%0 Journal Article %T Screening of Precancerous Gastric Lesions by Serum Pepsinogen, Gastrin-17, Anti-Helicobacter Pylori and Anti-Caga Antibodies in Dyspeptic Patients over 50 years Old in Guilan Province, North of Iran %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2014 %\ 12/01/2014 %V 15 %N 18 %P 7635-7638 %! Screening of Precancerous Gastric Lesions by Serum Pepsinogen, Gastrin-17, Anti-Helicobacter Pylori and Anti-Caga Antibodies in Dyspeptic Patients over 50 years Old in Guilan Province, North of Iran %K pepsinogen I %K gastrin-17 %K Helicobacter pylori antibodies %K precancerous gastric lesion %R %X Background: The aim of this study was to investigate the value of serum gastric markers to differentiatebetween patients with precancerous lesions and nonatrophic chronic gastritis. Materials and Methods: Serumsamples of 128 patients with dyspepsia who were candidates for endoscopic examination were tested forpepsinogen (PG I and PG II), PG I/II ratio, gastrin 17(G-17), anti-Helicobacter pylori (anti-H pylori ) and anti-CagA antibodies. Two sample t-tests, chi-square tests and Pearson’s correlation analyses were used for analysisusing SPSS (version 20). Results: PGI, PG I/II ratio values were decreased significantly in the precancerouslesion group (0.05, 0.001 respectively). The frequency of H pylori infection was significantly (p=0.03) differentbetween the two groups ofthe study. Conclusions: We suggest PGI and the PG I/II ratio as valuable markersfor screening of premalignant gastric lesions. %U https://journal.waocp.org/article_29814_a9d2f56557ea13e8e5e1d87f88a6205b.pdf