%0 Journal Article %T Bicluster and Pathway Enrichment Analysis of HCV-induced Cirrhosis and Hepatocellular Carcinoma %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2012 %\ 08/01/2012 %V 13 %N 8 %P 3741-3745 %! Bicluster and Pathway Enrichment Analysis of HCV-induced Cirrhosis and Hepatocellular Carcinoma %K Bicluster analysis %K pathway enrichment %K cirrhosis %K Hepatocellular carcinoma %R %X Background: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the mostcommon form of liver cancer. However, while it is associated frequently with hepatitis C virus (HCV) there isonly an elementary understanding of its molecular pathogenesis. Methods: To gain insight into the molecularmechanisms of HCV-induced hepatocarcinogenesis, we performed microarray analysis on 75 surgical liversamples from 48 HCV-infected patients. Results: There were 395 differentially expressed geness between cirrhoticsamples and HCC samples. Of these, 125 genes were up-regulated and 270 genes were down-regulated. Weperformed pathway enrichment analysis and screened as described previously. Conclusions: The differentiallyexpressed genes might be involved in hepatocarcinogenesis through upregulating the pathways of ECM-receptorinteraction, focal adhesion, cell adhesion molecules and other cancer-related pathways, and downregulating thepathways of “complement and coagulation cascades”. We hope our results could aid in seeking of therapeutictargets for HCV-induced hepatocellular carcinoma. %U https://journal.waocp.org/article_26695_6a74f976cad4bf6a4c747ea819512a65.pdf