%0 Journal Article %T Transmembrane Protein 166 Expression in Esophageal Squamous Cell Carcinoma in Xinjiang, China %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2012 %\ 08/01/2012 %V 13 %N 8 %P 3713-3716 %! Transmembrane Protein 166 Expression in Esophageal Squamous Cell Carcinoma in Xinjiang, China %K Esophageal squamous cell carcinoma %K transmembrane protein166 %K Apoptosis %K Autophagy %K RT-PCR %R %X Objective: Transmembrane protein 166 (TMEM166) expression in esophageal squamous cell carcinoma(ESCC) and remote normal esophageal tissues was examined to assess any role in tumour biology. Methods:TMEM166 mRNA expression in 36 cases with ESCC (36 tumour samples, 36 remote normal esophageal tissuesamples) was detected by RT-PCR. TMEM166 protein expression was analysed in paraffin-embedded tissuesamples from the same cases by immunohistochemistry. Results: Semi-quantitative analysis showed TMEM166mRNA expression in ESCCs to be significantly lower than in remote normal esophageal tissues (0.759±0.713 vs.2.622±1.690, P=0.014). TMEM166 protein expression was also significantly reduced (69.4% vs. 94.4%, P<0.01).Conclusion: TMEM166 mRNA and protein expression demonstrated significant reduction in ESCCs comparedwith remote esophageal tissues, albeit with no correlation with tumour size, differentiation, stage, and lymphnode metastasis, suggesting a role in regulating autophagic and apoptotic processes in the ESCC. %U https://journal.waocp.org/article_26748_5fe06aa257e63485bd7f08920ecf1b49.pdf