%0 Journal Article %T Meningeal Hemangiopericytomas and Meningomas: a Comparative Immunohistochemical and Genetic Study %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2015 %\ 12/01/2015 %V 16 %N 16 %P 6871-6876 %! Meningeal Hemangiopericytomas and Meningomas: a Comparative Immunohistochemical and Genetic Study %K Meningeal hemangiopericytoma %K immunohistochemistry %K NAB2-STAT6 fusion %K Molecular analysis %R %X Background: The meningeal hemangiopericytoma (MHPC) is a vascular tumor arising from pericytes. Mostintracranial MHPCs resemble meningiomas (MNGs) in their clinical presentation and histological featuresand may therefore be misdiagnosed, despite important differences in prognosis. Materials and Methods:We report 8 cases of MHPC and 5 cases of MNG collected from 2007 to 2011 from the Neuro-Surgery andHistopathology departments. All 13 samples were re reviewed by two independent pathologists and investigated byimmunohistochemistry (IHC) using mesenchymal, epithelial and neuro-glial markers. Additionally, we screenedall tumors for a large panel of chromosomal alterations using multiplex ligation probe amplification (MLPA).Presence of the NAB2-STAT6 fusion gene was inferred by immunohistochemical staining for STAT6. Results:Compared with MNG, MHPCs showed strong VIM (100% of cases), CD99 (62%), bcl-2 (87%), and p16 (75%)staining but only focal positivity with EMA (33%) and NSE (37%). The p21 antibody was positive in 62% ofMHPC and less than 1% in all MNGs. MLPA data did not distinguish HPC from MNG, with PTEN loss andERBB2 gain found in both. By contrast, STAT6 nuclear staining was observed in 3 MHPC cases and was absentfrom MNG. Conclusions: MNG and MHPC comprise a spectrum of tumors that cannot be easily differentiatedbased on histopathology. The presence of STAT6 nuclear positivity may however be a useful diagnostic marker. %U https://journal.waocp.org/article_31513_908589567d08e3c16c08958abd7e1d03.pdf