%0 Journal Article %T Effects of Tobacco on Salivary Antioxidative and Immunologic Systems %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Arbabi-Kalati, Fateme %A Salimi, Saeede %A Nabavi, Saeede %A Rigi, Sahebdad %A Miri-Moghaddam, Masoud %D 2017 %\ 05/01/2017 %V 18 %N 5 %P 1215-1218 %! Effects of Tobacco on Salivary Antioxidative and Immunologic Systems %K Tobacco %K Saliva %K glutathione peroxide %K Superoxide dismutase %K IgA %R 10.22034/APJCP.2017.18.5.1215 %X   Background: Tobacco use is a harmful habit that causes adverse effects on oral health and plays a most important role in cancer development. Saliva is the first fluid that is exposed to tobacco and its antioxidant system plays an important role in anti-cancer potential; therefore, this study was designed to compare the antioxidant activity and immunologic system of saliva in tobacco users (smokers and smokeless tobacco users) and non-users. Materials and Methods: In this cross-sectional study, unstimulated saliva samples of 75 healthy individuals from three equal groups were investigated. Participants in group A had no periodontal disease and never smoked. Group B had no periodontal disease, never used smokeless tobacco, but had 3 years history of smoking at least 10 cigarettes daily. The twenty-five participants in group C had no periodontal disease and had 1 year history of chewing a 10-g tobacco packet daily. Activity of salivary superoxide dismutase (SOD), salivary glutathione peroxide, and salivary IgA concentration was evaluated. Data were analyzed using SPSS (version 18) and running Kruskal-Wallis test. Statistical significance was set at pResults: There were significant differences in the activities of the two enzymes and salivary IgA levels among the three groups. Activity of glutathione peroxide was higher in smokeless tobacco users. (P<0.001) while that of superoxide dismutase was higher in non-tobacco users than users (P<0.001). Salivary IgA levels were higher among smokeless tobacco users (p=0.04). Conclusion: Based on the results of the present study, the use of tobacco products decreases the antioxidative activity of the saliva and increases salivary IgA levels at the same time. %U https://journal.waocp.org/article_46639_a6aba433d8c2ffe9b6500a2571f5dbf2.pdf