%0 Journal Article %T KRAS Gene Polymorphisms and their Impact on Breast Cancer Risk in an Iranian Population %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Sanaei, Sara %A Hashemi, Mohammad %A Eskandari, Ebrahim %A Hashemi, Seyed Mehdi %A Bahari, Gholamreza %D 2017 %\ 05/01/2017 %V 18 %N 5 %P 1301-1305 %! KRAS Gene Polymorphisms and their Impact on Breast Cancer Risk in an Iranian Population %K Let-7 %K KRAS %K Polymorphism %K PCR-RFLP %K breast cancer %R 10.22034/APJCP.2017.18.5.1301 %X   Single nucleotide polymorphisms (SNPs) in the let-7 miRNA binding site within the 3’ untranslated region (3’UTR) of KRAS appear related to the risk of cancer. The present case-control study was conducted with 244 BC patients and 204 healthy women to examine whether KRAS polymorphisms (rs61764370 T/G and rs712 G/T) are associated with breast cancer (BC) risk in an Iranian population. The polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping of KRAS SNPs. Our results showed that the rs61764370 TG genotype (OR= 3.73; 95% CI =1.38-10.08; P=0.007) as well as the G allele OR= 3.56; 95% CI =1.33-9.53; P=0.008, respectively) increased the risk of BC. However, the KRAS rs712 TT vs GG+GT genotype in a recessive model was associated with a reduced risk of BC (OR= 0.56; 95% CI =0.38-0.84; P=0.006). In addition, the rs712 T allele decreased the risk of BC compared with the G allele (OR=0.75, 95%CI=0.58-0.97, P=0.031). However, we found no relationship among KRAS SNPs and clinicopathological characteristics of BC patients (P>0.05). Taken together, the present study provided evidence of relationships between KRAS polymorphisms and BC risk in a southeast Iranian population. Additional studies using larger sample sizes and diverse ethnicities are now warranted. %U https://journal.waocp.org/article_46360_d7e9f0349ff3bf90da1a1aa0852c4c18.pdf