%0 Journal Article %T Clinical, Histopathological and Molecular Characteristics of Metastatic Breast Cancer in North-Eastern Kazakhstan: a 10 Year Retrospective Study %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Abiltayeva, Aizhan %A Moore, Malcolm Anthony %A Myssayev, Ayan %A Adylkhanov, Tasbolat %A Baissalbayeva, Ainur %A Zhabagin, Kuantkan %A Beysebayev, Eldar %D 2016 %\ 10/01/2016 %V 17 %N 10 %P 4797-4802 %! Clinical, Histopathological and Molecular Characteristics of Metastatic Breast Cancer in North-Eastern Kazakhstan: a 10 Year Retrospective Study %K breast cancer %K molecular subtypes %K - mortality %K Metastasis %K North-East Kazakhstan %R 10.22034/APJCP.2016.17.10.4797 %X AbstractBackground: Breast cancer (BC) is the top cancer among women worldwide and has been the most frequentmalignancy among Kazakhstan women over the past few decades. Information on clinical and histopathologicalfeatures of metastatic breast cancer (MBC), as well as the distribution of molecular subtypes is limited for Kazakhpeople. Materials and Methods: The present observational retrospective study was carried out at RegionalOncologic Dispensaries in the North-East Region of Kazakhstan (in Semey and Pavlodar cities). Сlinical andhistopathological data were obtained for a total of 570 MBC patients in the 10 year period from 2004-2013, forwhom data on molecular subtype were available for 253. Data from hospital charts were entered into SPSS 20for analysis by one-way ANOVA analysis of associations of different variables with 1-5 year survival. Pearsoncorrelation and linear regression models were used to examine the relation between parameters with a p-value< 0.05 considered statistically significant. Results: No significant relationships were evident between molecularsubtype and survival, site of metastases, stage or ethnicity. Young females below the age of 44 were slightly morelikely to have triple negative lesions. While the ductal type greatly predomonated, luminal A and B cases had ahigher percentage with lobular morphology. Conclusions: In this select group of metastatice brease cancer, nolinks were noted for survival with molecular subtype, in contrast to much of the literature. %U https://journal.waocp.org/article_41217_8b223b2230acc4a0bc5d379a73462ecc.pdf