%0 Journal Article %T Mathematical Modeling of E6-p53 interactions in Cervical Cancer %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Khattak, Faryal %A Haseeb, Muhammad %A Fazal, Sahar %A Bhatti, AI %A Ullah, Mukhtar %D 2017 %\ 04/01/2017 %V 18 %N 4 %P 1057-1061 %! Mathematical Modeling of E6-p53 interactions in Cervical Cancer %K cervical cancer %K E6 %K p53 %K small molecule drug %K RITA and Mathematical modeling %R 10.22034/APJCP.2017.18.4.1057 %X Background: Cervical cancer is the third most common cancer in women throughout the world. The humanpapillomavirus (HPV) E6 viral protein plays an essential role in proteasomal degradation of the cancer suppressantprotein p53. As a result, p53 negative regulation and apoptosis relevant activities are abrogated, facilitating developmentof cervical cancer. Methods: A mathematical model of E6-p53 interactions was developed using mathematical laws. Insilicosimulations were carried out on CellDesigner and as a test case the small molecule drug RITA was considered forits ability to rescue the functions of tumor suppressor p53 by inhibiting E6 mediated proteasomal degradation. Results:Using a computational model we scrutinized how p53 responds to RITA, and chemical reactions of this small moleculedrug were incorporated to perceive the full effects. The evolved strategy allowed the p53 response and rescue of itstumor suppressor function to be delineated, RITA being found to block p53 interactions with E6 associated proteins.Conclusion: We could develop a model of E6-p53 interactions with incorporation of actions of the small moleculedrug RITA. Suppression of E6 associated proteins by RITA induces accumulation of tumor suppressant p53. UsingCellDesigner to encode the model ensured that it can be easily modified and extended as more data become available.This strategy should play an effective role in the development of therapies against cancer. %U https://journal.waocp.org/article_46093_f15f1a1dac2ae0435cfe0a9596639b87.pdf