%0 Journal Article %T Patient Reported Weight Loss Predicts Recurrence Rate in Renal Cell Cancer Cases after Nephrectomy %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Tiwari, Priya %A Kumar, Lalit %A Thulkar, Sanjay %A Singh, Geetika %A Malik, Prabhat %A Seth, Amlesh %D 2018 %\ 04/01/2018 %V 19 %N 4 %P 891-895 %! Patient Reported Weight Loss Predicts Recurrence Rate in Renal Cell Cancer Cases after Nephrectomy %K Renal cell cancer %K weight loss %K Recurrence-free survival %K Fuhrman grade %R 10.22034/APJCP.2018.19.4.891 %X Background: Recurrence of renal cell cancer (RCC) affects approximately one-third of patients after curativenephrectomy. However, studies from the Indian subcontinent have been scarce. We here ddetermine relapse ratesand patterns in an Indian cohort. Methods: This study included all patients with RCC who underwent nephrectomyfrom 2004 to 2013 at our centre. Recurrence-free survival (RFS) was calculated from the date of surgery to date ofrecurrence or death. The Cox regression model was applied to identify significant prognostic factors. Results: Overalla total of 292 patients were included. Median age was 50 years (range 19-84 years), with a male:female ratio of 3:1.Radical and partial nephrectomy were performed for 276 (94.5%) and 16 (5.5%) patients, respectively. Clear cell wasmost common histological subtype (71.2%) and T1, T2, T3 and T4 stages accounted for 89 (30.5%), 86 (29.5%), 105(36%) and 12 (4.1%) patients, respectively. One hundred and thirty-six patients (46.6%) demonstrated recurrence.Eighty-six (63.2%) relapsed at distant sites, 14 (10.3%) and at locoregional sites whereas 36(26.5%) had both distantand locoregional recurrence. Median time to recurrence was 18 months. Approximately 17.7% of cases had diseasereappearance after five years. Factors predicting shorter RFS on multivariate analysis were patient reported weightloss (p=0.004), Fuhrman grade 3 or 4 (p<0.0001), presence of necrosis (p<0.0001) and higher tumour stage (p=0.005).Conclusion: Compared to previous studies, our patients had higher rates of recurrence in general and locoregionalrecurrence in particular. However, except for weight loss, other predictive factors remain similar. Finding weight lossas the marker of recurrence emphasises the importance of the simple task of history taking. %U https://journal.waocp.org/article_60324_6db55708b19e0af9dadc1f62bdd9465e.pdf