%0 Journal Article %T Selective Cytotoxicity of α-Santonin from the Persian Gulf Sponge Dysidea Avara on Pediatric ALL B-lymphocytes via Mitochondrial Targeting %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Aghvami, Marjan %A Keshavarz, Arghavan %A Nazemi, Melika %A Zarei, Mohammad Hadi %A Pourahmad, Jalal %D 2018 %\ 08/01/2018 %V 19 %N 8 %P 2149-2154 %! Selective Cytotoxicity of α-Santonin from the Persian Gulf Sponge Dysidea Avara on Pediatric ALL B-lymphocytes via Mitochondrial Targeting %K B-ALL lymphocyte %K Dysideaavara %K mitochondria %K Apoptosis %R 10.22034/APJCP.2018.19.8.2149 %X Background: Acute lymphoblastic leukemia (ALL) is one of the most dominant malignancies among children,characterized by production of immature and dysfunctional blasts which are resistant to cytotoxic chemotherapeuticagents. Therefore, research protocols are currently focusing on discovery of novel anti-cancer agents to enhance survivalrates and decrease unwanted side effects. Approximately two-thirds of the planet is covered by oceans with a massiverange of marine organisms of interest to scientists in pharmaceutical fields. Methods: Among marine resources, spongesare known to have beneficial effects in the treatment of numerous malignancies. One fraction of crude extracts containingα-Santonin was made from the Persian Gulf marine sponge, Dysidea avara, and investigated for anticancer effects.Results: Treatment of ALL B-lymphocytes with the Dysidea avara extract caused augmentation in ROS generation,decline in mitochondrial membrane potential, mitochondrial swelling, release of cytochrome c from mitochondriaand activation of caspase-3 only in mitochondria isolated from B-ALL lymphocytes. Conclusion: In brief, our resultssuggest that Dysidea avara extracts may selectively induce apoptosis in malignant pediatric lymphocytes. %U https://journal.waocp.org/article_66270_1cb0fafd60af2ae2010ddb03bbf6d5f1.pdf