%0 Journal Article %T IGlutathione S-transferase (GSTM1 and GSTT1) Polymorphisms in Cervical Cancer in Northeastern Thailand %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2009 %\ 03/01/2009 %V 10 %N 3 %P 365-368 %! IGlutathione S-transferase (GSTM1 and GSTT1) Polymorphisms in Cervical Cancer in Northeastern Thailand %K Cervical cancer - GSTM1 %K GSTT1 - Northeastern Thailand - genetic susceptibility %R %X To evaluate the relationships between genetic polymorphisms of the GSTs (GSTM1 and GSTT1) and cervicalcancer, the null genotype of each gene was studied in squamous cell cervical cancer (SCCA) patients (n=90) andcontrols (n=94) in Northeast Thailand. The prevalence of the GSTM1-null genotype in the controls and SCCApatients was 59.6% and 60.0%, respectively, whereas those of the GSTT1-null genotype in the control andSCCA patients was 40.4% and 46.7%, respectively. Neither of the GST-null genotypes increased the risk forSCCA (p>0.05); however, the combination of the GSTM-1 and GSTT1-null genotypes showed a non-significanttrend to an increased risk for developing cervical cancer with an adjusted OR of 2.7 (95%CI=0.8-9.0, p=0.10).Genetic polymorphisms of GSTM1 and GSTT1 were not significant risk factors for cervical cancer in eithertobacco-smokers or non-smokers. A different contribution of the GST genotype to cancer risk may be attributedto a different, as yet undefined, property of the enzymes. %U https://journal.waocp.org/article_24928_b23cb25377b1a426c0e19f507ac4672e.pdf