%0 Journal Article %T Glutathione-S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Acute Leukemia Risk in Asians: a Meta-analysis %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2014 %\ 05/01/2014 %V 15 %N 5 %P 2075-2081 %! Glutathione-S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Acute Leukemia Risk in Asians: a Meta-analysis %K Acute leukemia %K Glutathione-S-transferase %K GST %K Polymorphism %K Meta-analysis %R %X The association between glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1) and riskof acute leukemia in Asians remains controversial. This study was therefore designed to evaluate the preciseassociation in 23 studies identified by a search of PubMed and several other databases, up to December 2013.Using random or fixed effects models odds ratios (ORs) with corresponding 95% confidence intervals (CIs) werecalculated. Heterogeneity across studies was assessed, and funnel plots were constructed to test for publicationbias. The meta-analysis showed positive associations between GST polymorphisms (GSTM1 and GSTT1 butnot GSTP1) and acute leukemia risk [(OR=1.47, 95% CI 1.18-1.83); (OR=1.32, 95% CI 1.07-1.62); (OR=1.01,95% CI 0.84-1.23), respectively] and heterogeneity between the studies. The results suggested that the GSTM1null genotype and GSTT1null genotype, but not the GSTP1 polymorphism, might be a potential risk factors foracute leukemia. Further well-designed studies are needed to confirm our findings. %U https://journal.waocp.org/article_28879_22eb4dd3f2d3d361306ba656c71a2c40.pdf