.ac.jp
13
Takefumi Mizutani
t-mizu0834@med.nagoya-u.ac.jp
14
Akihiro Hirakawa
hirakawa@med.nagoya-u.ac.jp
15
Sinji Naganawa
naganawa@med.nagoya-u.ac.jp
16
Department of Radiology, Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Shouwa-ku, Nagoya 4668550, Aichi, Japan.
Department of Radiology, Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Shouwa-ku, Nagoya 4668550, Aichi, Japan.
Department of Radiology, Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Shouwa-ku, Nagoya 4668550, Aichi, Japan.
Department of Radiology, Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Shouwa-ku, Nagoya 4668550, Aichi, Japan.
Department of Radiology, Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Shouwa-ku, Nagoya 4668550, Aichi, Japan.
Department of Radiology, Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Shouwa-ku, Nagoya 4668550, Aichi, Japan.
Department of Radiology, Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Shouwa-ku, Nagoya 4668550, Aichi, Japan.
Department of Radiology, Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Shouwa-ku, Nagoya 4668550, Aichi, Japan.
Department of Radiology, Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Shouwa-ku, Nagoya 4668550, Aichi, Japan.
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Shouwa-ku, Nagoya, Aichi 466-8550, Japan.
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Shouwa-ku, Nagoya, Aichi 466-8550, Japan.
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Shouwa-ku, Nagoya, Aichi 466-8550, Japan.
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Shouwa-ku, Nagoya, Aichi 466-8550, Japan.
Department of Clinical Oncology and Chemotherapy, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Shouwa-ku, Nagoya, Aichi 466-8550, Japan.
Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Shouwa-ku, Nagoya, Aichi 466-8550, Japan.
Department of Radiology, Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Shouwa-ku, Nagoya 4668550, Aichi, Japan.
Background: The recommended treatment strategies for early glottic carcinoma with intent of larynx preservation areprimarily radiotherapy. However, the outcomes of radiotherapy for bulky T1 or T2 glottic carcinoma are unsatisfactory.We designed a protocol consisting of concurrent chemoradiotherapy using S-1 as the radiosensitizer. We have performedthis protocol in patients with favorable T2 lesions and demonstrated its efficacy and safety. In contrast, we havetreated non-bulky T1 glottic carcinomas with 2.25 Gy per fraction, for a total of 25-28 fractions, starting in 2011 toimprove efficacy and shorten the treatment period. Since this treatment strategy was implemented for T1 disease, nolocal failure has occurred to date, and it appears to be almost as safe as radiotherapy using 2.0 Gy per fraction. Withthe aim of improving the local control rate and shortening the treatment period primarily for favorable T2 disease, wechanged the dose of radiation in our protocol from 2.0 Gy to 2.25 Gy per fraction, for a total of 25 fractions (from 30fractions). The present study aims to evaluate the efficacy and safety of this new protocol. Methods: This study willbe conducted as a clinical, prospective, single-armed, non-randomized trial. Patients are to receive S-1 (55.3 mg /m2/day, once daily) and radiotherapy (2.25 Gy per fraction, for a total of 25 fractions). S-1 and radiotherapy are startedon the same day that radiotherapy is performed, 3-6 hours after oral administration of S-1. The primary study aim isthe 3-year local control rate. The secondary study aims are overall survival, voice-preservation survival, disease-freesurvival, complete response rate, completion rate, and toxicity. Result and conclusion: This is the first single-center,non-randomized, prospective study of concurrent chemoradiotherapy with S-1 and hypofractionated radiotherapy tobe conducted. The trial will evaluate the efficacy and safety of our protocol.
https://journal.waocp.org/article_62634_ef031da8956553556e843cf7360eb1d7.pdf
S-1
early glottic cancer
concurrent chemoradiotherapy
prospective study
hypofractionated radiotherapy
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1201
1207
10.22034/APJCP.2018.19.5.1201
62652
Peer Leaders and Phone Prompts: Implications in the Practice of Breast Care among College Students
Paulo Maria N Pagkatipunan
adreyes0708@gmail.com
1
University of the Philippines Manila, Philippines.
Background: Compliance with breast self-examination (BSE) guidelines helps detect breast cancer early whileincreasing physical activity decreases the risk of having breast cancer. Finding ways to early initiate and maintain suchbehavior among youth is therefore important. In this study we aimed to determine the effects of two health promotioneducation interventions on knowledge and attitude to breast care, as well as practice of BSE and physical activity byfemale college students. Materials and Methods: A total of 999 students from ten colleges underwent two kinds ofhealth education strategies for three months, namely the traditional health education program (THEP) and tapping peerleaders using mobile phone prompts (PPHEP). Results: Improvement in knowledge and attitude was shown for bothgroups as compared to the control group. Both interventions equally increased the practice of BSE and maintenance ofthe recommended level of physical activity. Conclusion: There was an increase in the knowledge and positive attitudeto breast care and practice of BSE with an improvement in the level of exercise when THEP and PPHEP interventionswere used. Health education with peers using mobile phone prompts offers an alternative and effective way of promotingBSE and acceptable levels of exercise.
https://journal.waocp.org/article_62652_95ddd215424891fb04b9a1f0c6a4084e.pdf
breast cancer
Breast self-examination
breast cancer knowledge
mobile phone prompts, peer health educators
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1209
1214
10.22034/APJCP.2018.19.5.1209
62643
Lack of Impact of Race Alone on Cervical Cancer Survival in Brazil
Angelica Nogueira-Rodrigues
angelica.onco@uol.com.br
1
Andreia Cristina de Melo
andreia.melo@inca.gov.br
2
Flávia Vieira Guerra Alves
falves@inca.gov.br
3
Mariana do Nascimento Vilaça
marianavilaca@yahoo.com.br
4
Laisa Gabrielle Silva
laisasilva1504@yahoo.com.br
5
Cristiane Alves Silva
ga.cristiane@yahoo.com.br
6
Juliana Chaves Fabrini
jufabrini@gmail.com
7
Anderson Thiago Vieira Carneiro
a.thiagocarneiro@gmail.com
8
Luiz Claudio Santos Thuler
lthuler@gmail.com
9
Faculdade de Medicina da UFMG. Belo Horizonte, Minas Gerais, Brazil.
Divisão de Ensaios Clínicos e Desenvolvimento de Fármacos, Instituto Nacional de Câncer (INCA). Rio de Janeiro, Rio de Janeiro, Brazil.
Departamento de pesquisa clínica do Instituto Nacional de Câncer (INCA), Rio de Janeiro, Rio de Janeiro, Brazil.
Faculdade de Medicina da Universidade de Itaúna. Itaúna, Minas Gerais, Brazil.
Faculdade de Medicina da Universidade de Itaúna. Itaúna, Minas Gerais, Brazil.
Faculdade de Medicina da Universidade de Itaúna. Itaúna, Minas Gerais, Brazil.
Faculdade de Medicina da Universidade de Itaúna. Itaúna, Minas Gerais, Brazil.
Faculdade de Medicina da Universidade de Itaúna. Itaúna, Minas Gerais, Brazil.
Divisão de Ensaios Clínicos e Desenvolvimento de Fármacos, Instituto Nacional de Câncer (INCA). Rio de Janeiro, Rio de Janeiro, Brazil.
Objective: To analyze differences in survival between black and non-black women diagnosed with cervical cancerand treated at the National Cancer Institute in Brazil. Methods: This retrospective cohort study was conducted usingmedical records of patients who were treated for cervical cancer between 2006 and 2009 at the Brazilian National CancerInstitute - Rio de Janeiro - Brazil. The clinical and epidemiological characteristics of black and non-black patients werecompared using the chi-square test. Survival functions over five years were calculated using the Kaplan-Meier estimatorand compared using the log-rank test. Associations between race and mortality risk were analyzed using the Coxproportional hazards model. P-values women, of whom 188 (12.7%) were black, 1,209 (81.6%) were non-black and 85 (5.7%) were of unspecified race.The age at diagnosis of the patients ranged from 19 to 84 years (mean 50.1 years; SD±13.2). Hemoglobin at the time of diagnosis (p=0.008) and absence of surgery as primary treatment (p = 0.005) were more frequentamong black women. Cox analysis adjusted for these two factors showed no statistically significant difference in themortality risk associated with cervical cancer among black and non-black women (HR=1.1 95% CI 0.9-1.5; p=0.27).Conclusion: After adjusting for hemoglobin levels and surgery, race alone was not shown to be a prognostic factorfor patients with cervical cancer.
https://journal.waocp.org/article_62643_5d384102e02a592e15430e909e1c817b.pdf
Cervical Neoplasms
Race or Ethnicity
Prognosis
Brazil
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1215
1221
10.22034/APJCP.2018.19.5.1215
62623
Association between Dietary Inflammatory Index (DII) and Risk of Breast Cancer: a Case-Control Study
Farhad Vahid
farhdvahid@outlook.com
1
Nitin Shivappa
shivappa@email.sc.edu
2
Mahshid Hatami
mahshid.hatami@yahoo.com
3
Mahya Sadeghi
mahya_sadeghi88@yahoo.com
4
Fatemeh Ameri
fameri76@yahoo.com
5
Yasaman Jamshidi-Naeini
jamshidinaeini@yahoo.com
6
James R Hebert
jhebert@sc.edu
7
Sayed Hossein Davoodi
hdavoodi1345@gmail.com
8
Department of Nutritional Sciences, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USA.
Department of Nutritional Sciences, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Nutritional Sciences, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Nutritional Sciences, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Nutritional Sciences, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USA.
Department of Nutritional Sciences, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Breast cancer (BrCa) is the most common cancer among women worldwide and is the secondleading cause of cancer-related death in women, in developed countries. This cancer is among the top five mostcommon cancers in Iran. Studies have shown that dietary components are implicated in the etiology of BrCa. Theexistence of molecular connections between inflammation and BrCa has been demonstrated via different bimolecularevents. Methods: We examined the ability of the dietary inflammatory index (DIITM) to predict the risk of BrCa.This included 145 cases and 148 controls, who attended the specialized centers. DII scores were computed basedon dietary intake assessed using a 168-item FFQ. Logistic regression models were used to estimate multivariableORs. Results: Modeling DII as a continuous variable in relation to risk of BrCa showed a positive association afteradjustment for age and energy (OR=1.76; 95% CI=1.43-2.18); and were nearly identical in the multivariable analyses(OR=1.80; 95% CI=1.42-2.28). DII as tertiles, and adjusting for age and energy, subjects in tertile 3 had an OR of 6.94(95% CI= 3.26-14.79; P-trend ≤0.0001) in comparison to subjects in tertile 1. After multivariable adjustment, resultswere essentially identical as in the model adjusting for age and energy (OR tertile 3vs1=7.24; 95% CI=3.14-16.68;P-trend ≤0.001). Sub group analyses revealed similar positive associations with HER 2 receptor +ve, progesteronereceptor +ve, estrogen receptor +ve and lymph node invasive cases. Conclusion: Subjects who consumed a morepro-inflammatory diet were at increased risk of BrCa compared to those who consumed a more anti-inflammatory diet.
https://journal.waocp.org/article_62623_0a59408d777520127abe1e42a1a1de05.pdf
breast cancer
Inflammation
Dietary Inflammatory Index (DII)
Nutritional Assessment
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1223
1227
10.22034/APJCP.2018.19.5.1223
62677
O6-Methyguanine-DNA Methyl Transferase (MGMT) Promoter Methylation in Serum DNA of Iranian Patients with Colorectal Cancer
Mahvash Alizadeh Naini
malizadenaini@yahoo.com
1
Soudabeh Kavousipour
sodabe_k13@yahoo.com
2
Maryam Hasanzarini
mokaram2@yahoo.com
3
Amir Nasrollah
saeedeh_saeb@yahoo.com
4
Ahmad Monabati
suny.respina@gmail.com
5
Pooneh Mokarram
mokaram2@gmail.com
6
Gastroenterohepatology Research Center, Nemazi Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Biotechnology, School of Advanced Medical Science and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pathology, School of Medicine, Shiraz University of Medical sciences, Shiraz, Iran.
