%0 Journal Article %T Evaluating the Oncogenic and Tumor Suppressor Role of XPO5 in Different Tissue Tumor Types %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Khan, Munazza %A Khan, Zafaruddin %A Uddin, Yaser %A Mustafa, Sadaf %A Shaukat, Irfan %A Pan, Jianbo %A Höti, Naseruddin %D 2018 %\ 04/01/2018 %V 19 %N 4 %P 1119-1125 %! Evaluating the Oncogenic and Tumor Suppressor Role of XPO5 in Different Tissue Tumor Types %K miRNA %K TMA %K XPO5 %K Tumors %K IHC %R 10.22034/APJCP.2018.19.4.1119 %X The miRNAs nuclear export protein XPO5 has been previously studied in several individual malignancies. In ourrecent study we have demonstrated that excess levels of XPO5 enhanced the proliferation of prostate cancer cells.Similarly, there are studies to support the inhibitory role of XPO5 in cancers. In order to evaluate discrepancies in theexpression levels of XPO5 in differential tumor types, we quantified the expression of XPO5 using gene expressionRNA-seq data for several tumor types which were independently confirmed by immunohistochemistry in multipleorgans cancer tissue microarray (TMAs) experiment. We found that while some tumors (Breast, Bladder, Lymph-node,Lung, Esophagus and Ovary) showed higher differences between normal and malignant tumors in XPO5 expression,there were tissues (Kidney and Brain) that have a significantly lower XPO5 expression in malignant tumors. We furtherstudies these observations of overexpression and down-regulation of XPO5 in breast and kidney cancer cell lines andfound that XPO5 might have a dual role in promoting or inhibiting tumor growth in different cancer tissue types. %U https://journal.waocp.org/article_59852_bdf658105e5dfdae593897e0fee3c954.pdf