%0 Journal Article %T Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Modares Gilani, Mitra %A Kazemi, Zohreh %A Zamani, Narges %A Shahrami, Hadis %A Ghahghaei-Nezamabadi, Akram %A Sheikham, Soureh %D 2018 %\ 04/01/2018 %V 19 %N 4 %P 897-899 %! Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases %K Endometrial cancer %K preoperative monocyte count %K tumor characteristics %K Recurrence %K tumor-associated macrophage %R 10.22034/APJCP.2018.19.4.897 %X Background: Recently preoperative hematologic parameters have attracted attention for their capacity to predicttumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in thetumor microenvironment, we evaluated the role of the preoperative monocyte count as a surrogate for TAM. Methods:We retrospectively reviewed 166 patients with histopathologically proven endometrial cancers from January 2011 toMarch 2015 and assessed any association of preoperative monocyte count with tumor characteristics and recurrence.Results: The majority of patients had tumors with the following characteristics: endometrioid histology (83.1%), lowgrade (grade I-II, 71.7%) and stage I disease (68.1%). The mean ± SD monocyte, neutrophil and platelet counts were 8.23x 109/L ± 3.56 x 109/L, 64.0 x 109/L ± 11.3 x 109/L and 261.6 x 109/L ± 74.6 x 109. Statistically significant associationswere noted with between preoperative monocyte count and tumor stage (p value=0.044), recurrence (p value<0.001) andomentum involvement (p value< 0.001) but not with tumor grade (p value=0.897), depth of myometrium involvement(p value=0.479), lymphovascular space invasion (p value=0.269) and lymph node involvement (p value=0.377).Conclusion: An elevated preoperative monocyte count is related to more aggressive tumors and a higher recurrencerate in patients with endometrial cancer. %U https://journal.waocp.org/article_58428_993ce0817080e636cae73b6b70000d8a.pdf