%0 Journal Article %T Possible Synergistic Interactions Among Multiple HPV Genotypes in Women Suffering from Genital Neoplasia %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Hajia, Massoud %A Sohrabi, Amir %D 2018 %\ 03/01/2018 %V 19 %N 3 %P 785-789 %! Possible Synergistic Interactions Among Multiple HPV Genotypes in Women Suffering from Genital Neoplasia %K HPV %K Multi Genotypes %K Genital Infection %K Iran %R 10.22034/APJCP.2018.19.3.785 %X Objective: Persistence of HPV infection is the true cause of cervical disorders. It is reported that competitionmay exist among HPV genotypes for colonization. This survey was designed to establish the multiple HPV genotypestatus in our community and the probability of multiple HPV infections involvement. Methods: All multiple HPVinfections were selected for investigation in women suffering from genital infections referred to private laboratoriesin Tehran, Iran. A total of 160 multi HPV positive specimens from cervical scraping were identified by the HPVgenotyping methods, “INNO-LiPA and Geno Array”. Result: In present study, HPV 6 (LR), 16 (HR), 53 (pHR), 31(HR) and 11 (LR) were included in 48.8% of detected infections as the most five dominant genotypes. HPV 16 wasdetected at the highest rate with genotypes 53, 31 and 52, while HPV 53 appeared linked with HPV 16, 51 and 56in concurrent infections. It appears that HPV 16 and 53 may have significant tendencies to associate with each otherrather than with other genotypes. Analysis of the data revealed there may be some synergistic interactions with a fewparticular genotypes such as “HPV 53”. Conclusion: Multiple HPV genotypes appear more likely to be linked withdevelopment of cervical abnormalities especially in patients with genital infections. Since, there are various patternsof dominant HPV genotypes in different regions of world, more investigations of this type should be performed forcareHPV programs in individual countries. %U https://journal.waocp.org/article_57592_06019fb2e82d0a7dd272bd7d700cc996.pdf