%0 Journal Article %T Clinical Response to CHOP vs. R-CHOP in Adult Patients with Diffuse Large B-Cell Lymphomas %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Tariq, Ayesha %A Aziz, Muhammad Tahir %A Mehmood, Yasir %A Asghar, Shehroz Ali %A Khurshid, Azhar %D 2018 %\ 05/01/2018 %V 19 %N 5 %P 1181-1184 %! Clinical Response to CHOP vs. R-CHOP in Adult Patients with Diffuse Large B-Cell Lymphomas %K Keywords: CHOP %K RCHOP %K clinical response evaluation %K DLBCL %R 10.22034/APJCP.2018.19.5.1181 %X Purpose: The purpose of this study was to address the question of “superiority of R-CHOP versus CHOP”, withaddition of Rituximab to CHOP, regarding survival of patients suffering from DLBCL. Patients and methods: A cohortretrospective design was used to conduct this study in a tertiary care hospital. A total of 100 patients (50 in each group)were randomly selected. The primary and secondary end points were EFS, OS, PFS and DFS. Kaplan Meier survivalcurve analysis (log rank, Breslow and Tarone ware tests) was employed to compare probability of survival for the twogroups (CHOP/ R-CHOP). Results: The mean primary and secondary clinical indicators were estimated for each group(EFS, 1.7; 3.09 with a p value P=0.02), (OS, 0.60; 0.43 with a p value P=0.40), (PFS, 1.73; 3.57 with a p value P=0.002), (DFS, 0.02; 0.48 with a p value of P=0.00). Conclusion:The results for differences in clinical response were statistically significant in favor of the R-CHOP group. %U https://journal.waocp.org/article_60678_cbc6144ea30ca946dac773031ce96323.pdf