Colorectal Research Center, Nemazi hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Introduction: Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide but current molecular targetedtherapy is not providing major success in CRC treatment, so early detection by non-invasive methods continues tobe vital. Aberrant methylation of CpG islands in promoter regions is associated with inactivation of various tumorsuppressor genes. O6-methyguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that removes mutagenicand cytotoxic adducts from O6-guanine in DNA. Aberrant hypermethylation of the MGMT promoter has beenassociated with lack of mRNA expression, with concomitant loss of protein content and enzyme activity. AIM: Ouraim was to determine whether MGMT promoter methylation might be detectable in circulating free DNA in the serumof CRC patients and normal individuals using a methylation specific (MSP) polymerase chain reaction (PCR) method.Methods: A total of 70 subjects were enrolled in the study. Of these, 30 patients who were diagnosed previously asuntreated colon adenocarcinoma by a gastroenterologist and the other 40 were nearly age-matched individuals who hada normal colonoscopic evaluation (except for hemorrhoids or fissures) and normal pathologic reports. After bisulphitemodification of DNA, serum samples were examined for MGMT promoter methylation using MSP. Results: Ninetypercent of CRC patients had MGMT promoter hypermethylation as compared to no methylation in normal subjects’serum. Most of the cancers were stage П and moderately differentiated adenocarcinomas; nearly 60% were found inthe left colon. No statistically significant correlation was found between the promoter methylation status and genderand age. Discussion and Conclusions: MGMT hypermethylation can be detected in free circulating DNA in serum ofCRC patients and can be used “as a clinical biomarker” for early diagnosis and prognostic assessment of the disease.Our data confirm previous studies indicating utility for free circulating DNA as a serum biomarker for early detection,diagnosis and monitoring of CRC patients.
https://journal.waocp.org/article_62677_08ce232436f2c4a1e87aa2af21e250fe.pdf
MGMT
colorectal cancer
promoter methylation
Iranian patients
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1229
1236
10.22034/APJCP.2018.19.5.1229
62650
Impact of Double Expression of C-MYC/BCL2 Protein and Cell of Origin Subtypes on the Outcome among Patients with Diffuse Large B-Cell Lymphoma: a Single Asian Center Experience
Ching Soon Teoh
csteoh20@yahoo.com
1
Soo Yin Lee
2
Su Kien Chiang
3
Teng Keat Chew
4
Ai Sim Goh
5
Haematology Unit, Department of Internal Medicine, Hospital Pulau Pinang, Penang, Malaysia.
Department of Pathology, Hospital Pulau Pinang, Penang, Malaysia.
Haematology Unit, Department of Internal Medicine, Hospital Pulau Pinang, Penang, Malaysia.
Haematology Unit, Department of Internal Medicine, Hospital Pulau Pinang, Penang, Malaysia.
Haematology Unit, Department of Internal Medicine, Hospital Pulau Pinang, Penang, Malaysia.
Background: Diffuse large B-cell lymphoma (DLBCL) with double expression of c-MYC and BCL2 protein isassociated with dismal outcome after treatment with R-CHOP. Local data on disease burden and survival outcome inDLBCL is limited. We investigated the prognostic values of c-MYC/BCL2 protein co-expression and cell of originsubtypes using immunohistochemistry (IHC) and to determine their associations with multiethnic groups underresource limited setting. Methods: This was a retrospective study which recruited 104 patients in between June 2012and December 2015 for IHC review and analysis. Result: We demonstrated that patients with high InternationalPrognostic Index (IPI) (score 3-5) and co-expression of c-MYC/BCL2 protein had significant inferior overall survival(OS) and event free survival (EFS) respectively (P<0.05). c-MYC/BCL2 protein co-expression was more common innon-germinal center B-cell (non-GCB) (P=0.048) and contributed to adverse prognosis in this group of patients (OS,P=0.004; EFS, P=0.005). In multivariate analysis, double-protein co-expression was a significant independent predictorof inferior outcome after adjusted for IPI and cell of origin subtypes (OS hazard ratio [HR], 2.11; 95% CI, 1.01 to 4.04;P=0.048; EFS HR, 2.31; 95% CI, 1.05 to 5.04; P=0.036). In addition, non-GCB subtype was more common than GCBin Malays (60% vs 40%, P=0.106) and Chinese (81.2% vs 18.8%, P=0.042). Indians had more DLBCL without c-MYC/BCL2 protein co-expression compared to double-protein positive cases (66.7% vs 33.3%, P=0.414). Otherwise, theprognostic impact of ethnicity on survival outcome was insignificant (P=0.961). Conclusion: c-MYC/BCL2 proteinco-expression in non-GCB subtype constituted a unique group with extremely inferior outcome regardless of ethnicity.Gene expression profile (GEP) may possibly provide insights into the cause of discrepancies in DLBCL subtypes andprotein expression among the multiethnic groups.
https://journal.waocp.org/article_62650_a52a694e8d7186b8aa9f5ddc018ee9ef.pdf
Asian
DLBCL
c-MYC and BCL2 protein co-expression
GCB
non-GCB
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1237
1242
10.22034/APJCP.2018.19.5.1237
60604
Reversal of Multidrug Resistance in an Epirubicin-Resistant Gastric Cancer Cell Subline
Aledson Vitor Felipe
aledson.felipe@gmail.com
1
Juliana de Oliveira
juliana@uni9.pro.br
2
Andrea Aparecida Moraes
amoraes29a@gmail.com
3
Jerônimo Pereira de França
jeronimopf@gmail.com
4
Tiago Donizetti da Silva
tsilva.tds@gmail.com
5
Nora Manoukian Forones
noraforones@gmail.com
6
Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, Brazil.
Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, Brazil.
Department of Biological Sciences, Estadual University of Santa Cruz, Bahia, Brazil.
Department of Biological Sciences, Estadual University of Santa Cruz, Bahia, Brazil.
Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, Brazil.
Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, Brazil.
Background: Gastric cancer is one of the most common malignancies worldwide. Epirubicin (EPI) is usedextensively in the treatment of multiple cancers despite its tendency to induce multidrug resistance though overexpressionof the ABCB1 efflux pump. However, this overexpression can be disrupted using short interfering RNAs (siRNAs).Objective and Methods: The aim of this study was to explore approaches to reverse EPI resistance and thus increasethe success of chemotherapy treatment in an EPI-resistant gastric cancer cell subline (AGS/EPI). Methods: The studyfocused on effects of ABCB1 knockdown by siRNA technology using TaqMan gene expression assays with quantitativereal-time reverse-transcription PCR (qRT-PCR). MTT assays were performed to evaluate viability and prolifer in subline.ABCB1 protein localization and EPI intracellular fluorescence intensity in AGS/EPI cells were detected by confocalmicroscopy. Results: The siRNA efficiently downregulated ABCB1 mRNA in AGS/EPI cells. Thus MDR reversalwas clearly demonstrated in the AGS/EPI cells, offering the possibility of future in vitro chemoresistance assays forthe GC field. Conclusions: ABCB1 knockdown decreased EPI efflux and increased EPI sensitivity in AGS/EPI cells.This result provides a novel strategy for targeted gene therapy to reverse EPI resistance in gastric cancer.
https://journal.waocp.org/article_60604_758823a08a51c70c924b09b1f167fef9.pdf
RNA interference
Gastric cancer
ABCB1
Drug resistance
epirubicin
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1243
1249
10.22034/APJCP.2018.19.5.1243
60605
Curcumin for the Prevention of Epithelial-Mesenchymal Transition in Endoxifen-Treated MCF-7 Breast Cancer Cells
P Paramita
paramitapmm@gmail.com
1
Bantari WK Wardhani
bantariwisynu@gmail.com
2
Septelia Inawati Wanandi
septelia@gmail.com
3
Melva Louisa
melva.louisa@gmail.com
4
Master program in Biomedical Sciences, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Doctoral program in Biomedical Sciences, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Background: Curcumin was shown to reduce epithelial-mesenchymal transition (EMT) markers in previous shortterm studies. This study was aimed to investigate the potential of curcumin in the prevention of EMT activation inMCF-7 cells induced by endoxifen. Methods: MCF-7 breast cancer cells were treated with Endoxifen 1000 nM+betaestradiol1 nM with or without curcumin (8.5μM or 17 μM). Cells treated with dimethyl sulfoxide (DMSO) 0.001%were used as negative control. After 8 weeks of continuous treatment, the cells were counted, analyzed for mRNAE-cadherin, vimentin, TGF-β expression, total reactive oxygen species (ROS) and observed for morphological changesusing confocal microscope and transmission electron microscope. Result: MCF-7 cell viability was increased inendoxifen + β-estradiol group. Cell viability was significantly decreased in curcumin 17 μM, but not in curcumin8.5 μM group. Analysis of EMT markers at week 8 indicates that there were increase in vimentin and TGF-β mRNAexpressions, while E-cadherin mRNA expressions and TGF-β1 protein concentrations were shown to decrease. Theresults showed that administration of curcumin in all the dose administered were incapable improving the expressionsof vimentin, TGF-β1 and E-cadherin. There was a decrease in ROS concentration in curcumin treated cells (8.5 μM)while in curcumin 17 μM, ROS concentration was increased. Morphological observation using confocal microscopeand TEM showed the presence of mesenchymal cells and adherens junction. Conclusion: endoxifen treatments foreight weeks resulted in upregulation of EMT markers and changes in morphology of MCF-7 breast cancer cells. Theaddition of curcumin did not prevent the activation of EMT.
https://journal.waocp.org/article_60605_8ce72b09c40d320ec1bfc4adc8aa0ae4.pdf
curcumin
endoxifen
epithelial-mesenchymal transition (EMT)
Vimentin
TGF-β1
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1251
1257
10.22034/APJCP.2018.19.5.1251
60718
Implementation of Medication Safety Practice in Childhood Acute Lymphoblastic Leukemia Treatment
Sri Mulatsih
smulat@gmail.com
1
Iwan Prahasto
iwandwi@indo.net.id
2
- Sutaryo
sutaryo@indosat.net.id
3
Department of Pediatrics, Faculty of Medicine, Universitas Gadjah Mada/ Dr. Sardjito Hospital, Yogyakarta, Indonesia.
