%0 Journal Article %T Significance of Oligoclonal Bands after Stem Cell Transplantation in Multiple Myeloma Cases %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2012 %\ 04/01/2012 %V 13 %N 4 %P 1483-1486 %! Significance of Oligoclonal Bands after Stem Cell Transplantation in Multiple Myeloma Cases %K multiple myeloma %K stem cell transplantation %K oligoclonal band %K significance %R %X Objective: To determine the characteristics of oligoclonal bands that are frequently detected by serum proteinelectrophoresis (SPEP) and immunofixation electrophoresis (IFE) after stem cell transplantation. Methods: Weretrospectively analyzed 56 patients with multiple myeloma (MM) undergoing transplantation, and standardimmunofixation electrophoresis was used to identify and quantify paraproteins. Results: The median follow-upwas 35 months (range, 10-76months) and 21 patients relapsed. Twelve (25.0%) demonstrated oligoclonal bandsafter a median time 1.4 months (range, 1-3months), with a median duration of 5.8 months (range, 1-15months).The majority patients with oligoclonal bands had normal quantities of immunoglobulins and the one year eventfree survival (EFS) was 92%, even higher than for patients without OBs (P=0.002). Conclusion: Oligoclonalbands frequent develop post-transplantation in MM cases. In the vast majority of patients, they may notrepresent relapsed disease, and more likely represent a transient phenomenon representing recovery of impairedimmunoglobulin production. %U https://journal.waocp.org/article_26357_2ab66cd70543ee0ff30e40c64d61ee32.pdf