%0 Journal Article %T Diagnostic Value of Glypican-3 for Hepatocellular Carcinomas %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A El Saadny, Sherif %A El-Demerdash, Taher %A Helmy, Amal %A Mayah, Wael Wahid %A El-Sayed Hussein, Boshra %A Hassanien, Mohammed %A Elmashad, Nehal %A Fouad, Mahmoud Ali %A Basha, Eman Ahmed %D 2018 %\ 03/01/2018 %V 19 %N 3 %P 811-817 %! Diagnostic Value of Glypican-3 for Hepatocellular Carcinomas %K Glypican-3 %K AFP %K HCC %K Diagnostic sensitivity %R 10.22034/APJCP.2018.19.3.811 %X Background: Hepatocellular carcinoma (HCC) is a common and dangerous malignancy in many parts of the world,and especially in Egypt. Early diagnosis is the most important step in successful HCC management. However mostcases are detected at late stage making effective intervention impossible. Aim: The aim of this study was to evaluatethe potential of Glypican-3 (GPC-3) to aid in diagnosis of HCC, especially in patients with low serum alpha-fetoprotein(AFP). Subjects and methods: Serum GPC-3 was assessed by flow-cytometry and serum AFP by enzyme-linkedimmunosorbent assay (ELISA) in 40 HCC patients with AFP< 400ug\l. (GI), 40 HCC patients with AFP> 400ug\l.(GII) and 20 healthy controls (GIII). Results: GPC-3 was found to be significantly elevated in HCC as compared tohealthy subjects (GI 38.2±22. 5, GII 50.2±22.6, and GIII 2.24±1.19), with sensitivities of 85% for GI and 84% for GIIand specificities of 95% for GI and 92% for GII. AFP showed respective sensitivities of 50% and 79%, and specificitiesof 80% and 90%, for HCC diagnosis. The combination of GPC-3 with AFP achieved the highest sensitivity (98.5%) andspecificity (97.8%). Conclusion: Serum GPC-3 has a better sensitivity than AFP for the diagnosis of HCC. Combinationof two markers appears warranted for greatest accuracy %U https://journal.waocp.org/article_57678_c3cb65947876e93b83288b3939fa00dc.pdf