%0 Journal Article %T Curcumin Inhibits Human Non-small Cell Lung Cancer A549 Cell Proliferation Through Regulation of Bcl-2/Bax and Cytochrome C %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2013 %\ 08/01/2013 %V 14 %N 8 %P 4599-4602 %! Curcumin Inhibits Human Non-small Cell Lung Cancer A549 Cell Proliferation Through Regulation of Bcl-2/Bax and Cytochrome C %K curcumin %K Bcl-2 %K Bax %K cytochrome C %K Apoptosis %K NSCLC cells %R %X We intended to study the mechanism of the inhibitory action of curcumin on human non-small cell lung cancerA549 cell. The cell growth was determined by CCK-8 assay, and the results indicated that curcumin inhibitedthe cell proliferation in a concentration dependent manner. And to further confirm the relative anti-cancermechanism of curcumin, RT-PCR was carried out to analysis the expression of relative apoptotic proteins Bax,Bcl-2. We found that curcumin could up-regulate the expression of Bax but down-regulate the expression ofBcl-2 in A549 cells. In addition, curcumin affect the mitochondrial apoptosis pathway. These results suggestedthat curcumin inhibited cancer cell growth through the regulation of Bcl-2/Bax and affect the mitochondrialapoptosis pathway. %U https://journal.waocp.org/article_27996_e2bfe3a65d6c53fe31c6d7ee347e4be3.pdf