Department of Pharmacy, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Department of Pediatrics, Faculty of Medicine, Universitas Gadjah Mada/ Dr. Sardjito Hospital, Yogyakarta, Indonesia.
Objective: Medical Safety Practice (MSP) is a safe procedure in medication process. It is important to investigatethe use of MSP among childhood cancer patients because pediatric oncology is a high-risk area for potentially harmfuladverse events. The purpose of this study is to determine the effects of the implementation of MSP in chemotherapyon the incidence of medication errors in childhood ALL patient at Dr. Sardjito Hospital, including in 1) transcribing,2) administering, 3) monitoring, 4) the incidence of adverse drugs events. (ADEs). Methods: The study design is aquasi-experimental study with pre- and post-intervention without control. The sample consists of ALL patients whoare taken care of at an academic hospital in Indonesia from 2012 to 2013. The sample was consecutively collectedduring the period of study. The data were collected through medical records, research form, observation, and discussionwith the nurse. The intervention given is training and implementation of medical safety practice in chemotherapy.Result: Based on the analysis of the effect of the implementation of MSP (75 and 106 medical records of pre- andpost-intervention), it is obtained: 1) the adherence of chemotherapy transcribing post-intervention increases significantlycompared to pre-intervention (p<0.05), 2) the adherence of chemotherapy administering increases significantly inalmost every aspect (p<0.05), except in preparing drugs by two different health worker, patient’s confirmation ofADEs management, and verification of drug’s expired date, 3) The adherence of chemotherapy monitoring improvedsignificantly post-intervention (p<0.05), 4) Adverse Drug Events (ADE) decreased significantly post-intervention(p<0.05), from 52.1% to 30.5%. Conclusion: The implementation of MSP decreased the incidence of medicationerrors in ALL patients at Dr. Sardjito Hospital in ordering, dispensing, transcribing, administering, and monitoringchemotherapy. It also reduced the incidence of ADEs related to chemotherapy. Specific training for nurses are neededin order to improve the knowledge and skills, especially for medication error and skill in patients’ care.
https://journal.waocp.org/article_60718_6d90a432466540795c8a7c3a353747a0.pdf
children ALL
standard chemotherapy
medication errors
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1259
1262
10.22034/APJCP.2018.19.5.1259
60721
Radiotherapy Enhancement with Electroporation in Human Intestinal Colon Cancer HT-29 Cells
Ali Yadollahpour
rezaee.z@ajums.ac.ir
1
Zohre Rezaee
rezaee.zohre1989@gmail.com
2
Vahid Bayati
vahid_bayati@yahoo.com
3
Mohammad Javad Tahmasebi Birgani
zohrerezayi98@yahoo.com
4
Fereshteh Negad Dehbashi
fereshteh.negad@gmai.com
5
Department of Medical Physics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Medical Physics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Medical Physics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Background: The efficiency of radiotherapy for tumors can be enhanced with different radiosensitizers. Previousstudies have shown that electroporation (EP) can sensitize some cancer cell lines to ionizing radiation (IR). HT-29is a radiation resistant colorectal cancer cell line, representative of a cancer type which is the second cause of cancermortalities in developed countries. The present study aimed to evaluate radiosensitizing effects of EP on HT-29 cellsin vitro exposed to 6 MV X-ray photon beams. Methods: HT-29 cells were exposed to a 6 MV X-ray photon beamas the control or to a combination of electroporation and irradiation. The response of cells was evaluated by colonyformation assay and survival curves. Results: The survival fraction of the HT-29 cells was significantly decreased byelectroporation prior to radiotherapy. A single electric pulse increased colorectal HT-29 cancer cell sensitivity to megavoltageradiation by a factor of 1.36. Conclusion: Our findings showed that EP before radiotherapy can significantlyenhance tumor cell sensitivity. This combined treatment modality should be assessed for its applicability in clinic settingsfor employment against radioresistant cancers. However, to facilitate achieving this goal, many different tumors witha broad range of radiosensitivities should be evaluated.
https://journal.waocp.org/article_60721_3c8406edb75b813619e0acc54afc73d4.pdf
Electroporation
Irradiation
Radiosensitizing
Colon cancer
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1263
1268
10.22034/APJCP.2018.19.5.1263
62621
The Association between Molecular Subtypes of Breast Cancer with Histological Grade and Lymph Node Metastases in Indonesian Woman
Yunita Setyawati
setya.yunita@gmail.com
1
Yeni Rahmawati
bio.yenirahmawati@gmail.com
2
Irianiwati Widodo
irianiwatiwidodo@yahoo.com
3
Ahmad Ghozali
ahmadghoz@yahoo.com
4
Dewajani Purnomosari
d.purnomosari@ugm.ac.id
5
Department of Histology and Cell Biology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Department of Histology and Cell Biology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Department of Anatomic Pathology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Department of Anatomic Pathology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Department of Histology and Cell Biology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Objective: Breast carcinoma is a heterogeneous disease which is rich in diversity. Molecular subtypes of breastcancer, histological grade and lymph node metastases are strong prognostic and predictive factors. In Indonesia,only a limited number of studies have investigated the correlation between molecular subtypes with histologicalgrade and lymph node metastases. Methods: We analyzed 247 invasive breast carcinoma cases from the AnatomicPathology Installation of Dr. Sardjito General Hospital Yogyakarta between 2012-2015. The slides were stained forestrogen receptors (ER), progesterone receptors (PR), HER2, Ki-67 and CK5/6 for classification into breast cancersubtypes (BCS). Histological grade using the Nottingham system and lymph node status were obtained from anatomicpathology records. The association between histological grade and lymph node status with BCS was examined withChi-square tests. Results: The immunohistochemical features of 247 cases of women with invasive breast carcinomawere examined. There were 102 (41.3%) patients with Luminal A, 34 (13.8%) patients with Luminal B, 48 (19.4%)patients with HER2-positive, and 63 (25.5%) patients with triple negative breast cancer (TNBC). There were 148(59.9%) patients with negative lymph node status and 99 (40.1%) with positive status. Among 63 TNBC cases, 37(58.7%) patients were positive for CK5/6 staining (basal-like). Statistically, there were significant differences betweenhistological grade and subtypes (p=0.013). However, no significant differences were found for lymph node metastases(p=0.540). Conclusion: Among subtypes, Luminal A has the highest frequency, followed by TNBC, HER2-positiveand Luminal B. Histological grade was associated with molecular subtypes of breast carcinoma in Yogyakarta. GradeI was associated with Luminal A, while Grade III was associated with Luminal B, HER2 and TNBC subtypes.
https://journal.waocp.org/article_62621_2d46a45c26062cc963a2cf6747aa051f.pdf
Breast carcinoma
molecular subtypes
histological grade
lymph node metastases
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1269
1275
10.22034/APJCP.2018.19.5.1269
62654
The Development of Quality of Life Questionnaire for Indonesian Breast Cancer Patients: INA-BCHRQoL
Agusdini Banun Saptaningsih
dini_banun_dini@yahoo.com
1
Didik Setiawan
d.didiksetiawan@gmail.com
2
Ronny Rivany
ronnie_rivany@yahoo.com
3
Teguh Aryandono
gagoek@idola.net.id
4
Jarir Atthobari
j.atthobari@gmail.com
5
Iwan Dwiprahasto
iwandwi@indo.net.id
6
Pharmacology and Therapy Department, Faculty of Medicine, University Gadjah Mada, Yogyakarta, Indonesia.
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University Muhammadiyah, Purwokerto, Indonesia.
Faculty of Health Sciences, University Indonesia, Indonesia.
Department of Surgery, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Pharmacology and Therapy Department, Faculty of Medicine, University Gadjah Mada, Yogyakarta, Indonesia.
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University Muhammadiyah, Purwokerto, Indonesia.
Introduction: The breast cancer related incidence and mortality rate in Indonesia are included in the top 10 andtop 5 highest in the world. A country-specific Health Related Quality of Life measurement tool is required to helpclinician observe and improve the management of the disease. Methods: We developed the questionnaire, namelyIndonesian Breast Cancer Health Related Quality of Life (INA-BCHRQoL) by incorporating not only the genericvariables such as physical, psychological, and social; but also spiritual variable which is suitable for Indonesianpopulation. The questionnaire was validated to the same population using the value of corrected item-total correlationand the value of Cronbach Alpha. Results: Fourty three questions were considerably valid and reliable on evaluatingthe HRQoL of early state of breast cancer patients in Indonesia as the value of Cronbach Alpha for physical, cognitive,social and spiritual domain were higher than 0.8 and the corrected item-total correlation were also higher than 0.3.Each domain of the questionnaire was not influenced by the treatment options. Twenty four early stage breast cancer(10 FAC based chemotherapy and 14 Taxan based chemotherapy) were enrolled in the main study and the score ofHRQOL obtained from INA-BCHRQoL were considerably high. Conclussion: The INA-BCHRQoL questionnairecan be implemented as a valid and reliable tool to assess quality of life in early stage breast cancer patients in Indonesia.
https://journal.waocp.org/article_62654_66d50478a4168f68ee061330f7c29c06.pdf
breast cancer
QOL
INA-BCHRQoL
Indonesia
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1277
1280
10.22034/APJCP.2018.19.5.1277
60719
Expression Level of Caspase Genes in Colorectal Cancer
Milad Asadi
miladasadi1389@gmail.com
1
Dariush Shanaehbandi
dariush_shanehbandi@yahoo.com
2
Touraj Asvadi Kermani
toraj.kerman1988@gmail.com
3
Zohreh Sanaat
zohrehsanaat@yahoo.com
4
Venus Zafari
zafari_1369@yahoo.com
5
Shahriyar Hashemzadeh
said.aslani@yahoo.com
6
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of General and Thoracic Surgery, Imam Khomeini Hospital, Tabriz, Iran.
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of General and Thoracic Surgery, Imam Khomeini Hospital, Tabriz, Iran.
Background: Caspases proteins are protease enzymes involved in the initiation and execution of apoptosis process.Regulation of apoptosis process plays an important role in the normal biological events and development. In additionto developmental abnormalities, dysregulated apoptosis system may lead to tumorigenesis, autoimmunity, and otherserious health problems. Aberrant regulation of apoptosis may also be the paramount cause of chemoresistance duringcancer therapy. It is aimed through this study to evaluate the transcript levels of Caspase 3, 8, and 9 in tumoral tissuesfrom patients with colorectal cancer (CRC) and compare it with normal marginal tissues. Methods: Fifty tumor tissuesand their matched marginal tissues, as control group, were obtained from CRC patients. Total mRNA of all tissuesamples was extracted and cDNA was synthesized. Using SYBR Green PCR master mix and Real-time gene expressiontechnique, the transcript level of target genes was quantified. Results: Experiments indicated that mRNA expressionsof caspase 9 and 3 were downregulated in tumoral tissues from CRC patients in comparison to marginal tissues. Incontrast, tumoral tissues expressed mRNA of caspase 8 higher than normal marginal tissues. Modified transcript levelsof caspase 3, 8, and 9 were correlated with the clinical manifestations of the patients. Conclusions: Alteration in themRNA level of caspase genes may be involved in the development of CRC.
https://journal.waocp.org/article_60719_bae397105331935077edc0209cc953f9.pdf
colorectal cancer
caspase
Gene expression
mRNA level
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1281
1286
10.22034/APJCP.2018.19.5.1281
62622
Predictors of Breast Cancer Screening Among Korean American Women: Is Having an Annual Checkup Critical?
