%0 Journal Article %T Association of Adiponectin Receptor (Adipo-R1/-R2) Expression and Colorectal Cancer %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2014 %\ 12/01/2014 %V 15 %N 21 %P 9385-9390 %! Association of Adiponectin Receptor (Adipo-R1/-R2) Expression and Colorectal Cancer %K Adiponectin receptor %K Adipo-R1/-R2 %K Colorectal carcinoma %K Prognosis %R %X Introduction: Human adiponectin (ApN) is a 30 kDa glycoprotein of 244-amino acids which is extensivelyproduced by adipocytes. ApN acts via two receptors, namely adiponectin receptor-1 (Adipo-R1) andadiponectin receptor-2 (Adipo-R2). Studies have shown the presence of Adipo-R1 and Adipo-R2 expressionimmunohistochemically in human colorectal cancers (CRCs). However, only a few studies exist which investigatedeffects of adiponectin receptor expression on CRC characteristics. Objectives: In the present study, we aimedto explore Adipo-R1/-R2 expression in human colorectal cancers and any association with clinicopathologicalcharacteristics and survival. Materials and Methods: The study enrolled 58 colorectal cancer patients with tumorresection and a control group of 30 subjects with normal colon mucosa. Results: Positivity for Adipo-R1/-R2expression was significantly more common in the control group in comparison to the patient group (both p<0.001).There was no significant association between Adipo-R1/-R2 expression and clinicopathological characteristicsincluding age, sex tumor location, pTNM stage, Duke’s stage, metastasis, histological differentiation, perineuralinvasion, venous invasion sex, lymphatic invasion, cancer-related mortality, tumor size and recurrence. Adipo-R1/-R2 positivity was also not significantly linked to progression-free or overall survival [p values (0.871, 0.758) and (0.274, 0.232), respectively]. Conclusions: Although significantly reduced Adipo-R1/-R2 expression wasfound in colorectal cancer patients, it had no influence on survival. %U https://journal.waocp.org/article_30087_761044c743737eced09ef2442197b970.pdf