%0 Journal Article %T Knockdown of Bcl-3 Inhibits Cell Growth and Induces DNA Damage in HTLV-1-infected Cells) %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2013 %\ 01/01/2013 %V 14 %N 1 %P 405-408 %! Knockdown of Bcl-3 Inhibits Cell Growth and Induces DNA Damage in HTLV-1-infected Cells) %K Bcl-3 %K HTLV-1 %K DNA damage %K NF-κB activation %R %X Oncoprotein Bcl-3 is perceived as an unusual member of IκB family since it can both stimulate and suppressNF-κB activation. Aberrant Bcl-3 results in increased cell proliferation and survival, suggesting a contributionto malignant potential and elevated levels of Bcl-3 have been observed in many HTLV-1-infected T cell lines andATL cells. To investigate the specific roles of Bcl-3 in HTLV-1-infected cells, we knocked down Bcl-3 expressionusing shRNA and then examined the consequences with regard to DNA damage and cell proliferation, as wellas NF-κB activation. The HTLV-1 encoded protein Tax promotes Bcl-3 expression and nuclear translocation.In HTLV-1-infected cells, Bcl-3 knockdown obviously induced DNA damage. Cell growth and NF-κB activationwere reduced in HTLV-1-infected or Tax positive cells when Bcl-3 expression was decreased. Together, our resultsrevealed positive roles of Bcl-3 in DNA stabilization, growth and NF-κB activation in HTLV-1-infected cells. %U https://journal.waocp.org/article_26711_e5cb98ad8d4dd56c956d8934d4d826e4.pdf