Soonok An
san@ncat.edu
1
Y. Joon Choi
choiyj@uga.edu
2
Hee Yun Lee
hlee94@ua.edu
3
Young Ji Yoon
yoonx381@umn.edu
4
Melody Platt
mlbrink@uncg.edu
5
Department of Social Work and Sociology, North Carolina A&T State University, Greensboro, NC, USA.
School of Social Work, University of Georgia, Athens, GA, USA.
School of Social Work, University of Alabama, Tuscaloosa, AL, USA.
School of Social Work, University of Minnesota, St. Paul, MN, USA.
The Joint Master of Social Work Program, North Carolina A&T State University and University of North Carolina Greensboro Greensboro, NC, USA.
Objective: Korean American (KA) immigrant women underutilize breast cancer screening. This study examinedfactors predicting breast cancer screening behavior among KA women in the United States. Methods: 233 KA womenaged 19 to 85 were recruited in the metro area of Atlanta, Georgia. Andersen’s behavioral model theoretically guidedthe study. Result: Of the predisposing factors, age (OR=1.043, p<.01, 95% CI [1.017, 1.069]) and marital status(OR=2.154, p<.05, 95% CI [1.022, 4.539]) were significantly associated with clinical breast exam (CBE), while income(OR=2.289, p<.05, 95% CI [1.060, 4.945]) and annual checkup (OR=2.725, p<.01, 95% CI [1.342, 5.533]) werelinked to CBE as enabling factors. For the receipt of mammographic screening, annual checkup was only significantlyassociated among enabling factors (OR=4.509, p<.05, 95% CI [1.263, 16.102]), while family cancer history wasidentified as the only significant need factor (OR=.112, p<.01, 95% CI [.023, .552]). Conclusion: Differing factorsexplained the receipt of CBEs and mammographic use among KA women. Specifically, the findings shed light on theimportance of having an annual checkup for the uptake of both CBEs and mammographic use. Intervention strategiesshould focus on promoting health accessibility for KA women to adhere to recommended breast cancer screening.
https://journal.waocp.org/article_62622_62257157b9e2fba5bd4f01cc285fbdb9.pdf
Early Detection of Cancer
Korean American Women
Immigrants
Health Services Accessibility
mammography
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1287
1293
10.22034/APJCP.2018.19.5.1287
61496
Analysis of the Lipid Profile in Patients with Colorectal Cancer in Advanced Stages
Adiel Goes de Figueiredo Junior
adielgfigueiredo@gmail.com
1
Patrícia Valéria Pereira Serafim
pati.serafim@hotmail.com
2
Augusto Azzolini de Melo
augusto_azz@yahoo.com.br
3
Aledson Vitor Felipe
aledson.felipe@gmail.com
4
Edson Guimarães Lo Turco
edsonlt@gmail.com
5
Ismael Dale Cotrim Guerreiro da Silva
ismael.dale@gmail.com
6
Nora Manoukian Forones
noraforones@gmail.com
7
Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, Brazil.
Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, Brazil.
Department of Surgery, Urology Division, Federal University of Sao Paulo, Brazil.
Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, Brazil.
Department of Surgery, Urology Division, Federal University of Sao Paulo, Brazil.
Department of Medicine, Gynecology Division, Federal University of Sao Paulo, Brazil.
Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, Brazil.
Backgrounds: Colorectal (CRC) is one of the main cause of cancer worldwide. The search for noninvasive markersfor diagnosis and monitoring as the use of analytical technologies such as mass spectrometry (MS), which allowed thesearch for lipid metabolites as candidates for probable biomarkers are needed. Objective and Methods: The objectivewas to establish the lipid profile of patients with locally advanced, unresectable or metastatic CRC. Peripheral bloodwas collected from patients with CRC and controls with normal colonoscopy. After lipid extraction, the samples wereprocessed and analyzed in the MALDI TOF / TOF equipment. From the data matrix, the statistical analyzes wereperformed by the principal component analysis methods and the least squares discriminant analysis. The importance ofthe variable in the projection was used to identify the ions that had the greatest discriminatory effect between the groups.Results: Eight lipids were identified as potential biomarkers and a multiple logistic regression model was proposedto calculate the performance of the test where we observed values of AUC 0.87, sensitivity 88.33% and specificity83.78% and for a validation test with 1,000 permutations a p glycerophospholipids and policetidis. The strength of the association between the peak intensities of these lipids andthe presence of CRC make these metabolites candidates for possible biomarkers. The sphingolipid (m / z = 742.98869)could be a biomarker in monitoring patients with CRC. In the survival analysis, three lipids showed a prognostic valuefor colorectal cancer, sphingolipid (m / z = 857.11525) and policetidis (m / z = 876.20796) and glycerophospholipid(m / z = 1031.54773).
https://journal.waocp.org/article_61496_908c13422a36a263a928fb9290f71fa9.pdf
Lipidomic
colorectal cancer
Biomarker
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1295
1302
10.22034/APJCP.2018.19.5.1295
60802
Therapeutic Use of Metformin in Diabetes and Survival Outcomes in Endometrial Cancer Patients with Diabetes
Putsarat Insin
mamieo3020@gmail.com
1
Nisa Prueksaritanond
nisa3054@gmail.com
2
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Rajavithi Hospital, Bangkok, Thailand.
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Rajavithi Hospital, Bangkok, Thailand.
Objectives: To compare survival outcomes between endometrial cancer (EC) patients with diabetes who usedmetformin to those who did not use metformin. Materials and Methods: A retrospective cohort study was conductedof EC patients who were diabetes at the time of their cancer diagnosis and had been scheduled for elective surgeryat Rajavithi Hospital between 1 January 2003 and 31 December 2013. The patients were excluded if they had typeI diabetes mellitus and a history of other cancers. Results: Of 1,262 EC patients in the study period, there was 212(16.8%) patients who met the inclusion criteria. Among them, 90 (42.5%) were non-metformin users and 122 (57.5%)were metformin users. With a median follow-up of 47 months, the 5-year overall survivals (76.4% vs 77.9%, p=0.959)and the 5-year progression-free survivals (92.6% vs 84.7%, p=0.091) did not significantly differ between the bothgroups. On Cox proportional-hazards regression analysis, independent prognostic factors for overall survival (OS)were FIGO stage, depth of myometrial invasion, and cervical involvement. Patients with non-endometrioid histologyand advanced stage were found to have a significant effect on progression-free survival (PFS). However, metforminused did not predict either OS (HR, 0.99; 95%CI, 0.56-1.73; p=0.959) or PFS (HR, 2.19; 95%CI, 0.86-5.55; p=0.099).Conclusion: Overall, a significant effect of metformin on survival outcomes in EC patients with diabetes was not foundin the current study. Larger studies with a prospective randomized control design are needed to clarify the benefit ofmetformin as a strategy for endometrial cancer prevention and treatment.
https://journal.waocp.org/article_60802_6d01ad7e13a463465c96dfccca60ebd1.pdf
Endometrial cancer
Diabetes
Metformin
Overall survival
Progression-free survival
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1303
1311
10.22034/APJCP.2018.19.5.1303
62655
Pediatric Palliative Care in Iran: Applying Regionalization of Health Care Systems
Leila khanali Mojen
leilakhanali@yahoo.com
1
Maryam Rassouli
rassouli.m@gmail.com
2
Peyman Eshghi
peshghi64@gmail.com
3
Kazem Zendedel
kzendeh@sina.tums.ac.ir
4
Ali Akbari Sari
akbarisari@tums.ac.ir
5
majideh heravi karimooi
majdehheravi@yahoo.com
6
Mamak Tahmasebi
mamaktahma@yahoo.com
7
Azam Shirin Abadi Farahani
farahani1381@yahoo.com
8
Department of Pediatric Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Pediatric Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Hematology and Oncology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pediatric, School of Nursing and Midwifery, Shahed University, Tehran, Iran.
Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pediatric Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Establishing palliative care services is a priority in the health system of Iran. Considering the necessityof integrating these services into the health system, this study aimed to explore the stakeholders’ perceptions about theprovision of a conceptual framework for palliative care services for children with cancer according to the health systemin of Iran. Methods: The present qualitative study was conducted through in-depth semi-structured interviews heldwith 29 participants including palliative care specialists, policy-makers, health care providers, the parents of childrenwith cancer selected through purposive sampling, between August 2016 and February 2017. Interviews continueduntil saturation of data. All interviews were recorded, transcribed and analyzed using MAXQDA10 software. Results:The codes extracted from interviews produced the main theme “ classes of palliative care services” with the two maincategories “comprehensive care” including, strengthening family shelter, maintaining the child in a familiar environment,achieving stability and “establishing social justice” including, easy access to services, financial relief and quality care.Conclusion: Presenting a framework based on level of palliative care services, the findings of this study paves the wayfor integrating these services into Iranian health system.
https://journal.waocp.org/article_62655_3cc53196f94e68ad071288a99ce35aa1.pdf
palliative care
Pediatric
regionalization
health system
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1313
1318
10.22034/APJCP.2018.19.5.1313
60731
Association of Two CD44 Polymorphisms with Clinical Outcomes of Gastric Cancer Patients
Seyed Mohammadreza Bitaraf
bitaraf_mreza@yahoo.com
1
Reihaneh Alsadat Mahmoudian
rmahmoudian@yahoo.com
2
Mohammadreza Abbaszadegan
abbaszadeganmr@mums.ac.ir
3
Anahita Mohseni Meybodi
anahitamohseni@gmail.com
4
Negin Taghehchian
n_taghehchian@yahoo.com
5
Atena Mansouri
mansouria932@mums.ac.ir
6
Mohammad Mahdi Forghanifard
forghanifard@gmail.com
7
Bahram Memar
memarb@mums.ac.ir
8
Mehran Gholamin
mehran.gholamin@yahoo.com
9
Department of Cellular and Molecular Biology, University of Science and Culture, Tehran, Iran.
Immunology Research Center, Mashhad University of medical Sciences, Mashhad, Iran.
