%0 Journal Article %T Aberrant Expression of Pim-3 Promotes Proliferation and Migration of Ovarian Cancer Cells %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2015 %\ 08/01/2015 %V 16 %N 8 %P 3325-3331 %! Aberrant Expression of Pim-3 Promotes Proliferation and Migration of Ovarian Cancer Cells %K Pim-3 %K MACC1 %K Expression %K Tumorigenesis %K Ovarian Cancer %R %X Pim kinase-3(Pim-3), a member of serine/threonine protein kinases, has been implicated in multiple humancancers and involved in Myc-induced tumorigenesis. However, little is known regarding its expression andbiological function in human ovarian cancer. In this study we showed that the clinical significance and biologicalfunctions of Pim-3 in ovarian cancer and found that higher Pim-3 mRNA level are detected in ovarian cancertissues than those in normal ovarian tissues. There are significant correlations between higher Pim-3 expressionlevels with the FIGO stage, histopathological subtypes, and distant metastasis in ovarian cancer patients.Lentivirus-mediated gene overexpression of Pim-3 significantly promotes the proliferation and migration ofSKOV3 cell lines. Furthermore, MACC1 and Pim-3 expression were significantly correlated in human ovariancancer cells, and overexpression of Pim-3 in ovary cancer cells increased MACC1 mRNA and protein expression.The data indicate that Pim-3 acts as a putative oncogene in ovary cancer and could be a viable diagnostic andtherapeutic target for ovarian cancer. %U https://journal.waocp.org/article_30914_ed63bc85bf710bb921d4e68e1cd9f70e.pdf