%0 Journal Article %T Andrographis paniculata Downregulates ProinflammatoryCytokine Production and Augments Cell Mediated ImmuneResponse in Metastatic Tumor-Bearing Mice %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2010 %\ 03/01/2010 %V 11 %N 3 %P 723-729 %! Andrographis paniculata Downregulates ProinflammatoryCytokine Production and Augments Cell Mediated ImmuneResponse in Metastatic Tumor-Bearing Mice %K Cytokines %K Metastasis %K NK cells %K andrographolide %K cell mediated immunity %R %X Effects of Andrographis paniculata extract and its major component, andrographolide, on cell-mediatedimmune responses in metastatic tumor bearing animals were studied. NK cell mediated target cell lysis wasenhanced by the administration of Andrographis paniculata extract (45.0% cell lysis) and andrographolide(40.2% cell lysis) on the 5th day after tumor induction when compared to untreated metastatic tumor bearinganimals in which maximum target cell lysis was observed on 11th day (11.4%). Antibody dependent cell-mediatedcytotoxicity (ADCC) was also enhanced by treatment with the extract (42.0% cell lysis) and andrographolide(40.2%) in comparison with the untreated case (11.0%). Similarly, the extract (25%) and andrographolide(22%) showed higher ACC activity than the control (14%) and treatment of extract and andrographolideresulted in significant increase in serum IL-2 and TIMP-1 levels. Furthermore, the levels of proinflammatorycytokines such as IL-1β, IL-6, GM-CSF and TNF-α were effectively reduced by the administration of extractand andrographolide in metastatic tumor bearing animals. %U https://journal.waocp.org/article_25271_4fe41e554a46461e195b093415579e09.pdf