%0 Journal Article %T Efficacy and Safety of Endostar Combined with Chemotherapy in Patients with Advanced Solid Tumors %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2010 %\ 04/01/2010 %V 11 %N 4 %P 1119-1123 %! Efficacy and Safety of Endostar Combined with Chemotherapy in Patients with Advanced Solid Tumors %K Endostar %K Chemotherapy %K solid tumors %K Efficacy %K safety %R %X Purpose: Endostar® is a proteolytic fragment of collagen XVIII that has been shown to have antitumor activity, with a favorable toxicological profile. We conducted this study to investigate its efficacy and safety when combined with chemotherapy in patients with advanced solid tumors. Methods: From July 2006 to September 2008, 45 patients with histologically or cytologically confirmed solid tumors were enrolled into this study. All received Endostar at a dose of 7.5 mg/m2/day as an intravenous infusion for more than 7 days, in combination with chemotherapy. Patients were treated until tumor progression or unacceptable toxicity. Results: No treatment related death occurred in this study. Main reported toxicities included: mylosuppression (82.2%), hepatic impairment (42.2%), anorexia (20.0%), nausea (24.4%), vomiting (22.2%), diarrhea (20.0%), febrile (20.0%) and fatigue (24.4%). No complete response was observed. Two patients (2/42) had partial response, twenty-one (21/42) remained stable, and nineteen (19/42) had progressive disease. Median time to tumor progression was 3.0 months (range, 0.5-12.0). Median overall survival was 30.0 months (95% confidence interval: 20.0-40.0) and 1 year survival rate was 81.0%. Conclusion: Our study revealed that toxicity of Endostar combined with chemotherapy in the treatment of solid tumors was tolerable with moderate efficacy. %U https://journal.waocp.org/article_25336_ff9835b482fe0c2f5542a764ad368c5f.pdf