Medical Genetics Research Center, Faculty of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
Department of Radiation oncology, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Objective: CD44 is an important cell adhesion molecule that plays a key role in growth, invasion, proliferation andmetastasis of cancer cells. CD44 protein over-expression is associated with a poor prognosis of gastric cancer (GC) andprevious studies have shown that CD44 gene polymorphisms could affect survival and recurrence. In this study, wetested the hypothesis that polymorphisms impacting on the CD44 signaling pathway may predict clinical outcomes inpatients with GC. Materials and Methods: DNA was extracted from blood of 150 healthy individuals and formalin-fixedparaffin-embedded (FFPE) tumor tissue of 150 patients. The two polymorphisms rs187116 and rs7116432 werestudied by RFLP-PCR and sequencing techniques. Results: There was a strong significant correlation between singlenucleotide polymorphisms (SNPs) in the CD44 gene, tumor recurrence, and overall survival (p <0.0001). The existenceof a significant relationship between tumor recurrence and overall survival was proved in this study, with at least oneallele G for the polymorphism rs187116 and at least one allele A for polymorphism rs7116432. Conclusion: These resultsprovide evidence of a relationship between CD44 gene polymorphisms and clinical outcomes in our GC patients.This result could help identify individuals with GC who have a high risk of tumor recurrence.
https://journal.waocp.org/article_60731_d038263dd8eaa9579d48ffdad581e042.pdf
Gastric cancer
CD44 gene
Single nucleotide polymorphism
RFLP-PCR
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1319
1324
10.22034/APJCP.2018.19.5.1319
60720
Model for Prediction of Optimal Debulking of Epithelial Ovarian Cancer
Maliheh Arab
drmarab@yahoo.com
1
Farzane Jamdar
jamdar.farzane@gmail.com
2
Maryam Sadat Hosseini
hoseiny339@yahoo.com
3
Robabe Ghodssi-Ghasemabadi
r.ghodsi@modares.ac.ir
4
Farah Farzaneh
f_farzaneh@sbmu.ac.ir
5
Tahereh Ashrafganjoie
dr_ganjoei@hotmail.com
6
Cancer Research Center, ShahidBeheshti University of Medical Science, Tehran, Iran.
Preventive Gynecology Research Center (PGRC), Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.
Preventive Gynecology Research Center (PGRC), Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.
Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Preventive Gynecology Research Center (PGRC), Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.
Preventive Gynecology Research Center (PGRC), Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.
Background: Primary cytoreduction surgery followed by chemotherapy is the cornerstone treatment for epithelialovarian cancer (EOC). In patients with a low probability of optimal primary surgical debulking, neoadjuvantchemotherapy (NACT) followed by interval debulking increases the chance of optimal surgery. The aim of this studywas to develop a model to identify preoperative predictors for suboptimal cytoreduction. Methods: Medical recordsof patients with EOC who underwent primary cytoreductive surgery in a referral tertiary gyneco-oncology centerwere reviewed from 2007 to 2017. Data were collected on a range of characteristics including demographic features,comorbidities, serum tumor markers, hematologic markers, preoperative imaging, surgical procedures, and pathologicreports. Univariate and multivariate analyses were performed to clarify the ability of preoperative factors to predictsuboptimal primary surgery. Results: The majority of patients (71.3%) who underwent primary cytoreductive surgerywere optimally debulked. Based on the Youden index, the best cut-off point for the serum CA125 level to distinguishsuboptimal debulking was 420U/ml with 0.730 (95%CI:0.559 to 0.862) sensitivity and 0.783 (0.684 to 0.862) specificity.Multiple logistic regression results showed that serum CA125 level >420 U/ ml (p value <0.001), the presence of livermetastasis on preoperative imaging (p value: 0.041) and ascites (p value: 0.032) or massive ascites (p value:0.010)significantly increased the risk of suboptimal debulking (logit p = 2.36 CA125 level +1.85 Liverinvolvement +1.68presence of Ascites+ 2.28 Massive Ascites). Conclusion:The present study suggests that a serum CA125 level >420 U/ml,the presence of ascites or massive ascites and liver metastasis are strong predictors of suboptimal primary surgery incases of EOC. Based on the constructed model, with any of these 4 factors, the probability of suboptimal debulking inEOC is more than 80%.
https://journal.waocp.org/article_60720_8d1e076323dd74120b9ba045192f6cb3.pdf
Optimal Debulking
Neoadjuant Chemotherapy
CA125
Prediction Model
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1325
1330
10.22034/APJCP.2018.19.5.1325
60729
Detection of Human Papilloma Virus and Risk Factors among Patients with Head and Neck Squamous Cell Carcinoma Attending a Tertiary Referral Centre in South India
Satheesh K Bhandhary
sakubaraj@gmail.com
1
Veena Shetty
vndshetty@yahoo.co.in
2
Marina Saldanha
saldanhamarina@gmail.com
3
Priya Gatti
priyams1490@gmail.com
4
Devananda Devegowda
devanandd@jssuni.edu.in
5
Pushkal S R
pushkalbiochemystery@gmail.com
6
Avinash K Shetty
ashetty@wakehealth.edu
7
Department of Otorhinolaryngology and Head and Neck Surgery, K.S.Hegde Medical Academy, NITTE University-575018 Mangalore, Karnataka, India.
Department of Microbiology, Research Co-ordinator NUCSReM, K.S.Hegde Medical Academy, Nitte University-575018, Mangalore, Karnataka, India.
Department of Otorhinolaryngology and Head and Neck Surgery, K.S.Hegde Medical Academy, NITTE University-575018 Mangalore, Karnataka, India.
Senior Research Fellow, BRNS Project, Nitte University-575018, Mangalore, Karnataka, India.
Department of Biochemistry, Centre of Excellence in Molecular Biology and Regenerative Medicine, JSS Medical College, JSS University, Mysore, Karnataka, India.
Department of Biochemistry, Centre of Excellence in Molecular Biology and Regenerative Medicine, JSS Medical College, JSS University, Mysore, Karnataka, India.
5Associate Dean for Global Health, Wake Forest University School of Medicine, Attending Physician, Brenner Children's Hospital Winston Salem, NC, India.
Background: Head and Neck Squamous Cell Carcinomas (HNSCC) is the sixth most common cancer globally. InIndia, on an average 25-30% of all cancer cases affect the head and neck. The etiological factors associated with HNSCCare tobacco, alcohol and environmental carcinogens. However there are few cases, where there are no obvious riskfactors involved. In western counties, there are many reports of human papilloma virus (HPV) association with HNSCC.Hence, we conducted a study to determine the role of HPV infection and risk factors among patients with HNSCC.Materials and Methods: A prospective, cross-sectional study was conducted in a tertiary referral centre from January2014 to March 2016. 88 patients were enrolled in the study. Socio- demographic, behavioural data, site and subsiteinvolvement, histopathology, staging and treatment were documented. Polymerase chain reaction (PCR) was performedto detect the presence of HPV DNA using consensus primers MY 09/11 and GP5+/GP6+ and further the samples weresubjected to PCR for detecting HPV type 16 and 18. Results: The study included 88 participants with HNSCC. 57had oral and oropharyngeal squamous cell carcinoma, 11 with laryngeal malignancy and 20 involving hypopharynx.Among the participants buccal mucosa (n=22) was the most common subsite involved, majority (50%) had moderatelydifferentiated squamous cell carcinoma and 53.4% presented in stage IV. 2 (2.6%) cases were positive for HPV consensusand both were positive for HPV 16, one case each in larynx and hypopharynx. There was statistical significance in theassociation between betel nut chewing, cigarette smoking and alcohol intake as risk factors in the carcinogenesis ofHNSCC. Conclusion: In our setting in South India, HPV does not play a major role in the carcinogenesis of HNSCCbut betel nut chewing, tobacco exposure and alcohol consumption remain major risk factors for HNSCC.
https://journal.waocp.org/article_60729_3836c09ffe2885fc98812835d3dad4c7.pdf
head neck squamous cell carcinoma
risk factors
Human papilloma virus
India
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1331
1336
10.22034/APJCP.2018.19.5.1331
60730
Cervical Cancer Detection between Conventional and Liquid Based Cervical Cytology: a 6-Year Experience in Northern Bangkok Thailand
Paweena Phaliwong
p_phaliwong@yahoo.com
1
Piyawan Pariyawateekul
nootpiya@hotmail.com
2
Nathaya Khuakoonratt
ningk@ymail.com
3
Worrawan Sirichai
dr.puysirichai@gmail.com
4
Kornkarn Bhamarapravatana
drkornkarn@gmail.com
5
Komsun Suwannarurk
k_suwannarurk@yahoo.com
6
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Bhumibol Adulyadej Hospital, Bangkok, Thailand.
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Bhumibol Adulyadej Hospital, Bangkok, Thailand.
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Bhumibol Adulyadej Hospital, Bangkok, Thailand.
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Bhumibol Adulyadej Hospital, Bangkok, Thailand.
Department of Preclinical Science, Thammasat University, Pathum Thani, Thailand.
Department of Obstetrics and Gynaecology,Thammasat University, PathumThani, Thailand.
Objectives: To determine the prevalence of abnormal Papanicolaou (Pap) smear, cervical intraepithelial neoplasia(CIN) 2 or higher and cancer between conventional Pap smear (CPP) and liquid based Pap smear (LBP). Methods: Thisretrospective study was conducted at Bhumibol Adulyadej Hospital, Bangkok, Thailand between January 2011 andDecember 2016. Data was collected from medical records of participants who attended for cervical cancer screening test.Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy for detectingCIN 2 or higher were evaluated by using the most severity of histopathology reports. Results: A total of 28,564 caseswere recruited. Prevalence of abnormal Pap smear from CPP and LBP were 4.8 % (1,092/22,552) and 5.7 % (345/6,012),respectively. Percentage of unsatisfactory smears in CPP (52.3%) was higher than LBP (40.5%). From CPP and LBP,cervical cancer percentages were 0.2 and 0.1, respectively. Sensitivity, specificity, PPV, NPV and accuracy of CPP andLBP for detection cancer were 42.5 vs 26.1%, 99.9 vs 100.0%, 69.8vs 75.0%, 99.7 vs 100.0 % and 99.7 vs 99.7%,respectively. Conclusion: Prevalence of abnormal cervical cytology and cancer from CPP and LBP were 4.8/0.2and 5.7/0.1 percent, respectively. Unsatisfactory smear of LBP was less than CPP. Sensitivity, specificity, PPV, NPVand accuracy of CPP and LBP for detection CIN 2 or higher and cancer were comparable.
https://journal.waocp.org/article_60730_e6928ddf7e79654cb55e1309fb1013f5.pdf
Keywords: Cervical cancer
Papanicolaou Smear
liquid based
conventional
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1337
1341
10.22034/APJCP.2018.19.5.1337
62675
Epithelial Ovarian Cancer with Endometriosis is not Associated with Menopausal Status: a Co-Association Study at Prapokklao Hospital
Supanee Muangtan
supa_aof@hotmail.com
1
Wineeya Suknikhom
pearlwineeya@gmail.com
2
Panya Sananpanichkul
panysanan@yahoo.com
3
Kornkarn Bhamarapravatana
4
Komsun Suwannarurk
5
Department of Obstetrics and Gynecology, Prapokklao Hospital, Chanthaburi 22000, Thailand.
Department of Obstetrics and Gynecology, Prapokklao Hospital, Chanthaburi 22000, Thailand.
Department of Obstetrics and Gynecology, Prapokklao Hospital, Chanthaburi 22000, Thailand.
