%0 Journal Article %T GSTM1, GSTT1 and CYP1A1 Polymorphisms and Risk of Oral Cancer: a Case-control Study in Jakarta, Indonesia %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2009 %\ 01/01/2009 %V 10 %N 1 %P 21-26 %! GSTM1, GSTT1 and CYP1A1 Polymorphisms and Risk of Oral Cancer: a Case-control Study in Jakarta, Indonesia %K Oral cancer risk - metabolizing enzyme polymorphisms - Jakarta %K Indonesia %R %X Purpose: to investigate genetic polymorphisms in GSTM1, GSTT1 and CYP1A1 and the association withthe risk of oral cancer in the Jakarta population. Method: A total of 81 cases and 162 controls matched for ageand sex were selected from 5 hospitals in Jakarta. Sociodemographic data using questionnaires were obtainedand peripheral blood samples were collected with informed consent for PCR-RFLP assay. Conditional logisticregression analysis was performed to obtain the association between the risk of oral cancer and GSTM1, GSTT1and CYP1A1 polymorphisms. Results: GSTM1 and GSTT1 null were slightly overrepresented among cases(60.5% and 45.7% respectively) compared to controls (55.6% and 41.4% respectively), but no statisticallysignificant differences were observed. In contrast, the distribution of CYP1A1 polymorphism was higher amongcontrols compared to cases (52.5 % versus 42.4 %). The odds ratio of null GSTM1 and GSTT1 genotypes wasslightly higher compared to wild type genotypes (OR 1.19, 95% CI 0.70-2.02 and OR 1.19, 95% CI 0.72-2.05respectively). Furthermore, the presence of CYP1A1 polymorphism did not increase the risk of oral cancer (OR0.70, 95% 0.39-1.25). Conclusion: Genetic polymorphisms of GSTM1, GSTT1 and CYP1A1 may not be riskfactors for oral cancer in the Jakarta population. %U https://journal.waocp.org/article_24868_5329c00c02f08842fe7c9be71d8cd2ca.pdf