%0 Journal Article %T Clinical Results of the Liquid-based Cervical Cytology Tool, Liqui-PREPTM, in Comparison with Conventional Smears for Detection of Squamous Cell Abnormalities %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2009 %\ 03/01/2009 %V 10 %N 3 %P 399-402 %! Clinical Results of the Liquid-based Cervical Cytology Tool, Liqui-PREPTM, in Comparison with Conventional Smears for Detection of Squamous Cell Abnormalities %K cervical cancer %K Pap smear test %K Liquid-based cytology %K Liqui-PREPTM %R %X Objective: To compare the adequacy and efficacy of the liquid-based cytology tool Liqui-PREPTM (LP) withthe conventional Papanicolaou smear (CS) test, for the screening of squamous cell abnormalities. Methods:Data for 2,000 subjects screened with CS and 4,000 different subjects screened with the LP test were compared.Results: LP showed significant decrease in the rate of unsatisfactory smears (P<0.01) and the detection rate foratypical squamous cells was significantly higher (P<0.01). The rate of low-grade squamous intraepithelial lesionwas also higher, but this did not reach statistical significance. The number of high-grade squamous intraepitheliallesions detected was increased with LP, and the histological correlation of LSIL lesions showed a higher positivepredictivevalue. The coexistence of abnormal colposcopic findings with abnormal smear results was higher forLP (P<0.004). Furthermore, high-risk HPV-DNA detection was found to be increased in atypical LP smearsthan in normal LP smears. Conclusions: The liquid-based cytology tool LP detected more squamous cell lesionsthan CS. Also it reduced the number of unsatisfactory results due to enhanced cell visualization, and improvedscreening for HPV-DNA. %U https://journal.waocp.org/article_24935_81b418226b43d1bd845b89c50232a449.pdf