%0 Journal Article %T Different Risk Relations with Smoking for Non-small-cell lung Cancer: Comparison of TP53 and TP73 Genotypes %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2003 %\ 02/01/2003 %V 4 %N 2 %P 107-112 %! Different Risk Relations with Smoking for Non-small-cell lung Cancer: Comparison of TP53 and TP73 Genotypes %K non-small-cell lung cancer %K p53 %K P73 %K Polymorphism %K smoking %K gene-environment interaction %R %X Background: The association between TP53/TP73 gene polymorphisms and tobacco smoking was evaluated with ‍regard to risk of non-small cell lung cancer (NSCLC). Methods: A case-control study with 192 histologically confirmed ‍NSCLC cases and 241 non-cancer controls was conducted. Subjects were genotyped for TP53 Arg72Pro and TP73 ‍G4C14 to A4T14 polymorphisms by PCR-based methods. Risk and interactions were assessed as odds ratios (ORs) ‍and 95% confidence intervals (CIs). Results: The analyses according to TP53 genotypes for the risk of tobacco ‍smoking illustrated that risk with heavy smoking was much higher for subjects with the TP53 ProPro genotype ‍(OR: 16.4, 95% CI 1.77-151.7) as compared with those with TP53 ArgArg/ArgPro (3.36, 1.69-6.68). Similar analyses ‍for TP73 genotypes did not show any differences for NSCLC risk. Conclusion: A risk relation of heavy smoking for ‍the NSCLC is suggested with the TP53 but not the TP73 polymorphism. ‍ %U https://journal.waocp.org/article_24173_dd1a0ae609fc46c9a793e0f859c99ab3.pdf