%0 Journal Article %T Ethanolic Extract from Derris scandens Benth Mediates Radiosensitzation via Two Distinct Modes of Cell Death in Human Colon Cancer HT-29 Cells %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2014 %\ 04/01/2014 %V 15 %N 4 %P 1871-1877 %! Ethanolic Extract from Derris scandens Benth Mediates Radiosensitzation via Two Distinct Modes of Cell Death in Human Colon Cancer HT-29 Cells %K radiosensitizer %K Derris scandens benth %K radiotherapy %K apotosis mitotic catastrophe %R %X Enhancing of radioresponsiveness of tumors by using radiosensitizers is a promising approach to increase theefficacy of radiation therapy. Recently, the ethanolic extract of the medicinal plant, Derris scandens Benth hasbeen identified as a potent radiosensitizer of human colon cancer HT29 cells. However, cell death mechanismsunderlying radiosensitization activity of D scandens extract have not been identified. Here, we show that treatmentof HT-29 cells with D scandens extract in combination with gamma irradiation synergistically sensitizes HT-29cells to cell lethality by apoptosis and mitotic catastrophe. Furthermore, the extract was found to decrease Erk1/2activation. These findings suggest that D scandens extract mediates radiosensitization via at least two distinctmodes of cell death and silences pro-survival signaling in HT-29 cells. %U https://journal.waocp.org/article_28844_b7a0aa7f5bd35750dde1d5f24c2eee59.pdf