%0 Journal Article %T SLC35B2 Expression is Associated with a Poor Prognosis of Invasive Ductal Breast Carcinoma %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2014 %\ 12/01/2014 %V 15 %N 15 %P 6065-6070 %! SLC35B2 Expression is Associated with a Poor Prognosis of Invasive Ductal Breast Carcinoma %K Invasive ductal breast carcinoma %K poor prognosis %K SLC35B2 %R %X Background: Breast cancer is the most common malignancy in women worldwide, including Thailand, and is a major cause of mortality and morbidity, despite advances in diagnosis and treatment. Novel gene expression in breast cancer is a focus in searches for prognostic biomarkers and new therapeutic targets. Materials and Methods: The mRNA expression of novel B4GALT4, SLC35B2, and WDHD1 genes in breast cancer were examined in invasive ductal breast carcinoma (IDC) patients using quantitative real-time reverse transcriptionpolymerase chain reaction (QRT-PCR). Results: Among these genes, increased expression of SLC35B2 mRNA was significantly associated with TNM stage III + IV of IDC (p<0.001). Hence, up-regulation of SLC35B2 may serve as a prognostic biomarker for poor prognosis, and is also a potential therapeutic target in breast cancer. %U https://journal.waocp.org/article_29558_31ae0662b55311aae0b66d38134d7faa.pdf