%0 Journal Article %T Inverse Association between Glucose‒6‒Phosphate Dehydrogenase Deficiency and Hepatocellular Carcinoma %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Dore, Maria Pina %A Vidili, Gianpaolo %A Marras, Giuseppina %A Assy, Silas %A Pes, Giovanni Mario %D 2018 %\ 04/01/2018 %V 19 %N 4 %P 1069-1073 %! Inverse Association between Glucose‒6‒Phosphate Dehydrogenase Deficiency and Hepatocellular Carcinoma %K Hepatocellular carcinoma %K glucose‒6‒phosphate dehydrogenase %K liver disease %K risk stratification %R 10.22034/APJCP.2018.19.4.1069 %X Background: Studies in experimental models and humans suggest that glucose‒6‒phosphate dehydrogenase(G6PD) deficiency, an inherited condition, may be inversely related to hepatocellular carcinoma (HCC). We testedthis hypothesis in a large cohort of Sardinian patients. Methods: A case-control study was performed using datafrom 11,143 records of patients who underwent upper endoscopy between 2002 and 2017. Gender, age, G6PD statusand information regarding the presence of HCC, were recorded. Cases (HCC positive) and controls (HCC negative)were compared for the presence of G6PD deficiency adjusting for major HCC risk factors using logistic regression.Results: Overall, 114 HCC cases and 11,029 controls were identified. G6PD deficiency was detected in 11.5% ofstudy participants, and was associated with a reduced risk of HCC [odds ratio (OR); 0.451; 95% confidence interval(CI), 0.207−0.982] after adjusting for all covariates. Factors significantly associated with HCC were cirrhosis (OR,23.30; 95% CI, 11.48−47.25), diabetes (OR, 2.396; 95% CI, 1.449−3.963), among infection hepatitis HBV with anOR of 2.326, age ≥65 years (OR, 1.941; 95% CI, 1.234−2.581) and male gender (OR, 1.611; 95% CI, 1.006−3.081).Conclusions: Our study revealed a significant inverse association between G6PD deficiency and risk of HCC. Thesefindings need to be confirmed in further studies. %U https://journal.waocp.org/article_59739_762ac36e69f8cae5f2440751974517ea.pdf