%0 Journal Article %T Overexpression of Snail Accelerates Adriamycin Induction of Multidrug Resistance in Breast Cancer Cells %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2011 %\ 10/01/2011 %V 12 %N 10 %P 2575-2580 %! Overexpression of Snail Accelerates Adriamycin Induction of Multidrug Resistance in Breast Cancer Cells %K breast cancer %K Snail %K Multidrug Resistance %K P-gp %K EMT cells %R %X In addition to several molecular and morphologic changes, epithelial-mesenchymal transition (EMT) cells also show variation in sensitivity to chemotherapeutics agents. The aim of this study was to investigate whether overexpression of Snail in MCF-7 cells is associated with facilitated acquisition of P-gp mediated multidrug resistance (MDR). The results demonstrated that over-expression of Snail indeed resulted in slight enhancement of adriamycin-induced MDR in MCF-7/Snail cells without detectable increase of P-gp. However, in the longer term, MCF-7 cells overexpressing Snail were prone to be resistant to adriamycin, in this case with increased expression of P-gp. These results provide evidence that a strategy involving Snail inhibition may be a useful and promising therapeutic aspect in modulating MDR. %U https://journal.waocp.org/article_25925_7648f337ad0b57288cbdedfd37d715f6.pdf