%0 Journal Article %T Mean Platelet Volume and Platelet Distribution Width Are Associated with Gallbladder Cancer %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Zhang, Xin %A Niu, Ye %A Wang, Xin %A Liu, Zhi-Ping %A Liu, Tiemin %A Wang, Rui-Tao %D 2018 %\ 02/01/2018 %V 19 %N 2 %P 351-355 %! Mean Platelet Volume and Platelet Distribution Width Are Associated with Gallbladder Cancer %K gallbladder cancer %K Mean platelet volume %K Diagnosis %R 10.22034/APJCP.2018.19.2.351 %X Gallbladder cancer (GBC) represents the most common biliary tract malignancy. Activated platelets play an essentialrole in cancer development and progression. Mean platelet volume (MPV) and platelet distribution width (PDW) arecommonly used indexes of activated platelets in clinical practice. The aim of the current study was to investigate theassociation of MPV and PDW with GBC. 104 GBC patients and 109 normal control subjects were entered in thisstudy between January 2015 and December 2015. We collected all participants’ clinical and laboratory characteristicsat initial diagnosis. The odds ratios (ORs) for GBC were calculated using multivariate logistic regression analysis afteradjusting for confounding variables across MPV and PDW quartiles. MPV levels were markedly lower and PDW levelswere remarkably higher in GBC patients than control subjects. A significant correlation between PDW and lymph nodemetastasis was detected. In addition, after adjusting for other risk factors, the ORs (95% CIs) for GBC in each MPVquartile were 5.117 (1.939-13.506), 2.444 (0.917-6.516), 3.718 (1.381-10.007), and 1.000, respectively. The ORs (95%CIs) for GBC in each PDW quartile were 1.000, 2.063 (0.825-5.162), 3.070 (1.108-8.507), and 12.108 (4.243-34.553),respectively. In conclusion, decreased MPV and elevated PDW were independently associated with GBC. Our findingssuggest that MPV and PDW are available parameters for early detection of GBC. %U https://journal.waocp.org/article_57463_fd0b6c906f49cb25b8a61a2f7a7a6be3.pdf