%0 Journal Article %T Ifosfamide-containing Regimens for Treating Patients with Osteosarcomas %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2014 %\ 12/01/2014 %V 15 %N 22 %P 9763-9766 %! Ifosfamide-containing Regimens for Treating Patients with Osteosarcomas %K ifosfamide %K osteosarcoma %K Toxicity %K Adverse effects %K response rate %R %X Background: This systemic analysis was conducted to evaluate the efficacy and safety of an ifosfamidecontainingregimen in treating patients with osteosarcoma. Methods: Clinical studies evaluating the efficacy andsafety of Ifosfamide-containing regimen on response and safety for patients with osteosarcoma were identifiedby using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: Whenifosfamide-containing regimens were evaluated, 4 clinical studies which including 134 patients with osteosarcomawere considered eligible for inclusion. Systemic analysis suggested that, in all patients, pooled RR was 44.8%(60/134) in ifosfamide-containing regimens. Major adverse effects were neutropenia, leukopenia, and fatigueinIfosfamide-containing regimens; No treatment related death occurred in cantharidin combined regimens.Conclusion: This systemic analysis suggests that ifosfamide-containing regimens are associated with goodresponse rate and acceptable toxicity in treating patients with osteosarcoma, but this result should be confirmedby randomized clinical trials. %U https://journal.waocp.org/article_30174_a479a43fb8c0036c8d209695ca8c2afe.pdf