Department of Obstetrics and Gynecology, Prapokklao Hospital, Chanthaburi 22000, Thailand.
Department of Obstetrics and Gynecology, Prapokklao Hospital, Chanthaburi 22000, Thailand.
Objective: To determine any association between the menopausal status and epithelial ovarian cancer coexistingwith endometriosis (EOC-E). In addition, the prevalence and possible risk factors were assessed. Methods: Medicalrecords of 172 women with epithelial ovarian cancer between January 2011 and December 2016 at Prapokklao Hospitalwere reviewed and divided into two groups: EOC-E defined as the case group and without endometriosis (EOC-NE)as the control group. Results: The proportion of EOC-E was 18% (31/172). There were no significant differencesbetween the two groups in baseline clinical characteristics and presenting symptoms except for history of smokingand abnormal uterine bleeding found more often in EOC-E cases. Most EOC-E were of clear cell histological typefollowed by endometrioid and serous types (35.5, 25.8 and 22.6 %; respectively). The clear cell type was 8 timesmore likely in the EOC-E than in the EOC-NE (OR 8.0, 95% CI 2.97-21.89, p-value <0.001) group. Nulliparity andsmoking increased risk of EOC-E 2 and 7 times, respectively (OR 2.3, 95%CI 1.03-5.00, p-value 0.041 and OR 7.4,95%CI 1.18-46.63, p-value 0.032). Conclusions: EOC-E are relatively common. Abnormal uterine bleeding is the onlysignificant presenting symptom in the EOC-E as compared with the EOC-NE group. Endometriosis was a predictivefactor for clear cell and endometrioid type I EOC. Menopausal status and age were not associated with a presentationof endometriosis with EOC.
https://journal.waocp.org/article_62675_87c951310e4a97195ad211a37b2d921b.pdf
Epithelial Ovarian Cancer
Endometriosis
Abnormal uterine bleeding
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1343
1349
10.22034/APJCP.2018.19.5.1343
60722
Candidate Biomarkers for Oral Squamous Cell Carcinoma: Differential Expression of Oxidative Stress-Related Genes
Nayara Fernandes Pedro
nayarafpedro@gmail.com
1
Joice Matos Biselli
joice@ibilce.unesp.br
2
José Victor Maniglia
jvmaniglia@famero.br
3
Dalisio Neto
dalisius@gmail.com
4
Erika Cristina Pavarino
erika@famerp.br
5
Eny Maria Goloni-Bertollo
eny.goloni@famerp.br
6
Patricia Matos Biselli-Chicote
patriciabiselli@famerp.br
7
Genetics and Molecular Biology Research Unit (UPGEM), São José do Rio Preto Medical School (FAMERP), Avenida Brigadeiro Faria Lima, 5416, 15090-000, São Pedro, São José do Rio Preto, São Paulo, Brazil.
Genetics and Molecular Biology Research Unit (UPGEM), São José do Rio Preto Medical School (FAMERP), Avenida Brigadeiro Faria Lima, 5416, 15090-000, São Pedro, São José do Rio Preto, São Paulo, Brazil.
Department of Otolaryngology and Head and Neck Surgery, São José do Rio Preto Medical School (FAMERP), Avenida Brigadeiro Faria Lima, 5416, 15090-000, São Pedro, São José do Rio Preto, São Paulo, Brazil.
Department of Pathology, Hospital de Base, Avenida Brigadeiro Faria Lima, 5544, 15090-000, São Pedro, São José do Rio Preto, São Paulo, Brazil.
Genetics and Molecular Biology Research Unit (UPGEM), São José do Rio Preto Medical School (FAMERP), Avenida Brigadeiro Faria Lima, 5416, 15090-000, São Pedro, São José do Rio Preto, São Paulo, Brazil.
Genetics and Molecular Biology Research Unit (UPGEM), São José do Rio Preto Medical School (FAMERP), Avenida Brigadeiro Faria Lima, 5416, 15090-000, São Pedro, São José do Rio Preto, São Paulo, Brazil.
Genetics and Molecular Biology Research Unit (UPGEM), São José do Rio Preto Medical School (FAMERP), Avenida Brigadeiro Faria Lima, 5416, 15090-000, São Pedro, São José do Rio Preto, São Paulo, Brazil.
Background: Alteration in the biotransformation of exogenous compounds can result in production of reactiveoxygen species (ROS), which can predispose cells to malignant transformation in the head and neck. This study aimedto evaluate the expression of genes involved in antioxidant metabolism in the oral squamous cell carcinoma (OSCC).Methods: The expression of eighty-four genes was evaluated in OSCC and non-tumor tissues by quantitative real-timepolymerase chain reaction using the TaqMan Gene Expression Array. The biological mechanisms related tothe differentially expressed genes were investigated using Gene – NCBI, KEGG, UNIPROT and REACTOME databases.Results: Twenty-one genes encoding enzymes involved in antioxidant metabolism were differentially expressed inthe OSCC case. Four genes (ATOX1, PRDX4, PRNP, and SOD2) were up-regulated, and seventeen (ALOX12, CAT,CSDE1, DHCR24, DUOX1, DUOX2, EPHX2, GLRX2, GPX3, GSR, GSTZ1, MGST3, PRDX1, OXR1, OXSR1,SOD1, and SOD3) were down-regulated. We identified 14 possible novel biomarkers for OSCC. The differentiallyexpressed genes appeared related to important biological processes involved in carcinogenesis, such as inflammation,angiogenesis, apoptosis, genomic instability, invasion, survival, and cell proliferation. Conclusions: Our studyidentified novel biomarkers which might warrant further investigation regarding OSCC pathogenesis since the alteredexpression in the genes can modulate biological processes related to oxidative stress and predispose cells to malignanttransformation in the oral cavity.
https://journal.waocp.org/article_60722_16442c8fe68992a07b4416fcadd3f29a.pdf
oxidative stress
Biomarker
carcinoma squamous cell
oral cavity
carcinogens
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1351
1355
10.22034/APJCP.2018.19.5.1351
59597
Socio-Cognitive Determinants of the Mammography Screening Uptake among Iranian Women
Mehdi Mirzaei-Alavijeh
mehdimirzaeia@yahoo.com
1
Parvaneh Ghorbani
parvanehmedghorbani@yahoo.com
2
Farzad Jalilian
f_jalilian@yahoo.com
3
Department of Public Health, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Public Health, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Background: Mammography screening uptake is the most effective method in breast cancer screening. The aimof this study was to determine the determinants related to mammography screening uptake among Iranian womenbased on the theory of planned behavior. Materials and Methods: This cross-sectional study was conducted among408 women who referred to health centers in Kermanshah city, the western of Iran, during 2016. Participants filledout a self-administered questionnaire. Data were analyzed by SPSS version 21 using Pearson correlation, linear andlogistic regression statistical tests at 95% significant level. Results: The mean age of participants was 39.61 years[SD: 8.28], ranged from 30 to 60 years. Almost 13% of the participants had already mammography screening uptakeat least once. Perceived behavioral control (OR=1.229) and behavioral intention (OR=1.283) were the more influentialpredictors on mammography screening uptake. Conclusions: Based on result, it seems increase perceived behaviorcontrol toward mammography screening uptake may be usefulness in promotion of mammography screening uptakeamong Iranian women.
https://journal.waocp.org/article_59597_5c82bf1f11dae33a08179673bd6c13c3.pdf
breast cancer
cognitive
Health Psychology
Behavior Change
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1357
1362
10.22034/APJCP.2018.19.5.1357
60723
Prognostic Value of FBXO39 and ETS-1 but not BMI-1 in Iranian Colorectal Cancer Patients
Jamshid Motalebzadeh
motalebzade@gmail.com
1
Samira Shabani
shabani.s@nigeb.ac.ir
2
Saeedeh Rezayati
saeedeh.rezaati20@yahoo.com
3
Narges Shakournia
shakournia1986@gmail.com
4
Rezvan Mirzaei
mirzaeirezvan@yahoo.com
5
Bahar Mahjoubi
bahar.m2@yahoo.com
6
Kamal Hoseini
frouz2@yahoo.com
7
Frouzandeh Mahjoubi
frouz@nigeb.ac.ir
8
Department of Clinical Genetics, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.
Department of Clinical Genetics, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.
Department of Clinical Genetics, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.
Department of Clinical Genetics, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.
Colorectal Research Centre (CRRC), School of Medicine, Hazrat Rasool Hospital, Iran University of Medical Sciences and Health Care Services, Tehran, Iran.
Colorectal Research Centre (CRRC), School of Medicine, Hazrat Rasool Hospital, Iran University of Medical Sciences and Health Care Services, Tehran, Iran.
Department of Urology, School of Medicine, Hazrat Rasool Hospital, Iran University of Medical Sciences and Health Care Services, Tehran, Iran.
Department of Clinical Genetics, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.
Background: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Despite recent progress indiagnosis and treatment, it remains a major health problem and further studies are needed. We here investigated expressionprofiles of the FBXO39, ETS-1 and BMI-1 genes in CRCs to validate any possible diagnostic/prognostic significance.Material and Methods: Thirty six patients with locally advanced CRC admitted to Hazrate-Rasoul Hospital-Tehranwere enrolled. Initially the expression pattern of FBXO39, ETS-1 and BMI-1 genes were determined using RT-PCRin CRC tumor and adjacent normal tissues then real-time RT-PCR was employed to quantify BMI-1 gene expression.Results: FBXO39 expression was restricted to tumor tissues. Interestingly, expression of this gene was detected in allstage-0 tumor samples. There was a significant relation between FBXO39 gene expression and lymph node involvement.The ETS-1 gene was expressed in 66% of all tumor tissues with p-value=0.03 for increase as compared to the adjacentnormal samples. In addition, there was a significant relation between ETS-1 gene expression and tumor size and lymphnode involvement. RT-PCR demonstrated BMI-1 gene expression in both tumor and normal tissues and quantificationby real-time RT-PCR showed no association between BMI-1 levels and CRC clinicopathological features. Conclusion:Expression of FBXO39 and ETS-1 with lymph node involvement may be considered as an alarm for the occurrenceof CRC metastasis, and therfore have prognostic value while BMI-1 appears without importance.
https://journal.waocp.org/article_60723_934eb427cb583381bd1d4d3c2e5363ca.pdf
Prognostic marker
colorectal cancer
Gene expression
Biomarker
Lymph node metastasis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1363
1366
10.22034/APJCP.2018.19.5.1363
62635
Comparison of Salivary Cotinine Concentrations in Male Smokers and Smokeless Tobacco Users
Marieh Honarmand
honarmand56@yahoo.com
1
Alireza Nakhaee
alireza_nakhaee@yahoo.com
2
Mohammad Moradi
dr.moradi96@gmail.com
3
Oral and Dental Disease Research Center, Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Dentist, Dental School, Zahedan University of Medical Sciences, Zahedan, Iran.
