%0 Journal Article %T In Silico Interaction and Docking Studies Indicate a New Mechanism for PML Dysfunction in Gastric Cancer and Suggest Imatinib as a Drug to Restore Function %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2015 %\ 12/01/2015 %V 16 %N 12 %P 5005-5006 %! In Silico Interaction and Docking Studies Indicate a New Mechanism for PML Dysfunction in Gastric Cancer and Suggest Imatinib as a Drug to Restore Function %K PML %K Cag A %K Helicobacter pylori %K casein kinase %K imatinib %K docking study %R %X Gastric cancer as one of the most common cancers worldwide has various genetic and environmental riskfactors including Helicobacter pylori (H.pylori) infection. Recently, loss of a tumor suppressor gene namedpromyelocytic leukemia (PML) has been identified in gastric cancer. However, no mutation has been found in thisgene in gastric cancer samples. Cag A H.pylori protein has been shown to exert post transcriptional regulationof some tumor suppressor genes. In order to assess such a mechanism for PML degradation, we performed insilico analyses to establish any interaction between PML and Cag A proteins. In silico interaction and dockingstudies showed that these two proteins may have stable interactions. In addition, we showed that imatinib kinaseinhibitor can restore PML function by inhibition of casein kinase 2. %U https://journal.waocp.org/article_31202_16078c44a95f06f4ce04909725b096fc.pdf