%0 Journal Article %T Expression of Laminin in Oral Squamous Cell Carcinomas %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Yellapurkar, Shweta %A Natarajan, Srikant %A Boaz, Karen %A Manaktala, Nidhi %A Baliga, Mohan %A Shetty, Premalatha %A Prasad, Mukul %A Ravi, Mahalakshmi %D 2018 %\ 02/01/2018 %V 19 %N 2 %P 407-413 %! Expression of Laminin in Oral Squamous Cell Carcinomas %K Laminin %K Basement Membrane %K OSCC %K Prognosis %R 10.22034/APJCP.2018.19.2.407 %X Background and objectives: Laminin is a significant basement membrane (BM) glycoprotein, the expression ofwhich reflects BM integrity more precisely than do other ECM proteins. The present study aimed to evaluate lamininexpression in oral squamous cell carcinomas OSCC and to determine any associations with clinico-pathologicalparameters (surgical margin status, lymph node involvement, survival and recurrence). Methods: Laminin expression wasevaluated in 31 cases of biopsy-proven OSCC by immunohistochemical staining and its association with prognosticatorsand the Brynes grading system was determined by appropriate statistical analysis. Results: We observed a significantincrease in linear staining pattern (p<0.001) at the tumour-host interface in well-differentiated OSCC cases, in contrastto poorly differentiated lesions which exhibited intense cytoplasmic expression within tumour cells. Higher cytoplasmiclaminin expression was seen in 33.3% of cases with involved surgical margins and 69.2% of cases with lymph nodemetastasis (along with weak/absent staining of laminin around the tumour-host interface – Basement membrane aroundtumour islands). Similarly, in 60% of the cases who died and in 81.8% of cases with tumour recurrence, moderatelyintense cytoplasmic laminin expression was seen within tumour cells. On comparing variables of the Brynes gradingsystem, significant cytoplasmic expression of laminin was linked with mild inflammation (p<0.0016) and increasedmitotic activity (p<0.008). Conclusion: Based on these observations, immunohistochemical expression of lamininmight be useful to evaluate histological differentiation and aggressiveness of OSCCs. %U https://journal.waocp.org/article_57579_4b578c3ce836c8b56ac5a1a0d98919c4.pdf