Objective: Smoking cigarettes and smokeless tobacco are one of the causes of oral cancer. This study comparedthe salivary level of cotinine in male smokeless tobacco users and smokers. Methods: In this cross-sectional(descriptive-analytical) study, stimulated saliva samples from 30 male smokers and 30 male smokeless tobacco consumerswere collected and their cotinine contents were measured using the competitive ELISA method according the standardcurve. The data was analyzed with independent t-test and linear regression using SPSS-19, and Psignificant. Result: Among the 60 subjects with the mean age of 21.27±2.6 years, the average level of cotinine insmokers (12.32±7.5 ng/ml) had no significant difference with that of smokeless tobacco consumers (11.23±4.4 ng/ml)(p=0.49). Conclusion: Salivary levels of cotinine were not significantly different in smokeless tobacco users andcigarette smokers. In addition, increases in the number of cigarettes smoked and in pack of smokeless tobacco used,were associated with increased salivary levels of cotinine. The increase was higher in smokeless tobacco consumers.
https://journal.waocp.org/article_62635_a091f858c1b22db23392fd7ce8ca5031.pdf
Saliva
cotinine
smokeless tobacco
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1367
1373
10.22034/APJCP.2018.19.5.1367
60724
Quantitative Extra Long PCR to Detect DNA Lesions in Patients Exposed to Low Doses of Diagnostic Radiation
Kainat Khan
k4kainatkhan@gmail.com
1
Shikha Tewari
shiks01@gmail.com
2
Madhup Rastogi
drmadhup1@gmail.com
3
Gaurav Raj Agarwal
drgauravraj1@gmail.com
4
Surendra Prasad Mishra
mishrasp05@gmail.com
5
Nuzhat Husain
drsridhar.rmlims@gmail.com
6
Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
Department of Pathology, King George’s Medical University, Lucknow, India.
Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
Radiodiagnosis, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
Background: Radiation causes oxidative lesions and strand breaks in DNA of exposed cells. Extended lengthPCR is a reliable method for assessing DNA damage. Longer DNA strands with DNA damage are difficult to amplifycompared to smaller DNA strands by PCR. The present study was aimed to evaluate DNA damage caused by ionisingradiation exposure in therapeutic and diagnostic medicine. Materials and Methods: The study group comprised 50cases with low dose single exposure (LDS), low dose multiple exposure (LDM) and low dose angiography (LDA)which were compared with 25 high dose controls (HDC) and 25 controls with no exposure (NEC). Blood samples werecollected within 1 hour of radiation exposure. DNA was isolated using a kit based protocol, 50 ng aliquots of DNAwere used to amplify a long 13kbp DNA fragment of the β-actin gene by conventional PCR and band intensity wasthen quantified. Relative amplification was calculated and damage was expressed in terms of lesions per kilobase (kbp)by assuming a Poisson distribution. Result: Relative amplification was found to be 1.0, 0.87, 0.86, 0.72 and 0.69 withNEC, LDS, LDM, LDA and HDC groups, respectively. Cases undergoing angiography as well as high dose controlshad high values, compared to NEC. The lesions/kbp calculated for LDS was 0.13, for LDM 0.15, for LDA 0.32 andfor HDC 0.37 suggesting a linear increase in quantity with increasing radiation dose. Conclusion: DNA damage, evenat low doses of radiation can be assessed by quantitative extra long PCR.
https://journal.waocp.org/article_60724_cca0cab3fe3f8863752382219e24d106.pdf
DNA damage
Q-PCR
Low Dose Radiation (LDR)
DNA Lesions
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1375
1379
10.22034/APJCP.2018.19.5.1375
62657
Amelogenin is a Potential Biomarker for the Aggressiveness in Odontogenic Tumors
Safa Zakaraia
dr.safa.zakarea@gmail.com
1
Mamdouh Almohareb
dr.mamdouh.almohareb@gmail.com
2
Khaled Zaid
dr.khaled.zaid@gmail.com
3
Mazen Doumani
dr.doumani.m@outlook.com
4
Mohammad Yaman Seirawan
5
Department of Oral Histology and Pathology, Faculty of Dentistry, Damascus University, Damascus, Syria.
Department of Oral Histology and Pathology, Faculty of Dentistry, Damascus University, Damascus, Syria.
Department of Oral Histology and Pathology, Faculty of Dentistry, Al sham Private University, Damascus, Syria.
Department of Restorative Dental Science, Al Farabi Colleges, Riyadh, Saudi Arabia.
Department of Endodontology, Damascus University, Damascus, Syria.
Amelogenin (AMEL), the major structural protein of the enamel organic matrix, constitutes more than 90% of theenamel’s protein content, Aberrations of amelogenin are thought to be involved in the oncogenesis of odontogenicepithelium. The expression of amelogenin is possibly an indicator of differentiation of epithelial cells in the odontogenictumors. Aim of the study: Investigating the expression of amelogenin in some odontogenic tumors, using ananti-amelogenin polyclonal antibody, and then compare it with AMEL expression in tooth buds as control. Materialsand Methods: study sample consisted of 10 formalin-fixed, paraffin- embedded specimens of ameloblastoma,10 Keratocystic odontogenic tumors, and 10 tooth buds were conventionally stained with hematoxylin-eosin andimmunohistochemically with AMEL polyclonal antibody. Results: All of the odontogenic tumors expressed AMELin the epithelial component, Intensity of expression in ameloblastoma and Keratocystic odontogenic tumor was lower,compared with tooth buds, Statistical analysis indicated a significant differences between the tumors and tooth buds.Conclusion: Amelogenin can be used as a marker for odontogenic epithelium, and the expression of amelogenin ispossibly an indicator of epithelial cells differentiation in the odontogenic tumors, and therefore in prediction of thehistological behavior of odontogenic tumors.
https://journal.waocp.org/article_62657_6bbff0c0ff15ccad5bb18ced4ee299b9.pdf
Ameloblastoma
Keratocystic odontogenic tumor
Amelogenin
Oncogenesis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1381
1385
10.22034/APJCP.2018.19.5.1381
60606
Immuno-Histochemical Assessment of HER2NEU Expression in Gastric Adenocarcinoma in North Karnataka, India
Asmanaz saleem Nadaf
dr.asma.b@gmail.com
1
Hephzibah Rani
dr.hephzibah@gmail.com
2
Udipi Shastri Dinesh
drusdinesh@sdmmedicalcollege.org
3
Department of Pathology, SDM Medical College and Hospital, Dharwad, Karnataka, India.
Department of Pathology, SDM Medical College and Hospital, Dharwad, Karnataka, India.
Department of Pathology, SDM Medical College and Hospital, Dharwad, Karnataka, India.
Background and Objectives: Gastric cancer is the fourth most common cancer worldwide and ranks fifth in India.Surgical resection is curative in early stage gastric cancers. Most of the gastric cancers are diagnosed at an advancedstage necessitating multimodality treatment strategies. Based on the ToGA trial, the international regulatory agencieshave recently approved trastuzumab in locally advanced and metastatic gastric and gastroesophageal adenocarcinomasexpressing HER2. Since there are limited studies from India and no published data available from this part of NorthKarnataka, we undertook this study to evaluate the frequency of expression of HER2 in gastric and gastroesophagealadenocarcinomas and to correlate it with various clinicopathological variables. Methodology: The study was conductedin the Department of Pathology, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka from May 2012to January 2016. The samples included both endoscopic biopsies and gastrectomies. Histopathological slides from 70cases were reviewed. Immunohistochemical staining for HER2 was performed in all the cases and Hoffman’s gastriccancer scoring system was employed. The results of HER2 expression was correlated with various clinicopathologicalparameters. Results: HER2 positivity was seen in 16/70 cases (23%). 6 cases (8.5%) were equivocal and 48/70 cases(68.5%) were HER2 negative. HER2 positivity was more common in GEJ cancers and intestinal type of adenocarcinoma.However, it did not correlate with age, gender, grade and stage. Conclusion: HER2 positivity was noted in 23% of thecases. 23.4% of intestinal type and 21.7% of diffuse type were HER2 positive. HER2 positivity did not significantlydepend on age, gender, tumour type, grade and stage. Hence, HER2 remains as an independent biomarker and should betested in all patients of gastric cancer regardless of the clinicopathological findings for offering a personalized treatment.
https://journal.waocp.org/article_60606_afe966ec840ed1c8b5954ed749b3229b.pdf
HER2
Gastric cancer
immunohistochemistry
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1387
1395
10.22034/APJCP.2018.19.5.1387
62633
Colorectal Cancer Screening among Korean Americans in Chicago: Does It Matter Whether They had the Screening in Korea or the US?
Shin-Young Lee
shinyoung0114@gmail.com
1
Department of Nursing, Chosun University 309 Pilmun-daero, Dong-gu, Gwangju, 501-759 Republic of Korea.
Background: Colorectal cancer (CRC) is one of the most common cancers in Korean Americans (KAs) and CRCscreening can detect CRC early and may reduce the incidence of CRC by leading to removal of precancerous polyps.Many KAs in the US leave the country, primarily to travel to Korea, for health screening. The aim of this study wasto (a) assess CRC screening rates, including fecal occult blood test (FOBT), flexible sigmoidoscopy, and colonoscopyand (b) explore factors related to these tests among KAs by location of CRC screening. Methods: Descriptive andcorrelational research design with cross-sectional surveys was used with 210 KAs. Socio-demographics (age, gender,years in the US, marital status, education, employment, household income, and proficiency in spoken English),access to health care (health insurance and usual source of health care), and location of CRC screening utilization(Korea, the US, or both Korea and US) were measured and analyzed using descriptive statistics and multinominallogistic regression. Results: Out of 133 KA participants who had had lifetime CRC screening (i.e., had ever had FOBT,flexible sigmoidoscopy, or colonoscopy), 19% had visited Korea and undergone CRC screening in their lifetimes. Amongsocio-demographic factors and access to health care factors, having a usual source of health care in the US (OR=8.45)was significantly associated with having undergone lifetime CRC screening in the US. Having health insurance in theUS and having had lifetime CRC screening in the US were marginally significant (OR=2.54). Conclusion: Access tohealth care in the US is important for KAs to have CRC screening in the US. As medical tourism has been increasingglobally, the location of CRC screening utilization must be considered in research on cancer screening to determinecorrelates of CRC screening.
https://journal.waocp.org/article_62633_f628616e995bb0d201f57608beeb0820.pdf
colorectal cancer
Screening
Korean Americans
Medical tourism
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1397
1404
10.22034/APJCP.2018.19.5.1397
62646
Cetuximab or Nimotuzumab Versus Cisplatin Concurrent with Radiotherapy for Local-Regionally Advanced Nasopharyngeal Carcinoma: a Meta-analysis
Zhong Guo Liang
zhongguoliang1989@126.com
1
Guo Xiang Lin
linguoxiang9139@163.com
2
Jia Xiang Ye
yejiaxiang2013@163.com
3
Ye Li
931248837@qq.com
4
Ling Li
lilingmoon99@163.com
5
Song Qu
daisyqs2002@163.com
6
Xia Liang
liangxia216@126.com
7
Xiao Dong Zhu
zhuxdonggxmu@126.com
8
Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, 71 He Di Road, Nanning 530021, P.R. China.
Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, 71 He Di Road, Nanning 530021, P.R. China.
Department of Medical Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, 71 He Di Road, Nanning 530021, P.R. China.
Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, 71 He Di Road, Nanning 530021, P.R. China.
Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, 71 He Di Road, Nanning 530021, P.R. China.
Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, 71 He Di Road, Nanning 530021, P.R. China.
Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, 71 He Di Road, Nanning 530021, P.R. China.
Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, 71 He Di Road, Nanning 530021, P.R. China.
Background: It is unclear whether Cetuximab (CTX) or Nimotuzumab (NTZ) concurrent with radiotherapy deliversequivalent or improved results with fewer toxicities over standard cisplatin (CDDP) concurrent with radiotherapyin locally advanced nasopharyngeal carcinoma (NPC). Methods: The strategy involved searching the PubMed,Embase, Cochrane Library, China National Knowledge Internet Web, Wanfang and Chinese Biomedical databases.Controlled clinical trials that compared concurrent CTX/NTZ with radiotherapy versus CDDP with radiotherapyin local-regionally advanced NPC were included. Results: In all, 1,239 patients in six clinical trials were includedin the analysis. The hazard ratios (HRs) between the CTX/NTZ and CDDP groups were 1.01 (95% confidence interval(CI) 0.63-1.64), 1.06 (95% CI 0.50-2.25), 1.04 (95% CI 0.61-1.76), and 1.05 (95% CI 0.73-1.50) for overall survival,local-regional failure-free survival, distant metastasis failure-free survival, and disease-free survival, respectively.Significant differences were found in the incidences of grade 3-4 anaemia [Risk ratio (RR) 0.11 95% CI 0.02-0.58], grade3-4 neutropenia (RR 0.23 95% CI 0.12- 0.44), grade 3-4 thrombocytopenia (RR 0.31 95% CI 0.12- 0.79), and grade3-4 vomiting (RR 0.04 95% CI 0.00-0.29) in favour of the CTX/NTZ group. However, the patients in the CTX/NTZgroup experienced a higher incidence of grade 3-4 skin rash (RR 6.45 95% CI 3.84-10.84). Conclusions: Regardingthe efficacy and side effects, the combination of CTX / NTZ and radiotherapy may be an alterative treatment regimenof standard CDDP concurrent with radiotherapy in local-regionally advanced NPC, especially in patients who cannottolerate or who refuse chemotherapy.
https://journal.waocp.org/article_62646_b918eb97758c6eaea8c4ce88708d3f81.pdf
Nasopharyngeal neoplasms
cetuximab
Nimotuzumab
radiotherapy
Meta-analysis
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1405
1410
10.22034/APJCP.2018.19.5.1405
62658
Complex Therapy Physical alone or Associated with Strengthening Exercises in Patients with Lymphedema after Breast Cancer Treatment: a Controlled Clinical Trial
Roberta Pitta Costa Luz
roberta_pitta@hotmail.com
1
Cinira Assad Simao Haddad
cinira_fisio@hotmail.com
2
Samantha Karlla Lopes de Almeida Rizzi
samyfisio@gmail.com
3
Simone Elias
simone.elias3@gmail.com
4
Afonso Celso Pinto Nazario
nazarioafonso@hotmail.com
5
Gil Facina
gilfacina@hotmail.com
6
Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Objective: To compare a complex physical therapy (CPT) protocol alone or combined with complex physicaltherapy muscle more strength training (CPT+ST) in patients with lymphedema after breast cancer treatment regardingstrength and limb muscle volume. Methods: In this controlled clinical trial, consecutive patients treated from breastcancer from April 2014 to December 2015 were allocated in two groups, the CPT group 1 and the CPT+ST group 2,that performed CPT associated with muscle strengthening. Patients in the CPT group 1 received the routine protocol ofcare, consisting of manual lymphatic drainage (MLD), multilayer bandage compression therapy, skin care and regularexercises. Patients CPT+ST performed, 2 sets of 10 repetitions exercises at 40% of maximal voluntary contraction thefirst week, increasing to 3 sets with 10 repetitions during the second and third weeks, 3 sets with 15 repetitions, for 8weeks, 50 minutes per session, twice per week. Strength and muscle volume were analyzed. Result: In the study period,42 patients were enrolled, 22 in the CPT group 1 and 20 in the CPT+ST group 2. Only 36 completed treatment. Bothgroups showed similar increases in the range of movement in: shoulder flexion, extension, adduction, abduction andexternal rotation. Internal rotation showed less improvement in CPT+ST group 2 (p = 0,034). Strength improvementwas similar between groups. The CPT+ST group 2 seemed to have a greater volume in the upper limb when comparedto CPT group 1, but it was not possible to prove any significant difference (p = 0.555). Conclusion: There was nodifference of muscular limb volume between the two interventions. This means that strengthening exercises can beperformed by patients with lymphedema safely, without the risk of increasing upper limb volume with edema.
https://journal.waocp.org/article_62658_fccb5d43db5dadeba1fcbac943c3bee1.pdf
Keywords: Breast Neoplasms
Lymphedema
Rehabilitation
Strength training
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1411
1413
10.22034/APJCP.2018.19.5.1411
62659
Prevalence and Pattern of Antibiotic Resistant Strains of Helicobacter pylori Infection in ASEAN
Ratha-Korn Vilaichone
vilaichone@hotmail.co.th
1
Duc Trong Quach
drquachtd@gmail.com
2
Yoshio Yamaoka
yyamaoka@bcm.edu
3
Kentaro Sugano
sugano@jichi.ac.jp
4
Varocha Mahachai
vmahachai@gmail.com
5
Division of Gastroenterology, Department of Medicine, Thammasat University Hospital, Pathumthani, Thailand.
Department of Internal Medicine, University of Medicine and Pharmacy, Hochiminh, Vietnam.
Department of Medicine, Gastroenterology Section, Baylor College of Medicine and Michael E. DeBakey VA Medical Center, TX, USA.
Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, Japan.
Division of Gastroenterology, Department of Medicine, Thammasat University Hospital, Pathumthani, Thailand.
Objective: Antibiotic resistance has significantly impact on eradication rates for H. pylori infection and remainsimportant cause of treatment failure worldwide including ASEAN countries. The aim of this study was to surveythe prevalence and antibiotic resistant pattern of H. pylori infection in ASEAN. Methods: This study was a survey among26 experts from 9 ASEAN countries including Thailand, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines,Singapore and Vietnam whom attended a meeting to develop the ASEAN consensus on H. pylori management in Bangkokin November 2015. A questionnaire was sent to each member of the consensus meeting. The detail of the questionnaireincluded information about prevalence of H. pylori infection, facilities to perform H. pylori culture, molecular testingfor antibiotic resistance and antibiotic resistance rate in their countries. Results: H. pylori infection remain commonin ASEAN ranging from 20% in Malaysia, 21-54% in Thailand and 69% in Myanmar. Most of ASEAN countriescan perform H. pylori cultures and antibiotic susceptibility tests except Laos and Cambodia. In ASEAN countries,metronidazole resistant H pylori is quite common whereas amoxicillin resistance remain rare. Clarithromycin resistanceresults in a significant decrease in H. pylori eradication rate with clarithromycin-containing regimens. The prevalence ofclarithromycin resistance varies in ASEAN countries being high in Vietnam (30%) and Cambodia (43%), moderate to highin Singapore (17%) and low in Malaysia (6.8%), Philippine (2%) and Myanmar (0%). In Thailand, clarithromycinresistance tends to higher in large cities (14%) than in rural areas (~3.7%). Conclusion: ASEAN countries shoulddevelop a standard protocol for regular susceptibility testing of H. pylori so that clinicians would be better able tochoose reliably effective empiric therapies. The wide range of antibiotic resistance in ASEAN countries suggests thatthe preferred first line regimen should be depend on the local antibiotic resistance other than single recommendation.
https://journal.waocp.org/article_62659_f72aecab2206149bde27ab27149c490c.pdf
Antibiotic resistant
Helicobacter pylori
ASEAN
eng
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
2018-05-01
19
5
1415
1423
10.22034/APJCP.2018.19.5.1415
62648
Association Between NR3C1 Gene Polymorphisms and Toxicity Induced by Glucocorticoids Therapy in Saudi Children with Acute Lymphoblastic Leukemia
Refaat El-Fayoumi
refaatelfayoumi@gmail.com
1
Magda Hagras
magyhagras@yahoo.com
2
Adel Abuzenadah
aabuzenadah@kau.edu.sa
3
Waleed Bawazir
wbawazir@kau.edu.sa
4
Thoraia Shinawi
tshinawi@kau.edu.sa
5
Medical laboratory Technology Department, Faculty of Applied medical Science, King Abdulaziz University, Jeddah, Saudi Arabi.
Clinical Pharmacology Department, Faculty of Medicine, Seuz Canal University. Ismailia, Egypt.
Medical laboratory Technology Department, Faculty of Applied medical Science, King Abdulaziz University, Jeddah, Saudi Arabi.
Medical laboratory Technology Department, Faculty of Applied medical Science, King Abdulaziz University, Jeddah, Saudi Arabi.
Medical laboratory Technology Department, Faculty of Applied medical Science, King Abdulaziz University, Jeddah, Saudi Arabi.
Background: Glucocorticoids (GCs) are key hormones used for the treatment of acute lymphoblastic leukemia(ALL) in children, but their cytotoxic effects are not well defined. The aim of this study was to evaluate the associationbetween polymorphisms in NR3C1 encoding for protein involved in the GCs metabolism and its role in the developmentof ALL and the toxicity outcome, in terms of liver toxicity, glucose abnormality and infections, in ALL Saudi children.Methods: The following polymorphisms BCII rs41423247, ER22/23 EK rs6189 and rs6190 and N363S rs6195 inNR3C1 were analyzed in 70 children with ALL treated according to the ALL 2000 study protocol in comparison to60 control subjects. Treatment toxicities and their association with genotypes were evaluated according to CommonToxicity Criteria (NCI-CTC). Results: This study demonstrated that the NR3C1 did not contribute to the developmentof childhood ALL. Homozygous ER22/23EK polymorphism was not found in both ALL patients and in control groupwhereas the heterozygous polymorphism was only observed in the control group (6.66%). The toxicology data inthis study showed a significant difference between ALL patients carrying N363S polymorphism and wild type (40%and 6.51% respectively, P= 0.009) and a high-risk factor in the toxicity of glucose abnormality (OR=10.167; 1.302-79.339).BCII shows increased risk factors towards the liver toxicity (OR=2.667; 0.526-7.330) as well as the glucoseabnormality (OR=7.5; 1.039-54.116). Conclusion: This study suggested that the polymorphisms in NR3C1 were notassociated with the development of ALL in children. N363S polymorphism was sensitive to glucocorticoids and it maycontribute to the glucose abnormality for these patients.
https://journal.waocp.org/article_62648_fea20fbff15a887b97e1dedd89ccabfb.pdf
Glucocorticoids Toxicity
Acute Lymphoblastic Leukemia
Glucocorticoid Receptor Polymorphisms
SNPs