%0 Journal Article %T Serum Oncofetal Fibronectin (onfFN) mRNA in Differentiated Thyroid Carcinoma (DTC): Large Overlap between Disease-Free and Metastatic Patients %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2012 %\ 08/01/2012 %V 13 %N 8 %P 4203-4208 %! Serum Oncofetal Fibronectin (onfFN) mRNA in Differentiated Thyroid Carcinoma (DTC): Large Overlap between Disease-Free and Metastatic Patients %K Oncofetal fibronectin %K mRNA %K Real-Time RT-PCR %K Differentiated thyroid carcinoma %K Metastasis %R %X Aim: This study assessed if onfFN mRNA in the peripheral blood of patients with DTC can identify individualswith metastatic disease. Methods: Comparison of onfFN mRNA was made among 3 groups: disease-free, lymphnode metastasis, and distant metastasis using real-time RT-PCR on 5 ml blood samples from each DTC patient.Results: Fifty-one patients were included: 30 (59%) were disease-free; 7 (13.7%) had lymph node metastasis; and14 (27.5%) had distant metastasis. OnfFN mRNA levels in the 3 groups were significantly different (P=0.001)but with a large overlap and the expression being highest in the disease-free group. Subgroup analysis of themetastatic groups did not show any effect of age, cell type, and serum TSH, Tg, and antiTg on onfFN mRNA.The within-run and between-run root mean square coefficients of variations were <2%. Conclusion: OnfFNmRNA in patients with DTC cannot identify those with metastatic disease. %U https://journal.waocp.org/article_26697_4b9976dd25b5d01156f057f572fadb58.pdf