%0 Journal Article %T Elevated Serum IL-17A but not IL-6 in Glioma Versus Meningioma and Schwannoma %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2013 %\ 09/01/2013 %V 14 %N 9 %P 5225-5230 %! Elevated Serum IL-17A but not IL-6 in Glioma Versus Meningioma and Schwannoma %K Glioma %K meningioma %K schwannoma %K IL-17A %K IL-6 %K Serum %R %X Background: There is a Th1/Th2 cytokine imbalance and expression of IL-17 in patients with brain tumours.We aimed to compare the levels of IL-17A and IL-6 in sera of glioma, meningioma and schwannoma patientsas well as in healthy individuals. Materials and Methods: IL-17A and IL-6 levels were measured in sera of 38glioma, 24 meningioma and 18 schwannoma patients for comparison with 26 healthy controls by commercialELISA assays. Results: We observed an increase in the IL-17A in 30% of glioma patients while only 4% and5.5% of meningioma and schwannoma patients and none of the healthy controls showed elevated IL-17A in theirsera (0.29±0.54, 0.03±0.15 and 0.16±0.68 vs. 0.00±0.00pg/ml; p=0.01, p=0.01 and p=0.001, respectively). Therewas also a significant decrease in the level of IL-6 in glioma patients compared to healthy controls (2.34±4.35 vs.4.67±4.32pg/ml; p=0.01). There was a direct correlation between the level of IL-17A and age in glioma patients(p=0.005). Glioma patients over 30 years of age had higher IL-17A and lower IL-6 in their sera compared tothe young patients. In addition, a non-significant grade-specific inverse trend between IL-17A and IL-6 wasobserved in glioma patients, where high-grade gliomas had higher IL-17A and lower IL-6. Conclusions: Ourdata suggest a Th17 mediated inflammatory response in the pathogenesis of glioma. Moreover, tuning of IL-6and IL-17A inflammatory cytokines occurs during progression of glioma. IL-17A may be a potential biomarkerand/or immunotherapeutic target in glioma cases. %U https://journal.waocp.org/article_28103_8bb2f73a686d53f4aa9a2d42f96c0cfb.pdf