%0 Journal Article %T Influence of MDR1 Gene Codon 3435 Polymorphisms on Outcome of Platinum-based Chemotherapy for Advanced Non Small Cell Lung Cancer %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2011 %\ 09/01/2011 %V 12 %N 9 %P 2291-2294 %! Influence of MDR1 Gene Codon 3435 Polymorphisms on Outcome of Platinum-based Chemotherapy for Advanced Non Small Cell Lung Cancer %K Multi-drug resistance %K platinum %K Non Small Cell Lung Cancer %K Chemotherapy %K genetic polymorphisms %R %X Objective: To evaluate the influence of multi-drug resistance 1 (MDR1) gene codon 3435 polymorphisms on response to platinum-based chemotherapeutic regimens for advanced non small cell lung cancer (NSCLC). Methods: Responses and overall survival were evaluated in a series of patients presenting between March 1, 2005 and December 31, 2010. MDR1 gene C3435T polymorphisms were genotyped using peripheral blood with real time polymerase chain reaction (RT-PCR) and relationships between the MDR1 C3435T genetic polymorphismand response rate of chemotherapy were analyzed by SPSS 13.0. Results: Overall response to chemotherapy in the eligible 103 patients was 21.4%. Patients with C/C genotype in MDR1 codon 3435 had a significantly higher response rate (24.5%) than those for C/T(19.0%) and T/T(12.5%) (P<0.05). The overall median survival time (MST) of patients was 19 months, values with C/C, C/T and T/T genotype were 21, 15.5 and 17 months, respectively (P=0.487). Conclusion: Our research suggested that patents with the C/C genotype in MDR1 codon 3435 could be more sensitive to platinum-based chemotherapy than patients with C/T and T/T; however, no significant difference was found between overall survival and MDR1 codon 3435 genetic polymorphisms. %U https://journal.waocp.org/article_25876_f579653fb604bc394a938a7f19d970a3.pdf