%0 Journal Article %T Expression of Nuclear Factor Kappa B (NF-κB) as a Predictor of Poor Pathologic Response to Chemotherapy in Patients with Locally Advanced Breast Cancer %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2014 %\ 02/01/2014 %V 15 %N 2 %P 595-598 %! Expression of Nuclear Factor Kappa B (NF-κB) as a Predictor of Poor Pathologic Response to Chemotherapy in Patients with Locally Advanced Breast Cancer %K locally advanced breast cancer %K NF-κB %K pathological response %K Neoadjuvant chemotherapy %R %X Background: NF-κB inhibits apoptosis through induction of antiapoptotic proteins and suppression ofproapoptotic genes. Various chemotherapy agents induce NF-κB translocation and target gene activation. Weconducted the present study to assess the predictive value of NF-κB regarding pathologic responses after receivingneoadjuvant chemotherapy. Materials and Methods: We enrolled 131 patients with locally advanced invasiveductal breast carcinoma. Immunohistochemistry (IHC) was used to detect NF-κB expression. Evaluation ofpathologic response was elaborated with the Ribero classification. Results: Expression of NF-κB was significantlyassociated with poor pathological response (p=0.02). From the multivariate analysis, it was found that the positiveexpression of NF-κB yielded RR=1.74 (95%CI 0.77 to 3.94). Conclusions: NF-κB can be used as a predictor ofpoor pathological response after neoadjuvant chemotherapy. %U https://journal.waocp.org/article_28630_348ac50145166ee0e96cd019c090e4cc.pdf