%0 Journal Article %T Nasopharyngeal Carcinoma Protein Interaction Mapping Analysis via Proteomic Approaches %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Zamanian Azodi, Mona %A Rezaei Tavirani, Majid %A Rezaei Tavirani, Mostafa %A Vafaee, Reza %A Rostami-Nejad, Mohammad %D 2018 %\ 03/01/2018 %V 19 %N 3 %P 845-851 %! Nasopharyngeal Carcinoma Protein Interaction Mapping Analysis via Proteomic Approaches %K Nasopharyngeal carcinoma %K Protein-protein interaction network analysis %K Topological Analysis %K Gene ontology %R 10.22034/APJCP.2018.19.3.845 %X Nasopharyngeal carcinoma (NPC), although not very common in many parts of the world, is a major concern insome countries, including Iran. Molecular studies are very helpful to provide essential information regarding underlyingcarcinogenetic mechanisms. Here, considering NPC proteomic approaches, established biomarkers were designated forprotein-protein interaction network construction and analysis with corresponding plug-ins. A network of reported proteinmarkers was constructed and topological and biological process features were investigated. Centrality analysis showedthat JUN, CALM1, HSB1, and SOD1 are more important than other differentially expressed proteins in an interactingpattern. What is more, by extending the network, Tp53, PRDM10, AKT1, ALB, HSP90AA1, and EGFR achieved thehighest values for NPC network strength. It can be concluded that these proteins as well as their contributing processes,particularly in a second network, may be important for NPC onset and development. Targeting these candidate proteinsmay allow novel treatment approaches following appropriate validation. %U https://journal.waocp.org/article_57726_c800512b8978abd1e7de57d707519e95.pdf